231 research outputs found
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The landscape of psoriasis provision in the UK.
Psoriasis remains one of the commonest conditions seen in dermatological practice, and its treatment is one of the greatest cost burdens for the UK National Health Service. Treatment of psoriasis is complex, with numerous overlapping lines and therapies used in combination. This complexity reflects the underlying pathophysiology of the disease as well as the heterogeneous population that it affects. National Institute for Health and Care Excellence (NICE) guidance for the treatment of psoriasis has been available since 2013, and has been the subject of three national audits conducted by the British Association of Dermatologists. This report synthesizes the results of the most recent of those exercises and places it in the context of the NICE guidance and previous audits. It clearly shows the significant burden of disease, issues with provision of services and long waiting times and the marked shift in therapies towards targeted biologic therapies
Cortical beta oscillations are associated with motor performance following visuomotor learning
© 2019 The Authors People vary in their capacity to learn and retain new motor skills. Although the relationship between neuronal oscillations in the beta frequency range (15–30 Hz) and motor behaviour is well established, the electrophysiological mechanisms underlying individual differences in motor learning are incompletely understood. Here, we investigated the degree to which measures of resting and movement-related beta power from sensorimotor cortex account for inter-individual differences in motor learning behaviour in the young and elderly. Twenty young (18–30 years) and twenty elderly (62–77 years) healthy adults were trained on a novel wrist flexion/extension tracking task and subsequently retested at two different time points (45–60 min and 24 h after initial training). Scalp EEG was recorded during a separate simple motor task before each training and retest session. Although short-term motor learning was comparable between young and elderly individuals, there was considerable variability within groups with subsequent analysis aiming to find the predictors of this variability. As expected, performance during the training phase was the best predictor of performance at later time points. However, regression analysis revealed that movement-related beta activity significantly explained additional variance in individual performance levels 45–60 min, but not 24 h after initial training. In the context of disease, these findings suggest that measurements of beta-band activity may offer novel targets for therapeutic interventions designed to promote rehabilitative outcomes
Universal Critical Behavior of Aperiodic Ferromagnetic Models
We investigate the effects of geometric fluctuations, associated with
aperiodic exchange interactions, on the critical behavior of -state
ferromagnetic Potts models on generalized diamond hierarchical lattices. For
layered exchange interactions according to some two-letter substitutional
sequences, and irrelevant geometric fluctuations, the exact recursion relations
in parameter space display a non-trivial diagonal fixed point that governs the
universal critical behavior. For relevant fluctuations, this fixed point
becomes fully unstable, and we show the apperance of a two-cycle which is
associated with a novel critical behavior. We use scaling arguments to
calculate the critical exponent of the specific heat, which turns out
to be different from the value for the uniform case. We check the scaling
predictions by a direct numerical analysis of the singularity of the
thermodynamic free-energy. The agreement between scaling and direct
calculations is excellent for stronger singularities (large values of ). The
critical exponents do not depend on the strengths of the exchange interactions.Comment: 4 pages, 1 figure (included), RevTeX, submitted to Phys. Rev. E as a
Rapid Communicatio
The Critical Behaviour of the Spin-3/2 Blume-Capel Model in Two Dimensions
The phase diagram of the spin-3/2 Blume-Capel model in two dimensions is
explored by conventional finite-size scaling, conformal invariance and Monte
Carlo simulations. The model in its -continuum Hamiltonian version is
also considered and compared with others spin-3/2 quantum chains. Our results
indicate that differently from the standard spin-1 Blume-Capel model there is
no multicritical point along the order-disorder transition line. This is in
qualitative agreement with mean field prediction but in disagreement with
previous approximate renormalization group calculations. We also presented new
results for the spin-1 Blume-Capel model.Comment: latex 18 pages, 4 figure
Short-Range Ising Spin Glass: Multifractal Properties
The multifractal properties of the Edwards-Anderson order parameter of the
short-range Ising spin glass model on d=3 diamond hierarchical lattices is
studied via an exact recursion procedure. The profiles of the local order
parameter are calculated and analysed within a range of temperatures close to
the critical point with four symmetric distributions of the coupling constants
(Gaussian, Bimodal, Uniform and Exponential). Unlike the pure case, the
multifractal analysis of these profiles reveals that a large spectrum of the
-H\"older exponent is required to describe the singularities of the
measure defined by the normalized local order parameter, at and below the
critical point. Minor changes in these spectra are observed for distinct
initial distributions of coupling constants, suggesting an universal spectra
behavior. For temperatures slightly above T_{c}, a dramatic change in the
function is found, signalizing the transition.Comment: 8 pages, LaTex, PostScript-figures included but also available upon
request. To be published in Physical Review E (01/March 97
Universality and scaling study of the critical behavior of the two-dimensional Blume-Capel model in short-time dynamics
In this paper we study the short-time behavior of the Blume-Capel model at
the tricritical point as well as along the second order critical line. Dynamic
and static exponents are estimated by exploring scaling relations for the
magnetization and its moments at early stage of the dynamic evolution. Our
estimates for the dynamic exponents, at the tricritical point, are and .Comment: 12 pages, 9 figure
Field-induced Ordering in Critical Antiferromagnets
Transfer-matrix scaling methods have been used to study critical properties
of field-induced phase transitions of two distinct two-dimensional
antiferromagnets with discrete-symmetry order parameters: triangular-lattice
Ising systems (TIAF) and the square-lattice three-state Potts model (SPAF-3).
