Manipulation of ultracold atomic mixtures using microwave techniques

We used microwave radiation to evaporatively cool a mixture of of 133Cs and 87Rb atoms in a magnetic trap. A mixture composed of an equal number (around 10^4) of Rb and Cs atoms in their doubly polarized states at ultracold temperatures was prepared. We also used microwaves to selectively evaporate atoms in different Zeeman states.Comment: 9 pages, 6 figure

Analysis of ring laser gyroscopes including laser dynamics

Inertial sensors stimulate very large interest, not only for their application but also for fundamental physics tests. Ring laser gyros, which measure angular rotation rate, are certainly among the most sensitive inertial sensors, with excellent dynamic range and bandwidth. Large area ring laser gyros are routinely able to measure fractions of prad/s, with high duty cycle and bandwidth, providing fast, direct and local measurement of relevant geodetic and geophysical signals. Improvements of a factor $10-100$ would open the windows for general relativity tests, as the GINGER project, an Earth based experiment aiming at the Lense-Thirring test at $1\%$ level. However, it is well known that the dynamics of the laser induces non-linearities, and those effects are more evident in small scale instruments. Sensitivity and accuracy improvements are always worthwhile, and in general there is demand for high sensitivity environmental study and development of inertial platforms, where small scale transportable instruments should be used. We discuss a novel technique to analyse the data, aiming at studying and removing those non-linearity. The analysis is applied to the two ring laser prototypes GP2 and GINGERINO, and angular rotation rate evaluated with the new and standard methods are compared. The improvement is evident, it shows that the back-scatter problem of the ring laser gyros is negligible with a proper analysis of the data, improving the performances of large scale ring laser gyros, but also indicating that small scale instruments with sensitivity of nrad/s are feasible.Comment: 9 pages and 7 figure

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural product whose molecular mode of action was unknown. The new ternatin variants are cytotoxic toward cancer cells, with up to 500-fold greater potency than ternatin itself. Using a ternatin photo-affinity probe, we identify the translation elongation factor-1A ternary complex (eEF1A·GTP·aminoacyl-tRNA) as a specific target and demonstrate competitive binding by the unrelated natural products, didemnin and cytotrienin. Mutations in domain III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating the adjacent hydrophobic surface as a functional hot spot for eEF1A modulation. We conclude that the eukaryotic elongation factor-1A and its ternary complex with GTP and aminoacyl-tRNA are common targets for the evolution of cytotoxic natural products

Sistema Metas© na Embrapa Gado de Leite: apoio à gestão da informação geradora de conhecimento: documento orientador.

Introdução; Objetivos deste documento; A necessidade da organização do conhecimento como resultado e como processo; O apoio à gestão da informação e do conhecimento na Embrapa Gado de Leite: histórico; O Sistema de registros e acompanhamento da produção da Embrapa Gado de Leite: Sistema Metas©; Qualificação comprobatória de produções; Como o Sistema Metas© corrobora a Compliance na Embrapa Gado de Leite; Registro de produções no Sistema Metas©; Registro de artigos em periódicos indexados; Registro de artigos (publicados em anais); Registro de capítulo em livro técnico/científico; Registro de teses e dissertações; Registro de notas técnicas (short communication); Registro de resumos em anais de congresso Registro de artigos de divulgação na mídia; Registro de Boletim de Pesquisa e Desenvolvimento; Registro de Circular Técnica, Documentos, Comunicado Técnico/Recomendações; Registro de Organização/Edição de livros; Registro de Sistema de Produção; Registro de ações de Transferência de Tecnologia e Promoção da Imagem; Geração de relatórios de produção no sistema Metas©; Relatório simultâneo de todas as produções do sistema; Considerações finais sobre o Sistema Metas©.bitstream/item/210647/1/Embrapa-doc-243-final.pd

Deep-well ultrafast manipulation of a SQUID flux qubit

Superconducting devices based on the Josephson effect are effectively used for the implementation of qubits and quantum gates. The manipulation of superconducting qubits is generally performed by using microwave pulses with frequencies from 5 to 15 GHz, obtaining a typical operating clock from 100MHz to 1GHz. A manipulation based on simple pulses in the absence of microwaves is also possible. In our system a magnetic flux pulse modifies the potential of a double SQUID qubit from a symmetric double well to a single deep well condition. By using this scheme with a Nb/AlOx/Nb system we obtained coherent oscillations with sub-nanosecond period (tunable from 50ps to 200ps), very fast with respect to other manipulating procedures, and with a coherence time up to 10ns, of the order of what obtained with similar devices and technologies but using microwave manipulation. We introduce the ultrafast manipulation presenting experimental results, new issues related to this approach (such as the use of a feedback procedure for cancelling the effect of "slow" fluctuations), and open perspectives, such as the possible use of RSFQ logic for the qubit control.Comment: 9 pages, 7 figure

Preliminary thermal-hydraulic design and predicted performance of the Clinch River Breeder Reactor core

The preliminary thermofluids design of the core assemblies of the Clinch River Breeder Reactor Plant (CRBRP) is presented along with the predicted performance for various plant operating conditions. The selected radial blanket assemblies shuffling scheme and the new approach adopted for fuel and blanket assemblies orificing is discussed. Relevant thermofluids parameters (assembly flow rate and mixed mean outlet temperature, fuel rod temperatures, fission gas plenum pressure, etc.) are presented. Highlights of a detailed uncertainties study performed are summarized. This preliminary analysis has shown that the CRBRP core behavior is compatible with design limits and requirements; future developments for a final analysis are outlined. (auth

Evaluating case studies of community-oriented integrated care.

This paper summarises a ten-year conversation within London Journal of Primary Care about the nature of community-oriented integrated care (COIC) and how to develop and evaluate it. COIC means integration of efforts for combined disease-treatment and health-enhancement at local, community level. COIC is similar to the World Health Organisation concept of a Community-Based Coordinating Hub - both require a local geographic area where different organisations align their activities for whole system integration and develop local communities for health. COIC is a necessary part of an integrated system for health and care because it enables multiple insights into 'wicked problems', and multiple services to integrate their activities for people with complex conditions, at the same time helping everyone to collaborate for the health of the local population. The conversation concludes seven aspects of COIC that warrant further attention