358 research outputs found
Temporal Dynamics of Hypothesis Generation: The Influences of Data Serial Order, Data Consistency, and Elicitation Timing
The pre-decisional process of hypothesis generation is a ubiquitous cognitive faculty that we continually employ in an effort to understand our environment and thereby support appropriate judgments and decisions. Although we are beginning to understand the fundamental processes underlying hypothesis generation, little is known about how various temporal dynamics, inherent in real world generation tasks, influence the retrieval of hypotheses from long-term memory. This paper presents two experiments investigating three data acquisition dynamics in a simulated medical diagnosis task. The results indicate that the mere serial order of data, data consistency (with previously generated hypotheses), and mode of responding influence the hypothesis generation process. An extension of the HyGene computational model endowed with dynamic data acquisition processes is forwarded and explored to provide an account of the present data
Observing supermassive black holes in virtual reality
We present a 360∘ (i.e., 4π steradian) general-relativistic ray-tracing and radiative transfer calculations of accreting supermassive black holes. We perform state-of-the-art three-dimensional general-relativistic magnetohydrodynamical simulations using the BHAC code, subsequently post-processing this data with the radiative transfer code RAPTOR. All relativistic and general-relativistic effects, such as Doppler boosting and gravitational redshift, as well as geometrical effects due to the local gravitational field and the observer’s changing position and state of motion, are therefore calculated self-consistently. Synthetic images at four astronomically-relevant observing frequencies are generated from the perspective of an observer with a full 360∘ view inside the accretion flow, who is advected with the flow as it evolves. As an example we calculated images based on recent best-fit models of observations of Sagittarius A*. These images are combined to generate a complete 360∘ Virtual Reality movie of the surrounding environment of the black hole and its event horizon. Our approach also enables the calculation of the local luminosity received at a given fluid element in the accretion flow, providing important applications in, e.g., radiation feedback calculations onto black hole accretion flows. In addition to scientific applications, the 360∘ Virtual Reality movies we present also represent a new medium through which to interactively communicate black hole physics to a wider audience, serving as a powerful educational tool
The Extended X-ray Halo of the Crab-like SNR G21.5-0.9
Recent XMM-Newton observations reveal an extended (150") low-surface
brightness X-ray halo in the supernova remnant G21.5-0.9. The near circular
symmetry, the lack of any limb brightening and the non-thermal spectral form,
all favour an interpretation of this outer halo as an extension of the central
synchrotron nebula rather than as a shell formed by the supernova blast wave
and ejecta. The X-ray spectrum of the nebula exhibits a marked spectral
softening with radius, with the power-law spectral index varying from Gamma =
1.63 +/- 0.04 in the core to Gamma = 2.45 +/- 0.06 at the edge of the halo.
Similar spectral trends are seen in other Crab-like remnants and reflect the
impact of the synchrotron radiation losses on very high energy electrons as
they diffuse out from the inner nebula. A preliminary timing analysis provides
no evidence for any pulsed X-ray emission from the core of G21.5-0.9.Comment: 6 pages. Accepted for publication in the Astronomy and Astrophysics
Special Issue on 1st science with XMM-Newto
The Local Bubble, Local Fluff, and Heliosphere
The properties of the Local Bubble, Local Fluff complex of nearby
interstellar clouds, and the heliosphere are mutually constrained by data and
theory. Observations and models of the diffuse radiation field, interstellar
ionization, pick-up ion and anomalous cosmic-ray populations, and interstellar
dust link the physics of these regions. The differences between the
one-asymmetric-superbubble and two-superbubble views of the Local Bubble are
discussed.Comment: 10 pages, 2 figure
The Relation Between the Surface Brightness and the Diameter for Galactic Supernova Remnants
In this work, we have constructed a relation between the surface brightness
() and diameter (D) of Galactic C- and S-type supernova remnants
(SNRs). In order to calibrate the -D dependence, we have carefully
examined some intrinsic (e.g. explosion energy) and extrinsic (e.g. density of
the ambient medium) properties of the remnants and, taking into account also
the distance values given in the literature, we have adopted distances for some
of the SNRs which have relatively more reliable distance values. These
calibrator SNRs are all C- and S-type SNRs, i.e. F-type SNRs (and S-type SNR
Cas A which has an exceptionally high surface brightness) are excluded. The
Sigma-D relation has 2 slopes with a turning point at D=36.5 pc: (at 1
GHz)=8.4 D
WmHzster (for
WmHzster and D36.5 pc) and (at 1
GHz)=2.7 10 D
WmHzster (for
WmHzster and D36.5 pc). We discussed the theoretical
basis for the -D dependence and particularly the reasons for the change
in slope of the relation were stated. Added to this, we have shown the
dependence between the radio luminosity and the diameter which seems to have a
slope close to zero up to about D=36.5 pc. We have also adopted distance and
diameter values for all of the observed Galactic SNRs by examining all the
available distance values presented in the literature together with the
distances found from our -D relation.Comment: 45 pages, 2 figures, accepted for publication in Astronomical and
