The Cocoon Nebula and its ionizing star: do stellar and nebular abundances agree?

(Abridged) Main sequence massive stars embedded in an HII region should have the same chemical abundances as the surrounding nebular gas+dust. The Cocoon nebula, a close-by Galactic HII region ionized by a narrow line B0.5 V single star (BD+46 3474), is an ideal target to perform a detailed comparison of nebular and stellar abundances in the same Galactic HII region. We investigate the chemical content of O, N and S in the Cocoon nebula from two different points of view: an empirical analysis of the nebular spectrum and a detailed spectroscopic analysis of its ionizing B-type star using state-of-the-art stellar atmosphere modeling. By comparing the stellar and nebular abundances, we aim to indirectly address the long-standing problem of the discrepancy found between abundances obtained from collisionally excited lines (CELs) and optical recombination lines in photoionized nebulae. We collect spatially resolved spectroscopy of the Cocoon nebula and a high resolution optical spectrum of its ionizing star. Standard nebular techniques are used to compute the physical conditions and gaseous abundances of O, N and S. We perform a self-consistent spectroscopic abundance analysis of BD+46 3474 based on the atmosphere code FASTWIND to determine the stellar parameters and Si, O, and N abundances. The Cocoon nebula and its ionizing star, located at a distance of 800+-80 pc, have a very similar chemical composition as the Orion nebula and other B-type stars in the solar vicinity. This result agrees with the high degree of homogeneity of the present-day composition of the solar neighbourhood as derived from the study of the local cold-gas ISM. The comparison of stellar and nebular CELs abundances in the Cocoon nebula indicates that O and N gas+dust nebular values are in better agreement with stellar ones assuming small temperature fluctuations, of the order of those found in the Orion nebula.Comment: Accepted for publication in A&A. 13 pages, 7 tables and 6 figure

Catalogue of the morphological features in the Spitzer Survey of Stellar Structure in Galaxies (S4^4G)

A catalogue of the morphological features for the complete Spitzer Survey of Stellar Structure in Galaxies (S$^4$G), including 2352 nearby galaxies, is presented. The measurements are made using 3.6 $\mu$m images, largely tracing the old stellar population; at this wavelength the effects of dust are also minimal. The measured features are the sizes, ellipticities, and orientations of bars, rings, ringlenses, and lenses. Measured in a similar manner are also barlenses (lens-like structures embedded in the bars), which are not lenses in the usual sense, being rather the more face-on counterparts of the boxy/peanut structures in the edge-on view. In addition, pitch angles of spiral arm segments are measured for those galaxies where they can be reliably traced. More than one pitch angle may appear for a single galaxy. All measurements are made in a human-supervised manner so that attention is paid to each galaxy. We used isophotal analysis, unsharp masking, and fitting ellipses to measured structures. We find that the sizes of the inner rings and lenses normalized to barlength correlate with the galaxy mass: the normalized sizes increase toward the less massive galaxies; it has been suggested that this is related to the larger dark matter content in the bar region in these systems. Bars in the low mass galaxies are also less concentrated, likely to be connected to the mass cut-off in the appearance of the nuclear rings and lenses. We also show observational evidence that barlenses indeed form part of the bar, and that a large fraction of the inner lenses in the non-barred galaxies could be former barlenses in which the thin outer bar component has dissolved.Comment: 17 pages, 12 figures, accepted for publication in A&

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, we report crystal structures of RRM3 free and bound to cognate RNAs. Our structural, NMR and biochemical data show that RRM3 mediates canonical RNA interactions and reveal molecular details of a dimerization interface localized on the α-helical face of RRM3. NMR and SAXS analyses indicate that the three RRMs in full-length HuR are flexibly connected in the absence of RNA, while they adopt a more compact arrangement when bound to RNA. Based on these data and crystal structures of tandem RRM1,2-RNA and our RRM3-RNA complexes, we present a structural model of RNA recognition involving all three RRM domains of full-length HuR. Mutational analysis demonstrates that RRM3 dimerization and RNA binding is required for functional activity of full-length HuR in vitro and to regulate target mRNAs levels in human cells, thus providing a fine-tuning for HuR activity in vivo.España, MINECO BFU2015-71017España, Junta de Andalucía CVI-BIO198; P11-CVI7216 to I.D.M

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are protected from unscheduled DNA breaks remains unexplored. Here we define a checkpoint response to persistent meiotic DSBs in C. elegans that phosphorylates the synaptonemal complex (SC) to switch repair partner from the homolog to the sister chromatid. A key target of this response is the core SC component SYP-1, which is phosphorylated in response to ionizing radiation (IR) or unrepaired meiotic DSBs. Failure to phosphorylate (syp-16A) or dephosphorylate (syp-16D) SYP-1 in response to DNA damage results in chromosome non-dysjunction, hyper-sensitivity to IR-induced DSBs, and synthetic lethality with loss of brc-1BRCA1. Since BRC-1 is required for inter-sister repair, these observations reveal that checkpoint-dependent SYP-1 phosphorylation safeguards the germline against persistent meiotic DSBs by channelling repair to the sister chromatid.Cancer Research UK FC0010048UK Medical Research Council FC0010048Wellcome Trust FC0010048Ministerio de Economía y Competitividad BFU2016-75058-PEuropean Research Council ERC2014 AdG669898 TARLOO

