5 research outputs found
ESTEROLES PRESENTES EN EL EXTRACTO APOLAR DE LAS RAĂŤCES DE AJO SACHA Mansoa alliacea
From the apolar extract of the roots of garlic Sacha Mansoa alliacea collected in the Botanical garden of Center of Rehabilitation of addictions and research of traditional medicines – Takiwasi (Tarapoto, San Martin region, in the Peruvian Amazon) identified stigmasterol (90,36 %) and Îł-sitosterol (8,76 %) as their main sterols, wich were analyzed by gas chromatography and identified by their mass spectra. In addition, was the qualitative analisys of the secondary metabolites.A partir del extracto apolar de las raĂces de Ajo sacha Mansoa alliacea colectadas en el JardĂn Botánico del Centro de RehabilitaciĂłn de Adicciones y de InvestigaciĂłn de Medicinas Tradicionales - Takiwasi (Tarapoto, regiĂłn San MartĂn, en la AmazonĂa peruana) se identificaron el estigmasterol (90,36 %) y el Îł- sitosterol (8,76 %) como sus principales esteroles, los cuales fueron analizados mediante cromatografĂa de gases e identificados mediante sus espectros de masas. Adicionalmente, se realizĂł el análisis cualitativo de sus metabolitos secundarios
Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.
Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction demonstrated high antioxidant activities (CE50=41.91 µg/mL) by DPPH in comparison with Trolox(r) and 11.33 mmol Trolox(r) equivalent by ORAC. In conclusion, the HE and FAE from K. pinnata displayed gastroprotective activity in rats, most likely due to the presence of flavonoids
Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.
ABSTRACT Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction demonstrated high antioxidant activities (CE50=41.91 µg/mL) by DPPH in comparison with Trolox(r) and 11.33 mmol Trolox(r) equivalent by ORAC. In conclusion, the HE and FAE from K. pinnata displayed gastroprotective activity in rats, most likely due to the presence of flavonoids