Pion Photoproduction Amplitude Relations in the 1/N_c Expansion

We derive expressions for pion photoproduction amplitudes in the 1/N_c expansion of QCD, and obtain linear relations directly from this expansion that relate electromagnetic multipole amplitudes at all energies. The leading-order relations in 1/N_c compare favorably with available data, while the next-to-leading order relations seem to provide only a small improvement. However, when resonance parameters are compared directly, the agreement at O(1/N_c) or O(1/N_c^2) is impressive.Comment: 19 pages, ReVTeX, 50 eps files combine into 5 compound figure

Pion-Nucleon Scattering Relations at Next-to-Leading Order in 1/N_c

We obtain relations between partial-wave amplitudes for pi-N-->pi-N and pi-N-->pi-Delta directly from large N_c QCD. While linear relations among certain amplitudes holding at leading order (LO) in 1/N_c were derived in the context of chiral soliton models two decades ago, the present work employs a fully model-independent framework based on consistency with the large N_c expansion. At LO we reproduce the soliton model results; however, this method allows for systematic corrections. At next-to-leading order (NLO), most relations require additional unknown functions beyond those appearing at leading order (LO) and thus have little additional predictive power. However, three NLO relations for the pi-N-->pi-Delta reaction are independent of unknown functions and make predictions accurate at this order. The amplitudes relevant to two of these relations were previously extracted from experiment. These relations describe experiment dramatically better than their LO counterparts.Comment: 8 pages, 2 figures; references adde

Analysis of a distributed fiber-optic temperature sensor using single-photon detectors

We demonstrate a high-accuracy distributed fiber-optic temperature sensor using superconducting nanowire single-photon detectors and single-photon counting techniques. Our demonstration uses inexpensive single-mode fiber at standard telecommunications wavelengths as the sensing fiber, which enables extremely low-loss experiments and compatibility with existing fiber networks. We show that the uncertainty of the temperature measurement decreases with longer integration periods, but is ultimately limited by the calibration uncertainty. Temperature uncertainty on the order of 3 K is possible with spatial resolution of the order of 1 cm and integration period as small as 60 seconds. Also, we show that the measurement is subject to systematic uncertainties, such as polarization fading, which can be reduced with a polarization diversity receiver

Nucleon-Nucleon Scattering under Spin-Isospin Reversal in Large-N_c QCD

The spin-flavor structure of certain nucleon-nucleon scattering observables derived from the large N_c limit of QCD in the kinematical regime where time-dependent mean-field theory is valid is discussed. In previous work, this regime was taken to be where the external momentum was of order N_c which precluded the study of differential cross sections in elastic scattering. Here it is shown that the regime extends down to order N_c^{1/2} which includes the higher end of the elastic regime. The prediction is that in the large N_c limit, observables describable via mean-field theory are unchanged when the spin and isospin of either nucleon are both flipped. This prediction is tested for proton-proton and neutron-proton elastic scattering data and found to fail badly. We argue that this failure can be traced to a lack of a clear separation of scales between momentum of order N_c^{1/2} and N_c^1 when N_c is as small as three. The situation is compounded by an anomalously low particle production threshold due to approximate chiral symmetry.Comment: 5 pages, 1 figur

Excited Baryon Decay Widths in Large N_c QCD

We study excited baryon decay widths in large N_c QCD. It was suggested previously that some spin-flavor mixed-symmetric baryon states have strong couplings of O(N_c^{-1/2}) to nucleons [implying narrow widths of O(1/N_c)], as opposed to the generic expectation based on Witten's counting rules of an O(N_c^0) coupling. The calculation obtaining these narrow widths was performed in the context of a simple quark-shell model. This paper addresses the question of whether the existence of such narrow states is a general property of large N_c QCD. We show that a general large N_c QCD analysis does not predict such narrow states; rather they are a consequence of the extreme simplicity of the quark model.Comment: 9 page

Rationale for and design of the "POSTA" study: Evaluation of neurocognitive outcomes after immediate adenotonsillectomy compared to watchful waiting in preschool children