Statistical analysis of Ni nanowires breaking processes: a numerical simulation study

A statistical analysis of the breaking behavior of Ni nanowires is presented. Using molecular dynamic simulations, we have determined the time evolution of both the nanowire atomic structure and its minimum cross section (Sm(t)). Accumulating thousands of independent breaking events, Sm histograms are built and used to study the influence of the temperature, the crystalline stretching direction and the initial nanowire size. The proportion of monomers, dimers and more complex structures at the latest stages of the breaking process are calculated, finding important differences among results obtained for different nanowire orientations and sizes. Three main cases have been observed. (A) [111] stretching direction and large nanowire sizes: the wire evolves from more complex structures to monomers and dimers prior its rupture; well ordered structures is presented during the breaking process. (B) Large nanowires stretched along the [100] and [110] directions: the system mainly breaks from complex structures (low probability of finding monomers and dimers), having disordered regions during their breakage; at room temperature, a huge histogram peak around Sm=5 appears, showing the presence of long staggered pentagonal Ni wires with ...-5-1-5-... structure. (C) Initial wire size is small: strong size effects independently on the temperature and stretching direction. Finally, the local structure around monomers and dimmers do not depend on the stretching direction. These configurations differ from those usually chosen in static studies of conductance.Comment: 18 pages, 13 figure

Diagnóstico geoecológico como base para el ordenamiento de un territorio: Parque Metropolitano de La Habana

The development of the cities decrease the potencial of green areas. The population require that spaces for its amusement and recreation and also in order to be evident the esthetics and natural values. These aspects will be considered in the planning and management of those places that still keep environment value. According with those ideas the public administration of the city put up the Metropolitan Park of Habana. Its territory had been divided into units of landscape and studied by some gauges or index which allowed to establish the geoecological diagnostic of the territory and to program measures for its planning.El crecimiento de las ciudades reduce el potencial de espacios verdes en ellas, por lo que la demanda de espacios de uso recreativo, con tendencia a resaltar los valores naturales y estéticos, deben ser considerados en la planificación y gestión de aquellos lugares que aun conserven un valor ambiental. Teniendo en cuenta esas premisas, se crea el Parque Mletroplitano de La Habana, en el que se elabora una zonificación basada en un mapa de unidades de paisaje que son analizadas mediante indicadores que permiten establecer el diagnóstico geoecológico de todo el territorio, y programar medidas para su ordenamiento

First observation of the cosmic ray shadow of the Moon and the Sun with KM3NeT/ORCA

This article reports the first observation of the Moon and the Sun shadows in the sky distribution of cosmic-ray induced muons measured by the KM3NeT/ORCA detector. The analysed data-taking period spans from February 2020 to November 2021, when the detector had 6 Detection Units deployed at the bottom of the Mediterranean Sea, each composed of 18 Digital Optical Modules. The shadows induced by the Moon and the Sun were detected at their nominal position with a statistical significance of 4.2 and 6.2 , and an angular resolution of and , respectively, consistent with the prediction of from simulations. This early result confirms the effectiveness of the detector calibration, in time, position and orientation and the accuracy of the event direction reconstruction. This also demonstrates the performance and the competitiveness of the detector in terms of pointing accuracy and angular resolution.Agence Nationale de la Recherche (ANR) ANR-15-CE31-0020Centre National de la Recherche Scientifique (CNRS)Commission Europeenne (FEDER fund), FranceMarie Curie Actions European Union (EU)Institut Universitaire de France (IUF), FranceLabEx UnivEarthS, France ANR-10-LABX-0023 ANR-18-IDEX-0001Paris ile-de-France Region, FranceGerman Research Foundation (DFG)Greek Ministry of Development-GSRTIstituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program Italy NAT-NET 2017W4HA7SMinistry of Higher Education, Scientific Research and Innovation, MoroccoArab Fund for Economic and Social DevelopmentNetherlands Organization for Scientific Research (NWO) Netherlands GovernmentNational Science Centre, PolandNational Authority for Scientific Research (ANCS), RomaniaMCIN/AEI PID2021-124591NB-C41 PID2021-124591NB-C42 PID2021-124591NB-C43ERDF A way of making EuropeEuropean Union (EU)Center for Forestry Research & Experimentation (CIEF) ASFAE/2022/023 ASFAE/2022/014Programa Prometeo of the Generalitat Valenciana PROMETEO/2020/019GenT of the Generalitat Valenciana CIDEGENT/2018/034 CIDEGENT/2019/043 CIDEGENT/2020/049 CIDEGENT/2021/23Junta de Andalucia SOMM17/6104/UGR P18-FR-5057EU: MSC program 101025085Programa Maria Zambrano (Spanish Ministry of Universities - European Union, NextGenerationEU), Spai