Relationship between seizures and metabolic acidosis: a prospective observational study

Objective: To assess changes in blood gas parameters, such as pH, partial carbon dioxide pressure (PaCO2), bicarbonate (HCO3), base deficit, and lactate values, in patients who present to the emergency care unit after aseizure. Methods: This is a prospective study on patients who suffered a generalized tonic-clonic seizure. The demographic and biochemical data of the patients and their blood gas parameters were recorded both at the time of presentation to the emergency department and during the follow-up examination. Results: A total of 68 patients were included in the study. Among the patients, 60.3% (41) were male. The median age of the patients was 43 years (IQR: 29-65.25). The median initial lactate value was 5.7 mmol/L (25th and 75th percentiles: 3.5–8.5 mmol/L). The median follow-up lactate value was 1.8 mmol/L (25th and 75th percentiles: 1.1–2.8 mmol/L). The statistical analysis of the blood gas parameters revealed a statistically significant difference in the pH, PaCO2, base deficit, and lactate values between the initial and follow-up evaluations (P<0.001). Conclusion: The results of our study suggest that metabolic acidosis with high anion gap may develop due to the increase in the lactate levels as a result of a tonic-clonic seizur

Depression and anxiety in chronic renal failure

Çocukların organik hastalıklara tepkisi; yaş, gelişim evresi, hastalığın getirdiği zorluklar, sağaltımın türü ve yan etkileri, kısıtlamalar, hastalığın algılanması, diğer insanların tepkileri, duygularını yeniden düzenleme ve kişilik gibi etmenlerin sonucu olarak gelişmektedir. Hemodiyaliz, son dönem böbrek yetmezliği olan çocuğun yaşamını uzatmış, ancak çocuğun hastalığa verdiği tepkileri de etkilemiştir. Bu çalışmada, Çocuklar İçin Depresyon Ölçeği ve Durumluk-Sürekli Kaygı Ölçeği ile son dönem böbrek yetmezliği olan ve hemodiyaliz sağaltımındaki 20 ergen değerlendirildi. Kronik böbrek yetmezliği olan ve konservatif sağaltım yöntemleri ile izlenen 20 ergenle karşılaştırıldı. Depresif belirti puanları ortalama değerlerde, kaygı puanları her iki grupta da yüksek olarak belirlendi. Sonuçlar, hemodiyaliz ve konservatif sağaltım alan hastaların depresyon ve kaygı puanları arasında istatiksel olarak anlamlı bir fark olmadığını göstermektedir.How children react to an illness is a reflection of their age; stage of development; discomfort from the illness; the type of treatment and its side effects; the limitations placed on them; their understanding of the illness; the reactions of other other persons and their emotional makeup and personality. Hemodialysis has prolonged the lifetime of children with endstage renal disease, but it effects most of the factors related with children reaction to the illness. In this study, State-Trait Anxiety Inventory and Depression Scale For Children administered to twenty adolescent with endstage renal disease who receive hemodialysis therapy, and as a control group twenty adolescent with chronic renal failure who had followed with conservative therapy. Depression scores were moderate , but anxiety scores were high in both groups. The results showed that the group receiving hemodialysis therapy and the group going on conservative therapy had no statistically difference according depression and anxiety scores

The p.Thr11Met mutation in c19orf12 is frequent among adult Turkish patients with MPAN

Introduction: Mutations in the C19orf12 gene cause mitochondrial membrane protein associated neurodegeneration (MPAN), an autosomal recessive form of neurodegeneration with brain iron accumulation (NBIA). A limited number of patients with C19orf12 mutations, particularly those with adult onset of symptoms, have been reported