Lactic Acid Bacteria and Yeast Inocula Modulate the Volatile Profile of Spanish-Style Green Table Olive Fermentations

In this work, Manzanilla Spanish-style green table olive fermentations were inoculated with Lactobacillus pentosus LPG1, Lactobacillus pentosus Lp13, Lactobacillus plantarum Lpl15, the yeast Wickerhanomyces anomalus Y12 and a mixed culture of all them. After fermentation (65 days), their volatile profiles in brines were determined by gas chromatography-mass spectrometry analysis. A total of 131 volatile compounds were found, but only 71 showed statistical differences between at least, two fermentation processes. The major chemical groups were alcohols (32), ketones (14), aldehydes (nine), and volatile phenols (nine). Results showed that inoculation with Lactobacillus strains, especially L. pentosus Lp13, reduced the formation of volatile compounds. On the contrary, inoculation with W. anomalus Y12 increased their concentrations with respect to the spontaneous process, mainly of 1-butanol, 2-phenylethyl acetate, ethanol, and 2-methyl-1-butanol. Furthermore, biplot and biclustering analyses segregated fermentations inoculated with Lp13 and Y12 from the rest of the processes. The use of sequential lactic acid bacteria and yeasts inocula, or their mixture, in Spanish-style green table olive fermentation could be advisable practice for producing differentiated and high-quality products with improved aromatic profile.Gobierno de España-OliFilm-AGL-2013-48300-

Deletion Syndrome 22q11.2: A Systematic Review

22q11.2 deletion syndrome (DS 22q11.2) is a rare disease of genetic origin, caused by the loss of the q11.2 region of chromosome 22. It affects one in 4000 live newborns, and among the clinical manifestations that can occur in this syndrome are abnormalities in the parathyroid glands (producing calcium deficits), the palate, the heart and the thymus. It is also known as DiGeorge syndrome or velocardiofacial syndrome, among other names, depending on the clinical presentation of each individual. The main objective of the review was to update information on DS 22q11.2 from publications in the scientific literature. The daily activities of these patients are seriously impaired, due to the impact of the clinical manifestations. Interventions can be performed to improve their social, cognitive and emotional skills, thus increasing their ability to perform different daily activities.Colegio Oficial de Enfermeria de Granada (CODEGRA

Anti-High-Density Lipoprotein Antibodies and Antioxidant Dysfunction in Immune-Driven Diseases

This work was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (FIS, PI12/00523 and PI16/0011; ISCIII, Spain). JR-C is supported by a postdoctoral contract from the “Juan de la Cierva” program (FJCI-2015-23849; MICINN, Spain)

LOS OBJETIVOS POR COMPETENCIAS DOCENTES EN EL PLAN DE ESTUDIO E, DE LA CARRERA DE MARXISMO LENINISMO E HISTORIA / THE OBJECTIVES FOR TEACHING COMPETENCES IN THE STUDY PLAN E, OF THE CAREER OF MARXISM LENINISM AND HISTORY

El artículo se fundamenta como resultado del trabajo docente metodológico durante la elaboración del Plan del Proceso docente, del Plan de Estudio E, en la carrera de Marxismo Leninismo e Historia en la concepción curricular para la formación del futuro profesional, sostenido por las bases del currículo y sus presupuestos en la propuesta del nuevo plan de Estudio, se concreta en una análisis teórico del diseño de los objetivos en la carrera por competencias profesionales a partir de resultados científico consultados en este aspecto, se argumentan las ventajas que tiene este tipo de diseño de objetivo y se demuestra que los objetivos generales en la carrera se evidencian en la nueva formulación y se enriquecen con nuevos indicadores, el artículo tiene como finalidad proponer los objetivos por competencias docentes, en la carrera de Marxismo Leninismo e Histori

Unperceived dating violence among Mexican students

El presente estudio, ex post facto de tipo prospectivo, tiene como objetivo establecer la autopercepción de maltrato, así como los sentimientos de miedo y atrapado que existen entre los miembros de una relación de pareja, y determinar si hay diferencias en la prevalencia de los diferentes tipos de violencia o victimización entre los que se perciben maltratados y los que no, teniendo en cuenta las combinaciones con la sensación de miedo y atrapamiento. Participaron 3.495 estudiantes mexicanos de los cuales 1.927 son preuniversitarios (edad media = 20,16; DT = 2,13) y 1.568 universitarios (edad media = 15,99; DT = 1,64). Se aplicaron un cuestionario de datos sociodemográficos y el Cuestionario de Violencia de Novios (CUVINO). El 88% de los participantes no se percibe como maltratado por su pareja, pero el 15,2% ha sentido miedo y el 27% asevera haberse sentido en algún momento atrapado en la relación. Los datos ponen de manifiesto que una importante mayoría de jóvenes del estudio presenta maltrato técnico, ya que aun cuando se autoperciben como no maltratados presentan la evidencia de haber vivido abuso en su relación de noviazgo.The aim of this ex post facto study was to determine the level of self-perceived abuse and the feelings of fear and entrapment that exist among Mexican students in a dating relationship. We intended to explore possible differences in the prevalence of the various types of violence or victimization between individuals who perceive themselves as being abused and those who do not, combining such perceptions with the feelings of fear and entrapment. The sample was composed of 3,495 Mexican students, of which 1,927 were pre-university students (M= 20.16; SD= 2.13) and 1,568 were university students (M= 15.99; SD= 1.64). We applied a questionnaire on socio-demographic data and the Cuestionario de Violencia entre Novios (CUVINO, Dating Violence Questionnaire). Results showed that 88% of participants did not feel abused by their boyfriend or girlfriend; yet, 15.2% reported having been afraid and 27% reported having felt trapped in the relationship at some point. The data revealed that a considerable majority of youth in the sample had been victims of unperceived abuse. More specifically, they presented evidence of having experienced abuse in their dating relationship even when they described themselves as not being abused