Astrophysical Transaction
A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 Serotype
We have shown previously that replacement of the spike (S) gene of the apathogenic IBV strain Beau-R with that from the pathogenic strain of the same serotype, M41, resulted in an apathogenic virus, BeauR-M41(S), that conferred protection against challenge with M41 [1]. We have constructed a recombinant IBV, BeauR-4/91(S), with the genetic backbone of Beau-R but expressing the spike protein of the pathogenic IBV strain 4/91(UK), which belongs to a different serogroup as Beaudette or M41. Similar to our previous findings with BeauR-M41(S), clinical signs observations showed that the S gene of the pathogenic 4/91 virus did not confer pathogenicity to the rIBV BeauR-4/91(S). Furthermore, protection studies showed there was homologous protection; BeauR-4/91(S) conferred protection against challenge with wild type 4/91 virus as shown by the absence of clinical signs, IBV RNA assessed by qRT-PCR and the fact that no virus was isolated from tracheas removed from birds primarily infected with BeauR-4/91(S) and challenged with IBV 4/91(UK). A degree of heterologous protection against M41 challenge was observed, albeit at a lower level
The spread of marine anoxia on the northern Tethys margin during the Paleocene-Eocene Thermal Maximum
Records of the paleoenvironmental changes that occurred during the Paleocene-Eocene Thermal Maximum (PETM) are preserved in sedimentary rocks along the margins of the former Tethys Ocean and Peri-Tethys. This paper presents new geochemical data that constrain paleoproductivity, sediment delivery, and seawater redox conditions, from three sites that were located in the Peri-Tethys region. Trace and major element, iron speciation, and biomarker data indicate that water column anoxia was established during episodes when inputs of land-derived higher plant organic carbon and highly weathered detrital clays and silts became relatively higher. Anoxic conditions are likely to have been initially caused by two primary processes: (i) oxygen consumption by high rates of marine productivity, initially stimulated by the rapid delivery of terrestrially derived organic matter and nutrients, and (ii) phosphorus regeneration from seafloor sediments. The role of the latter process requires further investigation before its influence on the spread of deoxygenated seawater during the PETM can be properly discerned. Other oxygen-forcing processes, such as temperature/salinity-driven water column stratification and/or methane oxidation, are considered to have been relatively less important in the study region. Organic carbon enrichments occur only during the initial stages of the PETM as defined by the negative carbon isotope excursions at each site. The lack of observed terminal stage organic carbon enrichment does not support a link between PETM climate recovery and the sequestration of excess atmospheric CO2 as organic carbon in this region; such a feedback may, however, have been important in the early stages of the PETM
Recall termination in free recall
Although much is known about the dynamics of memory search in the free recall task, relatively little is known about the factors related to recall termination. Reanalyzing individual trial data from 14 prior studies (1,079 participants in 28,015 trials) and defining termination as occurring when a final response is followed by a long nonresponse interval, we observed that termination probability increased throughout the recall period and that retrieval was more likely to terminate following an error than following a correct response. Among errors, termination probability was higher following prior-list intrusions and repetitions than following extralist intrusions. To verify that this pattern of results can be seen in a single study, we report a new experiment in which 80 participants contributed recall data from a total of 9,122 trials. This experiment replicated the pattern observed in the aggregate analysis of the prior studies
Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis
Objective: Interleukin-17A (IL-17A) and tumor necrosis factor (TNF) contribute to the pathogenesis of psoriatic arthritis (PsA). However, their functional relationship in PsA synovitis has not been fully elucidated. Additionally, although CD8+ T cells in PsA have been recognized via flow cytometry as a source of IL-17A production, it is not clear whether CD8+ T cells secrete IL-17A under more physiologically relevant conditions in the context from PsA synovitis. This study was undertaken to clarify the roles of IL-17A and TNF in the synovial fluid (SF) from patients with PsA and investigate the impact of CD8+ T cells on IL-17A production. Methods: IL-17A+ T cells were identified by flow cytometry in SF samples from 20 patients with active PsA, blood samples from 22 treatment-naive patients with PsA, and blood samples from 22 healthy donors. IL-17A+ T cells were sorted from 12 PsA SF samples and stimulated using anti-CD3/anti-CD28 or phorbol myristate acetate (PMA) and ionomycin ex vivo, alone (n = 3) or together with autologous monocytes (n = 3) or PsA fibroblast-like synoviocytes (FLS) (n = 5–6). To evaluate the differential allogeneic effects of neutralizing IL-17A and TNF, SF CD4+ T cells and PsA FLS cocultures were also used (n = 5–6). Results: Flow cytometry analyses of SF samples from patients with PsA showed IL-17A positivity for CD4+ and CD8+ T cells (IL-17A, median 0.71% [interquartile range 0.35–1.50%] in CD4+ cells; median 0.44% [interquartile range 0.17–1.86%] in CD8+ T cells). However, only CD4+ T cells secreted IL-17A after ant
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