Deterministic reaction models with power-law forces

We study a one-dimensional particles system, in the overdamped limit, where nearest particles attract with a force inversely proportional to a power of their distance and coalesce upon encounter. The detailed shape of the distribution function for the gap between neighbouring particles serves to discriminate between different laws of attraction. We develop an exact Fokker-Planck approach for the infinite hierarchy of distribution functions for multiple adjacent gaps and solve it exactly, at the mean-field level, where correlations are ignored. The crucial role of correlations and their effect on the gap distribution function is explored both numerically and analytically. Finally, we analyse a random input of particles, which results in a stationary state where the effect of correlations is largely diminished

A Field Range Bound for General Single-Field Inflation

We explore the consequences of a detection of primordial tensor fluctuations for general single-field models of inflation. Using the effective theory of inflation, we propose a generalization of the Lyth bound. Our bound applies to all single-field models with two-derivative kinetic terms for the scalar fluctuations and is always stronger than the corresponding bound for slow-roll models. This shows that non-trivial dynamics can't evade the Lyth bound. We also present a weaker, but completely universal bound that holds whenever the Null Energy Condition (NEC) is satisfied at horizon crossing.Comment: 16 page

Scale-Invariance and the Strong Coupling Problem

The effective theory of adiabatic fluctuations around arbitrary Friedmann-Robertson-Walker backgrounds - both expanding and contracting - allows for more than one way to obtain scale-invariant two-point correlations. However, as we show in this paper, it is challenging to produce scale-invariant fluctuations that are weakly coupled over the range of wavelengths accessible to cosmological observations. In particular, requiring the background to be a dynamical attractor, the curvature fluctuations are scale-invariant and weakly coupled for at least 10 e-folds only if the background is close to de Sitter space. In this case, the time-translation invariance of the background guarantees time-independent n-point functions. For non-attractor solutions, any predictions depend on assumptions about the evolution of the background even when the perturbations are outside of the horizon. For the simplest such scenario we identify the regions of the parameter space that avoid both classical and quantum mechanical strong coupling problems. Finally, we present extensions of our results to backgrounds in which higher-derivative terms play a significant role.Comment: 17 pages + appendices, 3 figures; v2: typos fixe

Sterile neutrino production via active-sterile oscillations: the quantum Zeno effect

We study several aspects of the kinetic approach to sterile neutrino production via active-sterile mixing. We obtain the neutrino propagator in the medium including self-energy corrections up to $\mathcal{O}(G^2_F)$, from which we extract the dispersion relations and damping rates of the propagating modes. The dispersion relations are the usual ones in terms of the index of refraction in the medium, and the damping rates are $\Gamma_1(k) = \Gamma_{aa}(k) \cos^2\theta_m(k); \Gamma_2(k) = \Gamma_{aa}(k) \sin^2\theta_m(k)$ where $\Gamma_{aa}(k)\propto G^2_F k T^4$ is the active neutrino scattering rate and $\theta_m(k)$ is the mixing angle in the medium. We provide a generalization of the transition probability in the \emph{medium from expectation values in the density matrix}: $P_{a\to s}(t) = \frac{\sin^22\theta_m}{4}[e^{-\Gamma_1t} + e^{-\Gamma_2 t}-2e^{-{1/2}(\Gamma_1+\Gamma_2)t} \cos\big(\Delta E t\big)]$ and study the conditions for its quantum Zeno suppression directly in real time. We find the general conditions for quantum Zeno suppression, which for $m_s\sim \textrm{keV}$ sterile neutrinos with $\sin2\theta \lesssim 10^{-3}$ \emph{may only be} fulfilled near an MSW resonance. We discuss the implications for sterile neutrino production and argue that in the early Universe the wide separation of relaxation scales far away from MSW resonances suggests the breakdown of the current kinetic approach.Comment: version to appear in JHE

Supersymmetric probes on the conifold

We study the supersymmetric embeddings of different D-brane probes in the AdS_5 x T^{1,1} geometry. The main tool employed is kappa symmetry and the cases studied include D3-, D5- and D7-branes. We find a family of three-cycles of the T^{1,1} space over which a D3-brane can be wrapped supersymmetrically and we determine the field content of the corresponding gauge theory duals. Supersymmetric configurations of D5-branes wrapping a two-cycle and of spacetime filling D7-branes are also found. The configurations in which the entire T^{1,1} space is wrapped by a D5-brane (baryon vertex) and a D7-brane are also studied. Some other embeddings which break supersymmetry but are nevertheless stable are also determined.Comment: 44 pages, LaTeX; v2: typos corrected, references added, discussion of D5-brane embeddings improve

An Active Learning Approach for Rapid Characterization of Endothelial Cells in Human Tumors

Currently, no available pathological or molecular measures of tumor angiogenesis predict response to antiangiogenic therapies used in clinical practice. Recognizing that tumor endothelial cells (EC) and EC activation and survival signaling are the direct targets of these therapies, we sought to develop an automated platform for quantifying activity of critical signaling pathways and other biological events in EC of patient tumors by histopathology. Computer image analysis of EC in highly heterogeneous human tumors by a statistical classifier trained using examples selected by human experts performed poorly due to subjectivity and selection bias. We hypothesized that the analysis can be optimized by a more active process to aid experts in identifying informative training examples. To test this hypothesis, we incorporated a novel active learning (AL) algorithm into FARSIGHT image analysis software that aids the expert by seeking out informative examples for the operator to label. The resulting FARSIGHT-AL system identified EC with specificity and sensitivity consistently greater than 0.9 and outperformed traditional supervised classification algorithms. The system modeled individual operator preferences and generated reproducible results. Using the results of EC classification, we also quantified proliferation (Ki67) and activity in important signal transduction pathways (MAP kinase, STAT3) in immunostained human clear cell renal cell carcinoma and other tumors. FARSIGHT-AL enables characterization of EC in conventionally preserved human tumors in a more automated process suitable for testing and validating in clinical trials. The results of our study support a unique opportunity for quantifying angiogenesis in a manner that can now be tested for its ability to identify novel predictive and response biomarkers

Present and Future CP Measurements

We review theoretical and experimental results on CP violation summarizing the discussions in the working group on CP violation at the UK phenomenology workshop 2000 in Durham.Comment: 104 pages, Latex, to appear in Journal of Physics

Warped Tachyonic Inflation in Type IIB Flux Compactifications and the Open-String Completeness Conjecture

We consider a cosmological scenario within the KKLT framework for moduli stabilization in string theory. The universal open string tachyon of decaying non-BPS D-brane configurations is proposed to drive eternal topological inflation. Flux-induced `warping' can provide the small slow-roll parameters needed for successful inflation. Constraints on the parameter space leading to sufficient number of e-folds, exit from inflation, density perturbations and stabilization of the Kahler modulus are investigated. The conditions are difficult to satisfy in Klebanov-Strassler throats but can be satisfied in T^3 fibrations and other generic Calabi-Yau manifolds. This requires large volume and magnetic fluxes on the D-brane. The end of inflation may or may not lead to cosmic strings depending on the original non-BPS configuration. A careful investigation of initial conditions leading to a phenomenologically viable model for inflation is carried out. The initial conditions are chosen on the basis of Sen's open string completeness conjecture. We find time symmetrical bounce solutions without initial singularities for k=1 FRW models which are correlated with an inflationary period. Singular big-bang/big-crunch solutions also exist but do not lead to inflation. There is an intriguing correlation between having an inflationary universe in 4 dimensions and 6 compact dimensions or a big-crunch singularity and decompactification.Comment: 43 pages, 9 figures. v3: Typos correcte