Technology, Information Production, and Market Efficiency

A well functioning securities market relies on the availability of accurate information, a broad base of investors who can process this information, legal protection of these investors’ rights, and a liquid secondary market unencumbered by excessive transaction costs or constraints. When these conditions are satisfied, securities markets are likely to be broader and more efficient, with felicitous consequences for investment and resource allocation. This paper explores the effect of technological advances on these features of the market, emphasizing the incentives facing the producers of financial information.

Developing an organic strategy of change to challenge gendered stereotypes around the technological (in)ability of women in architecture

Architecture is characterised by a lack of women in the profession and a significant drop–out after qualification all over Europe, despite decades of policies of inclusion. The practice of architecture requires the use of specialised instruments and technologies that often collide with the social assumptions and stereotypes around the conflicted relationship between women and technology. Women are socially perceived as inadequate users of technology in terms of: knowledge of the specific characteristics of objects, ability to use an instrument other than for its basic outcomes, and capacity to use technology in collaboration with co–workers. What can be done to challenge this widespread social perception? The suggestion offered here is to develop an organic strategy of combined actions able to foster a simultaneous change on different levels: individual, relational, cultural and structural. The paper offers an outline of a possible framework of analysis to be initially applied to the architectural field as a specific case study, with the possibility to subsequently adapt it to other STEM sectors. The framework draws upon the concepts of Technologically Dense Environments and Integral Theory’s AQAL method, used respectively to collect and organise empirical data

Triple or dual therapy for HCV-1 naive patients? Optimizing selection tools

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Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis

The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450