Life cycle analysis of road construction and use

Both the construction and use of roads have a range of environmental impacts; therefore, it is important to assess the sources of their burdens to adopt correct mitigation policies. Life cycle analysis (LCA) is a useful method to obtain demonstrable, accurate and non-misleading information for decision-making experts. The study presents a "cradle to gate with options" LCA of a provincial road during 60 year-service life. Input data derive from the bill of quantity of the project and their impacts have been evaluated according to the European standard EN 15804. The study considers the impacts of the construction and maintenance stages, lighting, and use of the vehicles on the built road. The results obtained from a SimaPro model highlight that the almost half of impacts took place during the construction stage rather than the use stage. Therefore, the adoption of environmentally friendly road planning procedures, the use of low-impact procedures in the production of materials, and the use of secondary raw materials could have the largest potential for reducing environmental impacts

New patents on topical anesthetics.

Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected. General anesthesia is a reversible state of unconsciousness produced by anesthetic agents, characterized by amnesia, muscle relaxation and loss of sensitivity to pain of the whole body. General anesthetic drugs can be classified into two main groups according to their predominant molecular pharmacological effects: volatile and intravenous agents. Local anesthesia produce a reversible loss of sensation in a portion of the body and it reversibly block impulse conduction along nerve axons and other excitable membrane. All local anesthetics (LA) are membrane stabilizing drugs; they reversibly decrease the rate of depolarization and repolarization of excitable membranes. They act mainly by inhibiting sodium influx through sodium-specific ion channels in the neuronal cell membrane, in particular the voltage-gated sodium channels. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is inhibited. The main local anesthetic (LA) agents for skin anesthesia are benzocaine (aminoester), prilocaine and lidocaine (aminoamides) which are commercially available as gels, ointments and creams (benzocaine and eutectic mixture of lidocaine and prilocaine) or as a bioadhesive (lidocaine) with different compositions (vehicles and excipients) for adults or pediatric use. Topical anesthetics decrease anxiety, pain and discomfort during cutaneous procedures and provide effective analgesia with rapid onset, prolonged duration and minimal side effects. This article outlines the different classes of topical anesthetics available and gives an overview of the mechanism of action, metabolism of each different class, of the possible complications that can occur because of their use and their possible treatment options and new patents. © 2014 Bentham Science Publishers

Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise

Of wide interest for health is the relation existing between depression, a very common psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult neurogenesis. We will focus on two neurogenic stimuli, fluoxetine and physical exercise, both endowed with the ability to activate adult neurogenesis in the dentate gyrus of the hippocampus, known to be required for learning and memory, and both able to counteract depression. Fluoxetine belongs to the class of selective serotonin reuptake inhibitor (SSRI) antidepressants, which represent the most used pharmacological therapy; physical exercise has also been shown to effectively counteract depression symptoms in rodents as well as in humans. While there is evidence that the antidepressant effect of fluoxetine requires its pro-neurogenic action, exerted by promoting proliferation, differentiation and survival of progenitor cells of the hippocampus, on the other hand fluoxetine exerts also neurogenesis-independent antidepressant effects by influencing the plasticity of the new neurons generated. Similarly, the antidepressant action of running also correlates with an increase of hippocampal neurogenesis and plasticity, although the gene pathways involved are only partially coincident with those of fluoxetine, such as those involved in serotonin metabolism and synapse formation. We further discuss how extra-neurogenic actions are also suggested by the fact that, unlike running, fluoxetine is unable to stimulate neurogenesis during aging, but still displays antidepressant effects. Moreover, in specific conditions, fluoxetine or running activate not only progenitor but also stem cells, which normally are not stimulated; this fact reveals how stem cells have a long-term, hidden ability to self-renew and, more generally, that neurogenesis is subject to complex controls that may play a role in depression, such as the type of neurogenic stimulus or the state of the local niche. Finally, we discuss how fluoxetine or running are effective in counteracting depression originated from stress or neurodegenerative diseases

Proposal for a methodology based on XRD and SEM-EDS to monitor effects of lime-treatment on clayey soils

The aim of this paper is to present the results of X-ray diffraction (XRD) tests and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS) analyses on a natural and lime-treated clay, in order to determine the percentage of lime able to stabilize soil. For this reason, XRD test analyses have been conducted on natural soil (TQ0) and on two different mixtures (TQ3 and TQ5): The former with 3% and the latter with 5% by mass of quicklime. These mixtures have been analyzed at different curing times: At the addition of lime (0 d), and after a mellowing period of 7 and 28 d. The obtained results show that 3% of CaO is the percentage of quicklime able to modify the material (initial consumption of lime (ICL) and 5% of CaO is the percentage able to stabilize it (lime stabilization optimum (LSO). Finally, SEM images allowed for the monitoring of the process of reactions between the soil and lime during the mellowing period, while EDS analyses validated the XRD results in terms of chemical composition of the examined soil. For the examined natural clay, statistical analysis of the obtained EDS results identified a linear regression curve between the added quicklime and the after-treatment Ca content. The proposed approach could be adopted to calculate the content of calcium after the treatment and verify the in situ-added CaO during roadworks or at the end of them

