Actes officiels d’attribution de médailles d’honneur à Paul Pascal - Ordre national de la Légion d'honneur - 1917, 1947, 1953, 1957 et 1964

Chevalier de la Légion d'honneur : 12 juillet 1917 Officier de la Légion d'honneur : 14 mars 1947 Commandeur de la Légion d'honneur : 17 septembre 1953 Commandeur dans l'Ordre des Palmes académiques : 5 juillet 1957 Grand officier de la Légion d'honneur : 11 juillet 196

Pharmacokinetics and Pharmacodynamics of Pipecuronium in Patients With Cirrhosis

To determine the effect of liver cirrhosis on the pharmacokinetics and pharmacodynamics of pipecuronium, the authors administered 100 mug/kg of pipecuronium intravenously to eight patients with liver cirrhosis and eight patients with normal liver and renal function undergoing elective abdominal surgery. All patients were anesthetized with thiopental (5-7 mg/kg), nitrous oxide (50-70% in oxygen), and fentanyl in repeated doses (2 mug/kg). Plasma concentrations of pipecuronium were determined by high-pressure liquid chromatography. A two-compartment open model was used for pharmacokinetic analysis. Thumb-elicited mechanical response to single-twitch ulnar nerve stimulation was also measured. Total plasma clearance did not differ between controls (2.96 +/- 1.05 mL.min-1.kg-1, mean +/- SD) and cirrhotics (2.61 +/- 1.16 mL.min-1.kg-1). Terminal elimination half-life was 111 +/- 46 min in controls and 143 +/- 25 min in cirrhotics. The total apparent volume of distribution at steady state did not differ between controls (350 +/- 81 mL/kg) and cirrhotics (452 +/- 222 mL/kg). The volume of the central compartment was not different between the two groups. The onset of neuromuscular blocking effect was longer in cirrhotics (233 +/- 112 s) (P <0.05) than in controls (170 +/- 33 s). The clinical duration (injection until single twitch returned to 25%) was similar between the two groups: 167 +/- 41 min in controls and 165 +/- 48 min in cirrhotics. The authors conclude that hepatic insufficiency due to cirrhosis does not alter the pharmacokinetics and pharmacodynamics of pipecuronium (100 mug/kg)

Notice

Avec mode text

Diario mercantil de Cádiz: Número 3459 - 1826 enero 27

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

[Bibliothèque impériale, cour d'honneur]. 2, BIBLIOTHEQUE IMPERIALE // Détail de l'Egout Cour Louvois : Attachement // de Maçonnerie N° 37 // F. Vernaud Entrepreneur : Exercice 1869 // M.r Labrouste Architecte : [dessin, plan] / [Agence des travaux de la Bibliothèque Impériale]

Référence bibliographique : Le Coeur, Labrouste, 672Appartient à l’ensemble documentaire : Des19LabrAttachement (architecture

[Bibliothèque nationale, cour d'honneur, aile Sud]. 15, « Bibliothèque Imp.ale // Porte d'entrée du Vestibule // conduisant à la G.de salle de lecture : [dessin, plan] / [Henri Labrouste]

Référence bibliographique : Le Coeur, Labrouste, 314Appartient à l’ensemble documentaire : Des19LabrÉlévatio