Analytical evaluation of the X-ray scattering contribution to imaging degradation in grazing-incidence X-ray telescopes

The focusing performance of X-ray optics (conveniently expressed in terms of HEW, Half Energy Width) strongly depend on both mirrors deformations and photon scattering caused by the microroughness of reflecting surfaces. In particular, the contribution of X-ray Scattering (XRS) to the HEW of the optic is usually an increasing function H(E) of the photon energy E. Therefore, in future hard X-ray imaging telescopes of the future (SIMBOL-X, NeXT, Constellation-X, XEUS), the X-ray scattering could be the dominant problem since they will operate also in the hard X-ray band (i.e. beyond 10 keV). [...] Several methods were proposed in the past years to estimate the scattering contribution to the HEW, dealing with the surface microroughness expressed in terms of its Power Spectral Density (PSD), on the basis of the well-established theory of X-ray scattering from rough surfaces. We faced that problem on the basis on the same theory, but we tried a new approach: the direct, analytical translation of a given surface roughness PSD into a H(E) trend, and - vice versa - the direct translation of a H(E) requirement into a surface PSD. This PSD represents the maximum tolerable microroughness level in order to meet the H(E) requirement in the energy band of a given X-ray telescope. We have thereby found a new, analytical and widely applicable formalism to compute the XRS contribution to the HEW from the surface PSD, provided that the PSD had been measured in a wide range of spatial frequencies. The inverse problem was also solved, allowing the immediate evaluation of the mirror surface PSD from a measured function H(E). The same formalism allows establishing the maximum allowed PSD of the mirror in order to fulfill a given H(E) requirement. [...]Comment: 10 pages, 6 figures, published in Astronomy & Astrophysics, sect. "Astronomical Instrumentation". In this version, a typo in two equations has been corrected. After the correction, the other results, formulae and conclusions in the paper remain unchange

Approaches to canine health surveillance

Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of these measures. The key attributes for optimal data collection systems that support canine disease surveillance are representativeness of the general population, validity of disorder data and sustainability. Limitations in these areas present as selection bias, misclassification bias and discontinuation of the system respectively. Canine health data sources are reviewed to identify their strengths and weaknesses for supporting effective canine health surveillance. Insurance data benefit from large and well-defined denominator populations but are limited by selection bias relating to the clinical events claimed and animals covered. Veterinary referral clinical data offer good reliability for diagnoses but are limited by referral bias for the disorders and animals included. Primary-care practice data have the advantage of excellent representation of the general dog population and recording at the point of care by veterinary professionals but may encounter misclassification problems and technical difficulties related to management and analysis of large datasets. Questionnaire surveys offer speed and low cost but may suffer from low response rates, poor data validation, recall bias and ill-defined denominator population information. Canine health scheme data benefit from well-characterised disorder and animal data but reflect selection bias during the voluntary submissions process. Formal UK passive surveillance systems are limited by chronic under-reporting and selection bias. It is concluded that active collection systems using secondary health data provide the optimal resource for canine health surveillance

Longevity and mortality of owned dogs in England

Improved understanding of longevity represents a significant welfare opportunity for the domestic dog, given its unparalleled morphological diversity. Epidemiological research using electronic patient records (EPRs) collected from primary veterinary practices overcomes many inherent limitations of referral clinic, owner questionnaire and pet insurance data. Clinical health data from 102,609 owned dogs attending first opinion veterinary practices (n = 86) in central and southeast England were analysed, focusing on 5095 confirmed deaths. Of deceased dogs with information available, 3961 (77.9%) were purebred, 2386 (47.0%) were female, 2528 (49.8%) were neutered and 1105 (21.7%) were insured. The overall median longevity was 12.0 years (IQR 8.9–14.2). The longest-lived breeds were the Miniature poodle, Bearded collie, Border collie and Miniature dachshund, while the shortest-lived were the Dogue de Bordeaux and Great Dane. The most frequently attributed causes of death were neoplastic, musculoskeletal and neurological disorders. The results of multivariable modelling indicated that longevity in crossbred dogs exceeded purebred dogs by 1.2 years (95% confidence interval 0.9–1.4; P < 0.001) and that increasing bodyweight was negatively correlated with longevity. The current findings highlight major breed differences for longevity and support the concept of hybrid vigour in dogs

Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England

Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from primary-care practice are emerging as a useful source of epidemiological data in companion animals. This study used large volumes of health data from UK primary-care practices participating in the VetCompass animal health surveillance project to evaluate in detail the disorders diagnosed in a random selection of over 50% of dogs recorded as Cavalier King Charles Spaniels (CKCSs). Confirmation of breed using available microchip and Kennel Club (KC) registration data was attempted

