Insulin and serine metabolism as sex-specific hallmarks of Alzheimer's disease in the human hippocampus

Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics approach, we investigate alterations in the molecular composition of postmortem hippocampus samples of healthy persons and individuals with AD. Profound differences are apparent between control and AD male and female cohorts in terms of up- and downregulated metabolic pathways. A decrease in the insulin response is evident in AD when comparing the female with the male group. The serine metabolism (linked to the glycolytic pathway and generating the N-methyl-D-aspartate [NMDA] receptor coagonist D-serine) is also significantly modulated: the D-Ser/total serine ratio represents a way to counteract age-related cognitive decline in healthy men and during AD onset in women. These results show how AD changes and, in certain respects, almost reverses sex-specific proteomic and metabolomic profiles, highlighting how different pathophysiological mechanisms are active in men and women

USE OF POLYETHYLENE-GLYCOL IN THE SYNTHESIS OF ALKYL FLUORIDES FROM ALKYL SULFONATES

Due borse di studio post doc per ricerche nel campo dell’Umanesimo e del Rinascimento per l'anno 2017-2018 Istituto Nazionale di Studi sul Rinascimento - Regione Toscana - Fondazione Cassa Risparmio di Firenze L’Istituto Nazionale di Studi sul Rinascimento bandisce due borse di studio post doc, con il contributo della Regione Toscana e della Fondazione Cassa di Risparmio di Firenze, per l’anno 2017-2018 per ricerche nel campo dell’Umanesimo e del Rinascimento. Esse sono bandite per studiosi ..