The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis.

Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption. This study determined the associations between adipokines and selected measures of the renin-angiotensinogen-aldosterone system (RAAS). The sample consisted of 1970 men and women from the Multi-Ethnic Study of Atherosclerosis who were free of clinical cardiovascular disease at baseline and had blood assayed for adiponectin, leptin, plasma renin activity (PRA) and aldosterone. The mean age was 64.7 years and 50% were female. The mean (s.d.) PRA and aldosterone were 1.45 (0.56) ng ml(-1) and 150.1 (130.5) pg ml(-1), respectively. After multivariable adjustment, a 1-s.d. increment of leptin was associated with a 0.55 ng ml(-1) higher PRA and 8.4 pg ml(-1) higher aldosterone (P<0.01 for both). Although adiponectin was not significantly associated with PRA levels, the same increment in this adipokine was associated with lower aldosterone levels (-5.5 pg ml(-1), P=0.01). Notably, the associations between aldosterone and both leptin and adiponectin were not materially changed with additional adjustment for PRA. Exclusion of those taking antihypertensive medications modestly attenuated the associations. The associations between leptin and both PRA and aldosterone were not different by gender but were significantly stronger among non-Hispanic Whites and Chinese Americans than African and Hispanic Americans (P<0.01). The findings suggest that both adiponectin and leptin may be relevant to blood pressure regulation via the RAAS, in that the associations appear to be robust to antihypertension medication use and that the associations are likely different by ethnicity

The Episcopal Church in Florida During the Civil War

As the Civil War approached, the Episcopal Church in Flor- ida found herself for the first time since the opening of the territory in a position of stability. She had weathered the hardships and uncertainties of the territorial period; her older parishes had become self-supporting congregations, and were embarking on vigorous parochial and educational projects; and a new group of lively missions was springing up in towns like Fernandina, Ocala, and Palatka, and in agricultural villages like Waukeena and Milton. The Diocese of Florida, which had been bishopless for thirteen years after its organization in 1838, had enjoyed the episcopal ministrations of its own diocesan since 1851, and as a sign of financial stability, the diocesan enjoyed a stipend which was paid with a degree of regularity that would have seemed strange to him five years before

The Blockade and Fall of Apalachicola, 1861-1862

President Lincoln proclaimed the blockade of all Confederate ports on April 19, 1861. In order to make the blockade effective, the United States Navy was split into two squadrons: the Atlantic Squadron which was to guard the entire Atlantic coast as far south as Cape Florida; and the Gulf Squadron which was responsible for the vast Gulf coast, an area which extended from Cape Florida to the Mexican border. Early in 1862 the Gulf Squadron was divided again into a West Gulf Squadron and an East Gulf Squadron. The area guarded by the East Gulf Squadron extended from Cape Canaveral on the Atlantic to St. Andrew’s Bay on the Gulf. It was this command, with its headquarters in Key West, to which the approaches of Apalachicola were assigned

A classical particle with spin realized by reduction of a nonlinear nonholonomic constraint

In this paper we describe the motion of a nonlinear nonholonomically constrained system which after reduction realizes a nonrelativistic classical particle with spin

Three-layer flows in the shallow water limit

We formulate and discuss the shallow water limit dynamics of the layered flow with three layers of immiscible fluids of different densities bounded above and below by horizontal walls. We obtain a resulting system of four equations, which may be nonlocal in the non‐Boussinesq case. We provide a systematic way to pass to the Boussinesq limit, and then study those equations, which are first‐order PDEs of mixed type, more carefully. We show that in a symmetric case the solutions remain on an invariant surface and using simple waves we illustrate that this is not the case for nonsymmetric cases. Reduced models consisting of systems of two equations are also proposed and compared to the full system

Oak forest carbon and water simulations:Model intercomparisons and evaluations against independent data

Models represent our primary method for integration of small-scale, process-level phenomena into a comprehensive description of forest-stand or ecosystem function. They also represent a key method for testing hypotheses about the response of forest ecosystems to multiple changing environmental conditions. This paper describes the evaluation of 13 stand-level models varying in their spatial, mechanistic, and temporal complexity for their ability to capture intra- and interannual components of the water and carbon cycle for an upland, oak-dominated forest of eastern Tennessee. Comparisons between model simulations and observations were conducted for hourly, daily, and annual time steps. Data for the comparisons were obtained from a wide range of methods including: eddy covariance, sapflow, chamber-based soil respiration, biometric estimates of stand-level net primary production and growth, and soil water content by time or frequency domain reflectometry. Response surfaces of carbon and water flux as a function of environmental drivers, and a variety of goodness-of-fit statistics (bias, absolute bias, and model efficiency) were used to judge model performance. A single model did not consistently perform the best at all time steps or for all variables considered. Intermodel comparisons showed good agreement for water cycle fluxes, but considerable disagreement among models for predicted carbon fluxes. The mean of all model outputs, however, was nearly always the best fit to the observations. Not surprisingly, models missing key forest components or processes, such as roots or modeled soil water content, were unable to provide accurate predictions of ecosystem responses to short-term drought phenomenon. Nevertheless, an inability to correctly capture short-term physiological processes under drought was not necessarily an indicator of poor annual water and carbon budget simulations. This is possible because droughts in the subject ecosystem were of short duration and therefore had a small cumulative impact. Models using hourly time steps and detailed mechanistic processes, and having a realistic spatial representation of the forest ecosystem provided the best predictions of observed data. Predictive ability of all models deteriorated under drought conditions, suggesting that further work is needed to evaluate and improve ecosystem model performance under unusual conditions, such as drought, that are a common focus of environmental change discussions

Planning the Future of U.S. Particle Physics (Snowmass 2013): Chapter 4: Cosmic Frontier

These reports present the results of the 2013 Community Summer Study of the APS Division of Particles and Fields ("Snowmass 2013") on the future program of particle physics in the U.S. Chapter 4, on the Cosmic Frontier, discusses the program of research relevant to cosmology and the early universe. This area includes the study of dark matter and the search for its particle nature, the study of dark energy and inflation, and cosmic probes of fundamental symmetries.Comment: 61 page