C4 NULL ALLELES IN A SWEDISH POPULATION

The distribution of C4 null alleles (C4Q0) was studied in a Swedish population comprising 410 male individuals from Stockholm County and Uppsala City. The prevalances of homozygous C4A*Q0 and C4B*Q0 determined by analysing the gene products in serum were 5.0 and 5.6%, respectively, in the Stockholm population and 4.0% each in the Uppsala population. These values are higher than those previously reported from other Caucasian populations. The finding reflects a different genetic composition of the Swedish population and may have relevance to the disease spectrum in this population as compared to other Caucasian populations

Association of HLA-A and Non-Classical HLA Class I Alleles.

The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H. Thus, the principal objective of this study was to describe the main allelic associations between HLA-A and HLA-H, -G, -F and -E. Therefore, HLA-A, -E, -G, -H and -F coding polymorphisms, as well as HLA-G UnTranslated Region haplotypes (referred to as HLA-G UTRs), were explored in 191 voluntary blood donors. Allelic frequencies, Global Linkage Disequilibrium (GLD), Linkage Disequilibrium (LD) for specific pairs of alleles and two-loci haplotype frequencies were estimated. We showed that HLA-A, HLA-H, HLA-F, HLA-G and HLA-G UTRs were all in highly significant pairwise GLD, in contrast to HLA-E. Moreover, HLA-A displayed restricted associations with HLA-G UTR and HLA-H. We also confirmed several associations that were previously found to have a negative impact on transplantation outcome. In summary, our results suggest complex functional and clinical implications of the HLA-A genetic region

Measurement of the X(3872) production cross section via decays to J/ψπ + π − in pp collisions at s=7 \sqrt{s}=7 TeV

The production of the X(3872) is studied in pp collisions at sqrt(s) = 7 TeV, using decays to J/psi pi pi, where the J/psi decays to two muons. The data were recorded by the CMS experiment and correspond to an integrated luminosity of 4.8 inverse femtobarns. The measurements are performed in a kinematic range in which the X(3872) candidates have a transverse momentum 10 < pt < 50 GeV and rapidity abs(y) < 1.2. The ratio of the X(3872) and psi(2S) cross sections times their branching fractions into J/psi pi pi is measured as a function of pt. In addition, the fraction of X(3872) originating from B decays is determined. From these measurements the prompt X(3872) differential cross section times branching fraction as a function of pt is extracted. The pi pi mass spectrum of the J/psi pi pi system in the X(3872) decays is also investigated