Ability of different flow rates of fractional exaled nitric oxide (FeNO) to discriminate between asthmatic and no asthamatic subject

Background: Nitric oxide (NO) is a gaseous molecule produced by certain cell types in an inflammatory response.The Fraction of exhaled NO (FeNO) is an aspecic, non-invasivebiomarker that can be used for asthma diagnosis, follow-up andtherapy; it correlates with bronchial hyperresponsiveness and withsputum eosinophilia [Kaiser et al. 2008, Taylor et al. 2006].To measure FeNO in exhaled air, subjects are asked to inhale NOfree air deeply to total lung capacity through a lter connected to ananalyzer, and to exhale slowly through the lter for 10s.Different expiratory flow rates are ensured by placing expiratoryresistors in the exhalation circuit, which yield expiratory flow rates of 50, 100, 200 and 250 ml/s.FeNO:1. is usually modied by smoking habits and asthma2. is usually higher in atopic subjects3. is flow-dependent (higher at lower flow rates and viceversa)Measurements are normally set up at 50 ml/s, but the flow rate that better discriminates between asthmatic and non asthmatic subjects is still unknown.Aim: To test the power of different flow rates of FeNO to discriminate between asthmatic subjects and controls.Conclusion:FeNO 100: best performance.FeNO 50 and FeNO 100 have a similar validity in identifying subjects with current asthma.FeNO 100 has a statistically significant greater AUR than FeNO200 and than FeNO 250

Thermally and Dynamically Driven Atmospheric Circulations over Heterogeneous Atmospheric Boundary Layer: Support for Safety Protocols and Environment Management at Nuclear Central Areas

Ilha Grande Bay is located in Angra dos Reis, Rio de Janeiro State, Brazil. The area is characterized by different land cover, complex topography and proximity to the Atlantic Ocean. These aspects make it susceptible to thermally and dynamically induced atmospheric circulations such as those associated with valley/mountain and land/sea breeze systems, among others. The Almirante \uc1lvaro Alberto Nuclear Complex (CNAAA) is located in this region, with a total of two nuclear power plants (NPPs) in operation in the Brazilian territory, Angra I and Angra II. Therefore, knowledge of local atmospheric circulation has become a matter of national and international security. Considering the importance of the meteorological security tool as a support for licensing, installation, routine operation and nuclear accident mitigation, the main aim of this study is the development of combined strategies of environmental statistical modeling in the analysis of thermally and dynamically driven atmospheric circulations over mountainous and coastal environments. We identified and hierarchized the influence of the thermally and mechanically driven forcing on the wind regime and stability conditions in the coastal atmospheric boundary layer over the complex topography region. A meteorological network of ground-based instruments was used along with physiographic information for the observational characterization of the atmospheric patterns in the spatial and time\u2013frequency domain. The predominant wind directions and intensity are attributed to the combined action of multiscale weather systems, notably, the valley/mountain and continent/ocean breeze circulations, the forced channeling due to valley axis orientation, the influence of the synoptic scale systems and atmospheric thermal tide. The observational investigation of the combined influence of terrain effects and meteorological systems aimed to understand the local atmospheric circulation serves as support for safety protocols of the NPPs, contemplating operation and environmental management. The importance of the study for the adequacy and skill evaluation of computational modeling systems for atmospheric dispersion of pollutants such as radionuclide and conventional contaminants can be also highlighted, in order that such systems are used as tools for environmental planning and managing nuclear operations, particularly those located in regions over mountainous and coastal environments with a heterogeneous atmospheric boundary layer

The detection of neutrino interactions in the emulsion/lead target of the OPERA experiment

The OPERA neutrino detector in the underground Gran Sasso Laboratory (LNGS) was designed to perform the first detection of neutrino oscillations in appearance mode through the study of \u3bd\u3bc\u2192 \u3bd\u3c4 oscillations. The apparatus consists of an emulsion/lead target complemented by electronic detectors and it is placed in the high energy long-baseline CERN to LNGS beam (CNGS) 730 km away from the neutrino source. Runs with CNGS neutrinos were successfully carried out in 2007 and 2008 with the detector fully operational with its related facilities for the emulsion handling and analysis. After a brief description of the beam and of the experimental setup we report on the collection, reconstruction and analysis procedures of first samples of neutrino interaction event

Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats

Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are com- monly used for testing close paternal relationships among individuals and populations, and for male lineage iden- tification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strik- ingly, >99% of the 12,272 unrelated males were com- pletely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836\u20130.9999988). Haplotype sharing between populations was almost ab- sent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in ur- ban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs,29% were differentiated including 27% of the 2,378 father\u2013son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and over- all male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database