4,471 research outputs found
Thin film dielectric microstrip kinetic inductance detectors
Microwave Kinetic Inductance Detectors, or MKIDs, are a type of low
temperature detector that exhibit intrinsic frequency domain multiplexing at
microwave frequencies. We present the first theory and measurements on a MKID
based on a microstrip transmission line resonator. A complete characterization
of the dielectric loss and noise properties of these resonators is performed,
and agrees well with the derived theory. A competitive noise equivalent power
of 5 W Hz at 1 Hz has been demonstrated. The
resonators exhibit the highest quality factors known in a microstrip resonator
with a deposited thin film dielectric.Comment: 10 pages, 4 figures, APL accepte
Reduction of Ion Heating During Magnetic Reconnection by Large-Scale Effective Potentials
The physical processes that control the partition of released magnetic energy
between electrons and ions during reconnection is explored through
particle-in-cell simulations and analytical techniques. We demonstrate that the
development of a large-scale parallel electric field and its associated
potential controls the relative heating of electrons and ions. The potential
develops to restrain heated exhaust electrons and enhances their heating by
confining electrons in the region where magnetic energy is released.
Simultaneously the potential slows ions entering the exhaust below the
Alfv\'enic speed expected from the traditional counterstreaming picture of ion
heating. Unexpectedly, the magnitude of the potential and therefore the
relative partition of energy between electrons and ions is not a constant but
rather depends on the upstream parameters and specifically the upstream
electron normalized temperature (electron beta). These findings suggest that
the fraction of magnetic energy converted into the total thermal energy may be
independent of upstream parameters
Validation of national genetic evaluations for maternal beef cattle traits using Irish field data
peer-reviewedGenetic evaluations provide information to aid in breeding decisions that increase long-term performance of animals and herds. However, to date no study has been undertaken to investigate the accuracy of the Irish maternal genetic evaluations in beef cattle. The objective, therefore, of this study was to quantify the relationship between phenotypic performance and measures of genetic merit for predominantly maternal-related traits in Irish beef cattle. The association between animal EBV for calving interval, age at first calving, and both direct and maternal weaning weight with the respective phenotypic performance was quantified using a fixed effects model; the expectation for the regression coefficient of phenotypic performance on EBV was one. The association between genetic merit for cow survival, perinatal mortality, calving assistance, and calving dystocia with the log of the odds of the respective trait was quantified using logistic regression. The association analyses were conducted using field data on up to 38,619 records from 5,236 herds. Age at first calving increased linearly by 0.32 ± 0.15 (P = 0.03) days per day increase in EBV for age at first calving. Calving interval increased by, on average, 0.58 ± 0.16 (P = 0.002) days per day increase in EBV for calving interval although the association differed by parity with a greater association in pluriparae. Weaning weight increased linearly by 1.74 ± 0.09 and 0.84 ± 0.16 kg (P < 0.001) per kilogram increase in EBV for direct and maternal weaning weight, respectively. The log of the odds of a cow surviving to next lactation increased linearly by 0.16 ± 0.03 (P < 0.001) per unit increase in EBV for cow survival. The log of the odds of an assisted calving or dystocia both increased linearly by 0.21 ± 0.01 and 0.24 ± 0.01, respectively, per unit increase in EBV for direct calving difficulty (P < 0.001). The log of the odds of a dead calf at birth increased linearly by 0.93 ± 0.13 (P < 0.001) per unit increase in EBV for calf mortality. Results from this study show that selection of breeding animals for favorable maternal genetic attributes will result in favorable improvements in performance and profitability
Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH.
OBJECTIVES: The aim of this study was to gain an insight into the molecular mechanisms of the evolution of rifampicin resistance in response to controlled changes in the environment. METHODS: We determined the proportion of rpoB mutants in the chemostat culture and characterized the sequence of mutations found in the rifampicin resistance-determining region of rpoB in a steady-state chemostat at pH 7.0 and 6.2. RESULTS: The overall proportion of rpoB mutants of strain H37Rv remained constant for 37 days at pH 7.0, ranging between 3.6 x 10(-8) and 8.9 x 10(-8); however, the spectrum of mutations varied. The most commonly detected mutation, serine to leucine mutation at codon 531 (S531L), increased from 40% to 89%, while other mutations (S531W, H526Y, H526D, H526R, S522L and D516V) decreased over the 37 day sampling period. Changing the pH from 7.0 to 6.2 did not significantly alter the overall proportion of mutants, but resulted in a decrease in the percentage of strains harbouring S531L (from 89% to 50%) accompanied by an increase in the range of different mutations from 4 to 12. CONCLUSIONS: The data confirm that the fitness of strains with the S531L mutation is greater than that of strains containing other mutations. We also conclude that at low pH the environment is permissive for a wider spectrum of mutations, which may provide opportunities for a successful mutant to survive
Osteoblastoma of the thyroid cartilage treated with voice preserving laryngeal framework resection
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99105/1/lary23972.pd
Kif15 functions as an active mechanical ratchet
Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the mechanics of single Kif15 molecules under hindering or assisting loads and in a variety of nucleotide states. Whilst unloaded Kif15 is established to be highly processive, we find that under hindering loads, Kif15 takes <∼10 steps. As hindering load is increased, Kif15 forestep:backstep ratio decreases exponentially, with stall occurring at 6 pN. By contrast, under assisting loads, Kif15 detaches readily and rapidly, even from its AMPPNP state. Kif15 mechanics thus depend markedly on the loading direction. Kif15 interacts with a binding partner, Tpx2, and we show that Tpx2 locks Kif15 to microtubules under both hindering and assisting loads. Overall, our data predict that Kif15 in the central spindle will act as a mechanical ratchet, supporting spindle extension but resisting spindle compression
Tuning Magnetic Avalanches in Mn12-ac
Using micron-sized Hall sensor arrays to obtain time-resolved measurements of
the local magnetization, we report a systematic study in the molecular magnet
Mn-acetate of magnetic avalanches controllably triggered in different
fixed external magnetic fields and for different values of the initial
magnetization. The speeds of propagation of the spin-reversal fronts are in
good overall agreement with the theory of magnetic deflagration of Garanin and
Chudnovsky \cite{Garanin}.Comment: 8 pages, 7 figures; discussion expanded and revise
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