Demography and health of Pugs under primary veterinary care in England

BACKGROUND: The Pug is an ancient dog breed and was the fifth most commonly registered UK pedigree breed in 2014. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory and dermatological problems. The VetCompass Programme collates de-identified clinical data from primary-care veterinary practices in the UK for epidemiological research. Using VetCompass clinical data, this study aimed to characterise the demography and common disorders of the general population of Pugs under veterinary care in England. RESULTS: Pugs comprised 2709 (1.03 %) of 264,260 study dogs under veterinary care from September 1(st), 2009 to 30(th) April, 2015. Annual proportional birth rates showed that Pugs rose from less than 1 % of annual birth cohorts before 2008 to comprise 2.8 % of the 2013 annual birth cohort. The most common colours of Pugs were fawn (63.1 %), black (27.7 %), apricot (7.6 %) and silver (2.1 %). Of the 1009 pugs under veterinary care in the study during 2013, 688 (68.19 %) had at least one disorder recorded. The most prevalent disorders recorded overall were overweight/obesity (number of events: 133, prevalence: 13.18 %, 95 % CI: 11.12–15.43), corneal disorder (88, 8.72 %, 95 % CI: 7.05–10.63) and otitis externa (76, 7.53 %, 95 % CI: 5.98–9.34). The most prevalent disorder groups were ophthalmological (n = 164, prevalence: 16.25 %, 95 % CI: 14.03–18.68), dermatological (157, 15.60 %, 95 % CI: 13.38–17.95) and aural (152, 15.06 %, 95 % CI: 12.91–17.42). The most prevalent body locations affected were the head-and-neck (n = 439, prevalence = 43.51 %, 95 % CI: 40.42–46.63) and abdomen (195, 19.33 %, 95 % CI: 16.93–21.90). The most prevalent organ systems affected were the integument (321, 31.81 %, 95 % CI: 28.15–35.72) and digestive (257, 25.47 %, 95 % CI: 22.54–28.65). The most prevalent pathophysiologic processes recorded were inflammation (386, 38.26 %, 95 % CI: 34.39–42.27) and congenital/developmental (153, 15.16 %, 95 % CI: 12.61–18.13). CONCLUSIONS: Ownership of Pugs in England is rising steeply. Overweight/obesity, corneal disorder and otitis externa are the most common disorders in Pugs. Identification of health priorities based on VetComapss data can support evidence–based reforms to improve health and welfare within the breed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40575-016-0035-z) contains supplementary material, which is available to authorized users

An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK

This study aimed to estimate the prevalence of canine diabetes mellitus (DM) in primary-care clinics in England, to identify risk factors associated with DM and to describe the survival of affected dogs. Cases of DM were identified within the electronic patient records of 89 small-animal practices. A nested case–control study identified risk factors for the diagnosis of DM using logistic regression models. Cox proportional hazards models were used to analyse variables associated with survival. Four-hundred and thirty-nine canine DM cases were identified, giving an apparent prevalence of 0.34% (95% CI 0.31% to 0.37%). Neutered males were at an increased risk of diabetes compared with entire males, whereas neutering was not associated with DM in females. When compared with crossbred dogs, Yorkshire terriers had increased odds, whereas German shepherd dogs and golden retrievers had lower odds of DM. Being classified as overweight and having a diagnosis of pancreatitis, hyperadrenocorticism or a urinary tract infection were positively associated with DM. Older dogs and those diagnosed with pancreatitis had a higher hazard of death, whereas insured and neutered dogs had a lower hazard. This study provides an objective assessment of canine DM using primary-care veterinary practice data and is a valuable benchmark against which future epidemiological trends in DM can be assessed and improvements in the management of DM in primary-care practice can be judged

Measuring the Galaxy Cluster Bulk Flow from WMAP data

We have looked for bulk motions of galaxy clusters in the WMAP~7 year data. We isolate the kinetic Sunyaev-Zeldovich (SZ) signal by filtering the WMAP Q, V and W band maps with multi-frequency matched filters, that utilize the spatial properties of the kinetic SZ signal to optimize detection. We try two filters: a filter that has no spectral dependence, and a filter that utilizes the spectral properties of the kinetic and thermal SZ signals to remove the thermal SZ bias. We measure the monopole and dipole spherical harmonic coefficients of the kinetic SZ signal, as well as the $\ell=2-5$ modes, at the locations of 736 ROSAT observed galaxy clusters. We find no significant power in the kinetic SZ signal at these multipoles with either filter, consistent with the $\Lambda$CDM prediction. Our limits are a factor of ~ 3 more sensitive than the claimed bulk flow detection of~\citet{2009ApJ...691.1479K}. Using simulations we estimate that in maps filtered by our matched filter with no spectral dependence there is a thermal SZ dipole that would be mistakenly measured as a bulk motion of $\sim \! 2000-4000$ km/s. For the WMAP data the signal to noise ratio obtained with the unbiased filter is almost an order of magnitude lower.Comment: 31 pages, 25 figures. Added an appendix with more discussion of previous results. Some discussion added to answer the referee's comment

Discovery of narrow X-ray absorption features from the dipping low-mass X-ray binary X 1624-490 with XMM-Newton

We report the discovery of narrow X-ray absorption features from the dipping low-mass X-ray binary X 1624-490 during an XMM-Newton observation in 2001 February. The features are identified with the K alpha absorption lines of Fe xxv and Fe xxvi and have energies of 6.72 +/- 0.03 keV and 7.00 +/- 0.02 keV and equivalent widths (EWs) of -7.5 +1.7 -6.3 eV and -16.6 +1.9 -5.9 eV, respectively. The EWs show no obvious dependence on orbital phase, except during a dip, and correspond to a column of greater than 10^17.3 Fe atom /cm2. In addition, faint absorption features tentatively identified with Ni xxvii K alpha and Fe xxvi K beta may be present. A broad emission feature at 6.58 +0.07 -0.04 keV with an EW of 78 +19 -6 eV is also evident. This is probably the 6.4 keV feature reported by earlier missions since fitting a single Gaussian to the entire Fe-K region gives an energy of 6.39 +0.03 -0.04 keV. A deep absorption feature is present during the dip with an energy consistent with Fe xxv K alpha. This is the second dipping LMXRB source from which narrow Fe absorption features have been observed. Until recently the only X-ray binaries known to exhibit narrow X-ray absorption lines were two superluminal jet sources and it had been suggested that these features are related to the jet formation mechanism. It now appears likely that ionized absorption features may be common characteristics of accreting systems with accretion disks.Comment: 6 pages. To appear in A&