Our main findings are summarised as follows. For TIAF, we have shown that the
critical line leaves the zero-temperature, zero -field fixed point at a finite
angle. Our best estimate of the slope at the origin is . For SPAF-3 we provided evidence that the zero-field correlation
length diverges as , with , through analysis of the critical curve at plus crossover
arguments. For SPAF-3 we have also ascertained that the conformal anomaly and
decay-of-correlations exponent behave as: (a) H=0: ; (b) .Comment: RevTex, 7 pages, 4 eps figures, to be published in Phys. Rev.
Lattice gauge theory with baryons at strong coupling
We study the effective Hamiltonian for strong-coupling lattice QCD in the
case of non-zero baryon density. In leading order the effective Hamiltonian is
a generalized antiferromagnet. For naive fermions, the symmetry is U(4N_f) and
the spins belong to a representation that depends on the local baryon number.
Next-nearest-neighbor (nnn) terms in the Hamiltonian break the symmetry to
U(N_f) x U(N_f). We transform the quantum problem to a Euclidean sigma model
which we analyze in a 1/N_c expansion. In the vacuum sector we recover
spontaneous breaking of chiral symmetry for the nearest-neighbor and nnn
theories. For non-zero baryon density we study the nearest-neighbor theory
only, and show that the pattern of spontaneous symmetry breaking depends on the
baryon density.Comment: 31 pages, 5 EPS figures. Corrected Eq. (6.1
Spanning forests and the q-state Potts model in the limit q \to 0
We study the q-state Potts model with nearest-neighbor coupling v=e^{\beta
J}-1 in the limit q,v \to 0 with the ratio w = v/q held fixed. Combinatorially,
this limit gives rise to the generating polynomial of spanning forests;
physically, it provides information about the Potts-model phase diagram in the
neighborhood of (q,v) = (0,0). We have studied this model on the square and
triangular lattices, using a transfer-matrix approach at both real and complex
values of w. For both lattices, we have computed the symbolic transfer matrices
for cylindrical strips of widths 2 \le L \le 10, as well as the limiting curves
of partition-function zeros in the complex w-plane. For real w, we find two
distinct phases separated by a transition point w=w_0, where w_0 = -1/4 (resp.
w_0 = -0.1753 \pm 0.0002) for the square (resp. triangular) lattice. For w >
w_0 we find a non-critical disordered phase, while for w < w_0 our results are
compatible with a massless Berker-Kadanoff phase with conformal charge c = -2
and leading thermal scaling dimension x_{T,1} = 2 (marginal operator). At w =
w_0 we find a "first-order critical point": the first derivative of the free
energy is discontinuous at w_0, while the correlation length diverges as w
\downarrow w_0 (and is infinite at w = w_0). The critical behavior at w = w_0
seems to be the same for both lattices and it differs from that of the
Berker-Kadanoff phase: our results suggest that the conformal charge is c = -1,
the leading thermal scaling dimension is x_{T,1} = 0, and the critical
exponents are \nu = 1/d = 1/2 and \alpha = 1.Comment: 131 pages (LaTeX2e). Includes tex file, three sty files, and 65
Postscript figures. Also included are Mathematica files forests_sq_2-9P.m and
forests_tri_2-9P.m. Final journal versio
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