Ehlers–Danlos Syndrome Type Arthrochalasia: A Systematic Review

Ehlers–Danlos syndrome type arthrochalasia (aEDS) is a rare genetic disease characterized by severe generalized joint hypermobility, bilateral congenital hip dislocation, skin hyperextensibility, muscle hypotonia, and mild dysmorphic features. It is an autosomal dominant connective tissue disease causing defects in collagen, associated with two genes, COL1A1 or COL1A2. Only about 42 cases have been published worldwide. Treatment is currently symptomatic and focuses on increasing the quality of life of these patients, as there is no curative treatment. The main objective of the review was to update information on Ehlers–Danlos syndrome type arthrochalasia from scientific publications. The review report was carried out in accordance with the criteria of the Preferred Reporting Items for Systematic reviews and MetaAnalyses (PRISMA) review protocol, by searching Orphanet, OMIM, PubMed, and Scopus, as well as free sources. A total of 20 articles were analyzed, which, after analysis, provide an updated report that aims to establish a solid starting point for future lines of research

Depression and Anxiety in Patients with Rare Diseases during the COVID-19 Pandemic

The research group behind this project wishes to thank the following associations for their collaboration in the distribution of the study questionnaire: Asogaf–Asociación Granadina de la Ataxia de Friedreich. Asociación de Enfermos Musculares de Granada. AGRADA Asociación de Ataxias de Granada. Asociación española de afectados por Epilepsia Grave. Phelan Mcdermid. 22q13. Asociación Síndrome Shy Drager–Atrofia Multisistémica. Adisen–Asociación Nacional de Addison y Otras Enfermedades Endocrinas. ASENCO, Asociación de Enfermedades Neuromusculares de Córdoba. Asociación 22 q Andalucía. Asociación Andaluza de Esclerosis Lateral Amiotrófica. Asociación Andaluza de Fibrosis Quística. Asociación Andaluza de Hemofilia. Asociación Cordobesa para la Investigación de Corea de Huntington. Asociación de Enfermedades Neuromusculares de Andalucía. Asociación de Enfermos con Neurodegeneración por Acumulación Cerebral de Hierro. Asociación de Familiares y Afectados Síndrome de Coffin-Lowry España. Asociación de Retinosis Pigmentaria de Andalucía. Asociación del Síndrome de Prader Willi de Andalucía. Asociación Española de Enfermos por Pseudoxantoma Elástico. Asociación Española de Familiares y Enfermos de Wilson. Asociación Española para la Investigación y Ayuda al Síndrome de Wolfram. Asociación Síndrome de Turner de Andalucía. Asociación Sindrome de Williams de Andalucía. Asociación Valverdeña de la Enfermedad de Andrade. DEBRA Piel de Mariposa (Asociación de Epidermólisis Bullosa de España). Federación Andaluza de Asociaciones de Ataxias. Asociación de Atrofia del Nervio Óptico de Léber. Acción y Cura para Tay Sachs. ACTAYS. Asociación 11q España. Asociación AMC–Artrogriposis Múltiple Congénita–España. Asociación de Afectados de Neurofibromatosis. Asociación de Afectados Síndrome Landau –Kleffner. Asociación de Apoyo e Investigación del Síndrome de 5p-. Asociación de Corea de Huntington Española. Asociación de Enfermedades Raras de Alcalá de Henares. Asociación de Enfermos de Patología Mitocondrial. Asociacion de Familias con Perthes. Asociación Española de Porfiria. Asociación Española del Síndrome de Beckwith– Wiedemann. Asociación Española del Síndrome de Joubert. Asociación Huesos de Cristal de España. Asociación Nacional Síndrome de Apert y otras Craneosinostosis Sindrómicas. Asociación de Enfermedades Raras D’Genes. FEGEREC–Federación Gallega de enfermedades raras. Asociación Chiari y Siringomielia del Principado de Asturias (CHySPA). Asociación Asturiana contra la Fibrosis Quística (F.Q.). Asociación Ataxias de Extremadura. Asociación de Retinosis Pigmentaria Extremeña. Asociación ELA Extremadura. Asociación Española de Cavernomas. Asociación Española de Lucha contra las Hemoglobinopatias y Talasemias. Asociación Española de Stickler. Asociación Extremeña contra la Fibrosis Quística. Asociación Extremeña de Enfermos de Huntington. Asociación La Vida con Hernia Diafragmática Congénita. Asociación PrincesaRett. Asociación Síndrome X Frágil de Extremadura. Alba, Asociación de Ayuda a Personas con Albinismo. Asociación “Síndrome de Microdeleción 5q14.3–MEF2C”. Asociación ADIBI. Asociación de Discapacitados y Enfermedades Raras de IBI. Asociación Afectados CDKL5. Asociación Conquistando Escalones. Asociación de Enfermedades Minoritarias de la Comunidad Valenciana. Asociación de Enfermedades Raras de Benidorm y Comarca. Asociación de enfermedades raras y discapacidad Sense Barreres de Petrer. Asociación de enfermos de FMF y síndromes autoinflamatorios de España. Asociación de Esclerodermia Castellón. Asociación de Fibrosis Quística de la Comunidad Valenciana. Asociación de lucha contra la Distonía Mioclónica de Valencia. Asociación de Microsomia Hemifacial. Asociación de Padres de Niños y Jóvenes con Enfermedades Reumáticas de la Comunidad Valenciana. Asociación CADASIL España. Asociación Catalana de Espina Bífida e Hidrocefalia. Asociación Duchenne Somriures Valents. Asociación Española de Enfermos del Síndrome de Camurati–Engelmann. Asociación Española del Síndrome de Cornelia de Lange. Asociación Microtia España. Asociación Síndrome STXBP1. Associació Catalana de la Síndrome de Rett. Associació Catalana de Malaltia de Huntington.Scientific knowledge on depression and anxiety in patients with rare diseases during the COVID-19 pandemic is scarce; however, it is essential to perform comprehensive management of these patients. The aim of this study was to research how the situation caused by the SARS-CoV-2 pandemic has influenced the lives of patients with rare diseases regarding depression and anxiety. This Spanish study considered a heterogeneous population sample of 86 patients with confirmed diagnosis of different rare diseases. Participants took part in a cross-sectional online study by completing specific questionnaires on the study topic. Depression was measured using the Patient Health Questionnaire (PHQ-9), and the General Anxiety Disorder Scale (GAD-7) was used for evaluating anxiety. Data collection through an online questionnaire allowed for a greater population scope and therefore the inclusion patients of other nationalities in the study sample. Finally, as a general result, this study found that, in the face of the pandemic, anxiety and depression remained at a higher level in this group than in the general population, making these patients a vulnerable population group

