126 research outputs found
Ductus venosus blood flow velocity characteristics of fetuses with single umbilical artery
Objectives: Sonographic Doppler evaluation of the fetal ductus venosus has been proved to be useful in the evaluation of fetal cardiac function. The aim of this study was to investigate the ductus venosus blood flow profile in fetuses with single umbilical artery and to correlate it with the umbilical cord morphology. Methods: Fetuses at > 20 weeks' gestation with single umbilical artery who were otherwise healthy were consecutively enrolled into the study. The sonographic examination included evaluation of the following Doppler parameters: umbilical artery resistance index, maximum blood flow velocity of the ductus venosus during ventricular systole (S-peak) and atrial contraction (A-wave), ductus venosus time-averaged maximum velocity (TAMXV), and pulsatility index for veins (PIV). The cross-sectional area of the umbilical cord and its vessels were measured in all cases. The Doppler and morphometric values obtained were plotted on reference ranges. Results: A total of 88 fetuses with single umbilical artery were scanned during the study period. Of these 52 met the inclusion criteria. The S-peak velocity, A-wave velocity, and TAMXV were below the 5th centile for gestational age in 57.7%, 59.6%, and 57.7% of cases, respectively. The PIV was within the normal range in 80.1% of cases. The umbilical vein cross-sectional area of fetuses with single umbilical artery was above the 95th centile for gestational age in 34.6% cases. Conclusions: The ductus venosus blood flow pattern is different in fetuses with single umbilical artery from that in those with a three-vessel cord. This difference may be caused in part by the particular morphology of umbilical cords with a single artery. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd
Distance dependence of force and dissipation in non-contact atomic force microscopy on Cu(100) and Al(111)
The dynamic characteristics of a tip oscillating in the nc-AFM mode in close
vicinity to a Cu(100)-surface are investigated by means of phase variation
experiments in the constant amplitude mode. The change of the quality factor
upon approaching the surface deduced from both frequency shift and excitation
versus phase curves yield to consistent values. The optimum phase is found to
be independent of distance. The dependence of the quality factor on distance is
related to 'true' damping, because artefacts related to phase misadjustment can
be excluded. The experimental results, as well as on-resonance measurements at
different bias voltages on an Al(111) surface, are compared to Joule
dissipation and to a model of dissipation in which long-range forces lead to
viscoelastic deformations
Probing the shape of atoms in real space
The structure of single atoms in real space is investigated by scanning
tunneling microscopy. Very high resolution is possible by a dramatic reduction
of the tip-sample distance. The instabilities which are normally encountered
when using small tip-sample distances are avoided by oscillating the tip of the
scanning tunneling microscope vertically with respect to the sample. The
surface atoms of Si(111)-(7 x 7) with their well-known electronic configuration
are used to image individual samarium, cobalt, iron and silicon atoms. The
resulting images resemble the charge density corresponding to 4f, 3d and 3p
atomic orbitals.Comment: Submitted to Phys. Rev. B, 17 pages, 7 figure
Interaction imaging with amplitude-dependence force spectroscopy
Knowledge of surface forces is the key to understanding a large number of
processes in fields ranging from physics to material science and biology. The
most common method to study surfaces is dynamic atomic force microscopy (AFM).
Dynamic AFM has been enormously successful in imaging surface topography, even
to atomic resolution, but the force between the AFM tip and the surface remains
unknown during imaging. Here, we present a new approach that combines high
accuracy force measurements and high resolution scanning. The method, called
amplitude-dependence force spectroscopy (ADFS) is based on the
amplitude-dependence of the cantilever's response near resonance and allows for
separate determination of both conservative and dissipative tip-surface
interactions. We use ADFS to quantitatively study and map the nano-mechanical
interaction between the AFM tip and heterogeneous polymer surfaces. ADFS is
compatible with commercial atomic force microscopes and we anticipate its
wide-spread use in taking AFM toward quantitative microscopy
Premelting of Thin Wires
Recent work has raised considerable interest on the nature of thin metallic
wires. We have investigated the melting behavior of thin cylindrical Pb wires
with the axis along a (110) direction, using molecular dynamics and a
well-tested many-body potential. We find that---in analogy with cluster
melting---the melting temperature of a wire with radius is lower
than that of a bulk solid, , by . Surface melting
effects, with formation of a thin skin of highly diffusive atoms at the wire
surface, is observed. The diffusivity is lower where the wire surface has a
flat, local (111) orientation, and higher at (110) and (100) rounded areas. The
possible relevance to recent results on non-rupturing thin necks between an STM
tip and a warm surface is addressed.Comment: 10 pages, 4 postscript figures are appended, RevTeX, SISSA Ref.
131/94/CM/S
An all silicon quantum computer
A solid-state implementation of a quantum computer composed entirely of
silicon is proposed. Qubits are Si-29 nuclear spins arranged as chains in a
Si-28 (spin-0) matrix with Larmor frequencies separated by a large magnetic
field gradient. No impurity dopants or electrical contacts are needed.