La vinculación entre derechos humanos, memoria y universidad a través de dos proyectos : "Juicios Mendoza" y "Recuperar el exD2 como espacio de memoria"

El presente trabajo se propone compartir dos experiencias que vinculan universidad y DDHH. Nos referimos a los proyectos “Juicios Mendoza" y “Recuperar el ExD2 como espacio de memoria: estrategias de visibilización del sitio, elaboración y transmisión de su historia". Ambos proyectos son financiados por la UNCUYO, están integrados por representantes de los organismos de DDHH de Mendoza y por docentes y estudiantes de esta universidad, y se proponen “contribuir a la reconstrucción y difusión de los procesos dictatoriales en la historia reciente, así como a la promoción y formación en DDHH y ciudadanía activa". A continuación relataremos brevemente en qué consisten ambos proyectos, y algunas de las potencialidades que implica el trabajo colectivo entre estudiantes, docentes y los organismos de DDHH de Mendoza.Fil: Baigorria Bernal, Paula.Fil: Rodríguez Agüero, Laura Mercedes. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: López, Julia.Fil: D'Andrea, Sofía.Fil: Dolz, Carmen.Fil: Ilardo, Ivana

From Indicators to Policies: Open Sustainability Assessment in the Water and Sanitation Sector

A water and sanitation sustainability index (WASSI) was developed and estimated in four cities of the province of Salta, in northern Argentina. The index was built with nine descriptors and fifteen indicators that covered all essential aspects of the sustainability of local water and sanitation management systems. Only one of the cities studied obtained a sustainability value above the acceptability threshold adopted (50 of 100 points). Results indicate that the water company needs to address some environmental and social issues to enhance the sustainability of the systems studied. The WASSI was conceptually robust and operationally simple, and could be easily adapted to the case studies. The index can be followed and updated online on a web site specially developed for this project. This website could be useful to promote participatory processes, assist decision makers, and facilitate academic research. According to local stakeholders, a more open sustainability assessment based on sustainability indices and supported by virtual tools would be relevant and highly feasible. It would help decision makers improve the sustainability and transparency of water and sanitation management systems, and promote more sustainable water policies in the region and beyond.Fil: Iribarnegaray, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energia No Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energia No Convencional; ArgentinaFil: Gatto D'andrea, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energia No Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energia No Convencional; ArgentinaFil: Rodriguez Alvarez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energia No Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energia No Convencional; ArgentinaFil: Hernandez, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energia No Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energia No Convencional; ArgentinaFil: Brannstrom, Christian. Texas A&M University; Estados UnidosFil: Seghezzo, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energia No Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energia No Convencional; Argentin

Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting

In this study we report the effect of AZT on the whole protein expression profile both in the control and the AZT-treated K562 cells, evidenced by two-dimensional gel electrophoresis and peptide mass fingerprinting analysis. Two-dimensional gels computer digital image analysis showed two spots that appeared up-regulated in AZT-treated cells and one spot present only in the drug exposed samples. Upon extraction and analysis by peptide mass fingerprinting, the first two spots were identified as PDI-A3 and stathmin, while the third one was proved to be NDPK-A. Conversely, two protein spots were present only in the untreated K562 cells, and were identified as SOD1 and HSP-60, respectively

Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1

n/

Uso actual y potencial de aguas residuales domésticas (ARD) para irrigación en la provincia de Salta, Argentina

En este trabajo se presenta un relevamiento de las principales experiencias actuales de reutilización de aguas residuales domésticas (ARD) para irrigación en la provincia de Salta, Argentina. Se identificaron tres experiencias de reúso directo y cuatro experiencias de reúso indirecto de ARD para irrigación. Las mismas se localizan en inmediaciones a los sistemas de tratamiento de líquidos cloacales. La calidad microbiológica de los efluentes indica que ningún caso cumple con las directrices propuestas por la OMS para riego irrestricto y de áreas verdes. Se estima que el potencial de reúso con ARD en la provincia asciende a unas 3500 hectáreas, considerando cultivos de referencia según la localidad. Esta estimación debe ser complementada con estudios de factibilidad para cada caso en particular. Los resultados obtenidos representan un aporte para el reconocimiento y la validación de las aguas residuales como un recurso hídrico alternativo para la región.Fil: Salas Barboza, Ariela Griselda Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Gatto D'andrea, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Garces, V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Rodriguez Alvarez, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Liberal, Viviana Isabel. Universidad Nacional de Salta; ArgentinaFil: Paoli, H.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Seghezzo, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; Argentin