AER tools for Communications and Debugging

Address-event-representation (AER) is a communications protocol for transferring spikes between bio-inspired chips. Such systems may consist of a hierarchical structure with several chips that transmit spikes among them in real time, while performing some processing. To develop and test AER based systems it is convenient to have a set of instruments that would allow to: generate AER streams, monitor the output produced by neural chips and modify the spike stream produced by an emitting chip to adapt it to the requirements of the receiving elements. In this paper we present a set of tools that implement these functions developed in the CAVIAR EU projectUnión Europea IST-2001-34124 (CAVIAR)Ministerio de Ciencia y Tecnología TIC-2003-08164-C03-0

Tolerance of abuse within Mexican adolescent relationships

Violence in interpersonal relationships in young people has been the subject of several studies in recent years. Studies of dating violence show that one of the resources available for the young to help perceive and distinguish abusive or violent behaviour is an indicator which increases the ability to recognise as well as confront the reality of abuse. Certain violent behaviour however can be perceived as non-abusive, where the victim and the aggressor can share an abnormal view of the relationship in which possession, jealousy and exclusivity are considered significant elements within the relationship. The objective of this study is to understand and establish the levels of aggravation (degree of tolerance) towards violent behaviour in relationships of engaged adolescent Mexicans affected by abuse, by considering gender and level of perception of abuse as variables. The sample was formed of 3304 young Mexican students between the ages of 13 and 22, containing 1432 boys and 1872 girls, 1383 pursuing university studies, whereas the remaining 1921 were pre-university students. CUVINO was administered in order to determine the abusive conduct and levels of discomfort (tolerance), which allowed us to observe that the highest levels of discomfort, greater than those caused by any other kind of abuse, are experienced by women, especially regarding sexual victimization within the category of those non-abused women that presented a lower level of tolerance. This finding led us to identify, as a major risk factor, those men and women with a high level of tolerance, who did not perceive themselves as having been abused.AECID (CYTED) AP/035718/1

Real time multiple objects tracking based on a bioinspired processing cascade architecture

This paper presents a cascade architecture for bio-inspired information processing. We use AER (Address Event Representation) for transmitting and processing visual information provided by an asynchronous temporal contrast silicon retina. Using this architecture, we also present a multiple objects tracking algorithm; this algorithm is described in VHDL and implemented in a FPGA (Spartan II), which is part of the USB-AER platform developed by some of the authors.Junta de Andalucía P06-TIC-02298Ministerio de Ciencia e Innovación TEC2009-10639-C04-02Junta de Andalucía P06-TIC-0141