Initialization is accomplished by optical pumping, algorithmic cooling, and
pseudo-pure state techniques. Magnetic resonance force microscopy is used for
readout. This proposal takes advantage of many of the successful aspects of
solution NMR quantum computation, including ensemble measurement, RF control,
and long decoherence times, but it allows for more qubits and improved
initialization.Comment: ReVTeX 4, 5 pages, 2 figure
Advances in atomic force microscopy
This article reviews the progress of atomic force microscopy (AFM) in
ultra-high vacuum, starting with its invention and covering most of the recent
developments. Today, dynamic force microscopy allows to image surfaces of
conductors \emph{and} insulators in vacuum with atomic resolution. The mostly
used technique for atomic resolution AFM in vacuum is frequency modulation AFM
(FM-AFM). This technique, as well as other dynamic AFM methods, are explained
in detail in this article. In the last few years many groups have expanded the
empirical knowledge and deepened the theoretical understanding of FM-AFM.
Consequently, the spatial resolution and ease of use have been increased
dramatically. Vacuum AFM opens up new classes of experiments, ranging from
imaging of insulators with true atomic resolution to the measurement of forces
between individual atoms.Comment: In press (Reviews of Modern Physics, scheduled for July 2003), 86
pages, 44 figure
Immunochemotherapy With Obinutuzumab or Rituximab for Previously Untreated Follicular Lymphoma in the GALLIUM Study: Influence of Chemotherapy on Efficacy and Safety
PurposeThe GALLIUM study (ClinicalTrials.gov identifier: NCT01332968) showed that obinutuzumab (GA101;G) significantly prolonged progression-free survival (PFS) in previously untreated patients with follicular lymphoma relative to rituximab (R) when combined with cyclophosphamide (C), doxorubicin, vincristine (V), and prednisone (P;CHOP);CVP;or bendamustine. This report focuses on the impact of chemotherapy backbone on efficacy and safety.Patients and Methods: A total of 1,202 patients with previously untreated follicular lymphoma (grades 1 to 3a), advanced disease (stage III or IV, or stage II with tumor diameter 7 cm), Eastern Cooperative Oncology Group performance status 0 to 2, and requiring treatment were randomly assigned 1:1 to G 1,000 mg on days 1, 8, and 15 of cycle 1 and day 1 of subsequent cycles or R 375 mg/m(2) on day 1 of each cycle, for six to eight cycles, depending on chemotherapy (allocated nonrandomly by center). Responding patients received G or R for 2 years or until disease progression.Results: Baseline Follicular Lymphoma International Prognostic Index risk, bulky disease, and comorbidities differed by chemotherapy. After 41.1 months median follow-up, PFS (primary end point) was superior for G plus chemotherapy (overall hazard ratio [HR], 0.68;95% CI, 0.54 to 0.87;P = .0016), with consistent results across chemotherapy backbones (bendamustine: HR, 0.63;95% CI, 0.46 to 0.88;CHOP: HR, 0.72;95% CI, 0.48 to 1.10;CVP: HR, 0.79;95% CI, 0.42 to 1.47). Grade 3 to 5 adverse events, notably cytopenias, were most frequent with CHOP. Grade 3 to 5 infections and second neoplasms were most frequent with bendamustine, which was associated with marked and prolonged reductions in T-cell counts. Fatal events were more frequent in patients treated with bendamustine, possibly reflecting differences in patient risk profiles.Conclusion: Improved PFS was observed for G plus chemotherapy for all three chemotherapy backbones. Safety profiles differed, although comparisons are confounded by nonrandom chemotherapy allocation
Electrophysiological characterization of texture information slip-resistance dependent in the rat vibrissal nerve
<p>Abstract</p> <p>Background</p> <p>Studies in tactile discrimination agree that rats are able to learn a rough-smooth discrimination task by actively touching (whisking) objects with their vibrissae. In particular, we focus on recent evidence of how neurons at different levels of the sensory pathway carry information about tactile stimuli. Here, we analyzed the multifiber afferent discharge of one vibrissal nerve during active whisking. Vibrissae movements were induced by electrical stimulation of motor branches of the facial nerve. We used sandpapers of different grain size as roughness discrimination surfaces and we also consider the change of vibrissal slip-resistance as a way to improve tactile information acquisition. The amplitude of afferent activity was analyzed according to its Root Mean Square value (RMS). The comparisons among experimental situation were quantified by using the information theory.</p> <p>Results</p> <p>We found that the change of the vibrissal slip-resistance is a way to improve the roughness discrimination of surfaces. As roughness increased, the RMS values also increased in almost all cases. In addition, we observed a better discrimination performance in the retraction phase (maximum amount of information).</p> <p>Conclusions</p> <p>The evidence of amplitude changes due to roughness surfaces and slip-resistance levels allows to speculate that texture information is slip-resistance dependent at peripheral level.</p
Thermal Diffusion Processes in Metal-Tip-Surface Interactions: Contact Formation and Adatom Mobility
- …