Background: IQ deficits are linked to even mild obstructive sleep apnoea (OSA) in children. Although OSA is commonly first diagnosed in the pre-school age group, a randomised trial is still needed to assess IQ outcomes after adenotonsillectomy in the pre-school age-group. This randomised control trial (RCT) will primarily determine whether adenotonsillectomy improves IQ compared to no adenotonsillectomy after 12 months, in preschool (3–5 year-old) children with mild to moderate OSA. Methods: This protocol is for an ongoing multi-centred RCT with a recruitment target of 210 subjects (105 in each arm). Children age 3–5 years with symptoms of OSA, are recruited through doctor referral, at the point of referral to the Ear Nose and Throat (ENT) services. Screening is initially with a questionnaire (Paediatric Sleep Questionnaire, PSQ) for symptoms of obstructive sleep apnoea (OSA). Where questionnaires are positive (suggestive of OSA) and ENT surgeons recommend them for adenotonsillectomy, they are invited to participate in POSTA. Baseline testing includes neurocognitive testing (IQ and psychometric evaluation with the neuropsychologist blinded to randomisation) and overnight polysomnography (PSG). Where the Obstructive Apnoea-Hypopnea Index (OAHI) from the PSG is <10/h per hour, consent for randomisation is sought; children with severe OSA (OAHI ≥ 10/h) are sent for immediate treatment and excluded from the study. After consent is obtained, participants are randomised to early surgery (within 2 months) or to surgery after a usual wait time of 12 months. Follow-up studies include repeat neurocognitive testing and PSG at 12 (with the waiting list group studied before their surgery) and 24 months after randomisation. Analysis will be by intention to treat. The primary outcome is IQ at 12 months’ follow-up. Discussion: If IQ deficits associated with OSA are reversible 12 months after adenotonsillectomy compared to controls, future clinical practice advise would be to undertake early surgery in young children with OSA. The study could provide data on whether a window of opportunity exists for reversing IQ deficits linked to OSA in the pre-school age-group. Trial registration: Australian and New Zealand Clinical Trials Registration Number ACTRN12611000021976.Karen A. Waters, Jasneek Chawla, Margaret-Anne Harris, Carolyn Dakin, Helen Heussler, Robert Black, Alan Cheng, Hannah Burns, John D. Kennedy and Kurt Lushingto

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review

Background: Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or variability often goes unreported. While full reporting of original trial data is the ideal, we sought to identify methods for handling unreported mean or variability summary statistics in meta-analysis. Methods: We undertook two systematic literature reviews to identify methodological approaches used to deal with missing mean or variability summary statistics. Five electronic databases were searched, in addition to the Cochrane Colloquium abstract books and the Cochrane Statistics Methods Group mailing list archive. We also conducted cited reference searching and emailed topic experts to identify recent methodological developments. Details recorded included the description of the method, the information required to implement the method, any underlying assumptions and whether the method could be readily applied in standard statistical software. We provided a summary description of the methods identified, illustrating selected methods in example meta-analysis scenarios. Results: For missing standard deviations (SDs), following screening of 503 articles, fifteen methods were identified in addition to those reported in a previous review. These included Bayesian hierarchical modelling at the meta-analysis level; summary statistic level imputation based on observed SD values from other trials in the meta-analysis; a practical approximation based on the range; and algebraic estimation of the SD based on other summary statistics. Following screening of 1124 articles for methods estimating the mean, one approximate Bayesian computation approach and three papers based on alternative summary statistics were identified. Illustrative meta-analyses showed that when replacing a missing SD the approximation using the range minimised loss of precision and generally performed better than omitting trials. When estimating missing means, a formula using the median, lower quartile and upper quartile performed best in preserving the precision of the meta-analysis findings, although in some scenarios, omitting trials gave superior results. Conclusions: Methods based on summary statistics (minimum, maximum, lower quartile, upper quartile, median) reported in the literature facilitate more comprehensive inclusion of randomised controlled trials with missing mean or variability summary statistics within meta-analyses

Branching on multi-aggregated variables

open5siopenGamrath, Gerald; Melchiori, Anna; Berthold, Timo; Gleixner, Ambros M.; Salvagnin, DomenicoGamrath, Gerald; Melchiori, Anna; Berthold, Timo; Gleixner, Ambros M.; Salvagnin, Domenic

The Relative Importance of Clinical, Economic, Patient Values and Feasibility Criteria in Cancer Drug Reimbursement in Canada:A Revealed Preferences Analysis of Recommendations of the Pan-Canadian Oncology Drug Review 2011–2017

Background: Most Canadian provinces and territories rely on the pan-Canadian Oncology Drug Review (pCODR) to provide recommendations regarding public reimbursement of cancer drugs. The pCODR review process considers four dimensions of value—clinical benefit, economic evaluation, patient-based values and adoption feasibility—but they do not define weights for individual decision criteria or an acceptable threshold for any of the criteria. Given this implicit review process, it is of interest to understand which factors appear to carry the most weight in pCODR recommendations using a revealed preferences approach. Methods: Using publicly available decision summaries (n = 91) describing submissions and resulting recommendations 2011–2017, we extracted ten attributes that characterized each submission. Using logistic regression, we identified statistically significant attributes and estimated their relative impact in final recommendations. Results: Clinical aspects appear to carry the greatest weight in the decision to reject or not reject, along with aspects of patient value (treatments with no alternatives were less likely to be rejected). Cost effectiveness does not appear to play a role in the initial decision to reject or not reject but is critical in full versus conditional approvals. There is evidence of a maximum acceptable threshold of around $Can140,000 per quality-adjusted life-year (QALY) gained. Conclusion: A set of factors driving pCODR recommendations is identifiable, supporting the consistency of the review process. However, the implicit nature of the review process and the difficulty of extracting and interpreting some of the attribute levels used in the analysis suggests that the process may still lack full transparency