Strong evidence for an accelerating universe

A recent analysis of the Supernova Ia data claims a 'marginal' ($\sim3\sigma$) evidence for a cosmic acceleration. This result has been complemented with a non-accelerating $R_{h}=ct$ cosmology, which was presented as a valid alternative to the $\Lambda$CDM model. In this paper, we use the same analysis to show that a non-marginal evidence for acceleration is actually found. We compare the standard Friedmann models to the $R_{h}=ct$ cosmology by complementing SN Ia data with the Baryon Acoustic Oscillations, Gamma Ray Bursts and Observational Hubble datasets. We also study the power-law model which is a functional generalisation of $R_{h}=ct$. We find that the evidence for late-time acceleration is beyond refutable at a 4.56$\sigma$ confidence level from SN Ia data alone, and at an even stronger confidence level ($5.38\sigma$) from our joint analysis. Also, the non-accelerating $R_{h}=ct$ model fails to statistically compare with the $\Lambda$CDM having a $\Delta(\text{AIC})\sim30$

Self-attraction effect and correction on three absolute gravimeters

The perturbations of the gravitational field due to the mass distribution of an absolute gravimeter have been studied. The so called Self Attraction Effect (SAE) is crucial for the measurement accuracy, especially for the International Comparisons, and for the uncertainty budget evaluation. Three instruments have been analysed: MPG-2, FG5-238 and IMPG-02. The SAE has been calculated using a numerical method based on FEM simulation. The observed effect has been treated as an additional vertical gravity gradient. The correction (SAC) to be applied to the computed g value has been associated with the specific height level, where the measurement result is typically reported. The magnitude of the obtained corrections is of order 1E-8 m/s2.Comment: 14 pages, 8 figures, submitted to Metrologi

A promising new ELISA diagnostic test for cattle babesiosis based on Babesia bigemina Apical Membrane Antigen-1.

Babesiosis due to Babesia bigemina is a relevant tick‑borne disease, affecting cattle worldwide. Many surface proteins of the pathogen including the Apical Membrane Antigen 1 (AMA‑1) ‑ have been analysed for vaccine and diagnostic purposes. This study focused on B. bigemina AMA‑1 and on its use for the assessment of diagnostic tests. After bioinformatic analyses, AMA‑1 codifying region was amplified and cloned into an expression vector used to induce protein synthesis in Escherichia coli cells. AMA‑1 was purified by affinity chromatography and used to set up the best condition for an ELISA protocol. Bovine field sera positive to B. bigemina were used to evaluate the presence of anti‑AMA‑1 antibodies. In order to verify the assay specificity, sera positive to Babesia bovis or to the piroplasm Theileria annulata were also included. Significant differences were obtained between sera negative to both B. bigemina and B. bovis and samples positive to B. bigemina, to B. bovis or to both pathogens. No significant reaction was observed with T. annulata positive sera. The results showed that AMA‑1 protein is suitable to be used as antigen in diagnostic assays for babesiosis diagnosis in cattle, as it does not show any cross reaction with anti-T. annulata antibodies

Overload effects on fatigue cracks in ferritic-pearlitic ductile cast irons

Abstract Matrix microstructure (e.g., phases volume fraction, grains size and grain distribution) and graphite nodules morphology peculiarities (e.g., nodularity level, dimension, distribution etc.) strongly affect the mechanical behavior and damaging micromechanisms in Ductile Cast Irons (DCIs). Concerning the influence of the graphite nodules, it depends both on the matrix microstructure and the loading conditions (e.g., static, quasi-static or cyclic loadings). The influence of graphite nodules on the damaging micromechanisms is not univocally identified. Some authors proposed to consider the graphite nodules as voids embedded in a more or less ductile matrix; other authors recently proposed a more complex contribution of the graphite nodules, suggesting a mechanical properties gradient inside the graphite nodules, with the graphite elements – matrix debonding as only one of the possible damaging micromechanisms. In this work, three different ferritic-pearlitic DCIs were investigated, focusing the damaging micromechanisms due to overloads applied on fatigue cracked Compact Type specimens. Scanning Electron Microscope (SEM) and Digital Microscope (DM) observations were performed on the lateral surfaces of the overloaded specimens following a step by step procedure: SEM observations were mainly focused on the damaging mechanisms in graphite nodules; DM observations were mainly focused on the damaging mechanisms in the ferritic-pearlitic matrix

Process assessment of renewable-based acrylic acid production from glycerol valorisation

The continuous growth of biodiesel production via transesterification is leading to an increase in the generation and availability of the by-product glycerol. In this study, a glycerol-based process for the production of acrylic acid has been designed and simulated. The valorisation of glycerol route includes a two-step conversion process where glycerol is first dehydrated to acrolein and acrolein is selectively oxidised to acrylic acid. This renewable-based process is then compared in terms of heat integration and techno-economic performance to the traditional petrochemical route from propylene from a techno-economic and environmental point of view. The study includes the detailed design of the separation train in which azeotropic distillation is also assessed along with the sensitivity analysis of the most relevant variables of the process. Using a production basis of approximately 10,250 kg h−1 of acrylic acid (purity>99.5 wt%), results show that the glycerol route generates 37.3% less CO2 emissions than the propylene-based. From the heat integration analysis, slightly lower heating (96.6%) but higher cooling (32.4%) energy savings can be attained in the glycerol route as opposed to heating (100%) and cooling (21.6%) energy savings available in the propylene-based route. In terms of economics, the glycerol-based route has a lower capital expenditure (£74.0 million) and operating expenditure (£171.4 million yr−1) compared to the propylene route (£91.3 million and £180.2 million yr−1, respectively). Nevertheless, considering the use of raw material and its cost, the glycerol route is more demanding (1.96 kg h−1 of pure glycerol per kg h−1 of acrylic acid amounting to £138.6 million yr−1) than the propylene route (0.92 kg h−1 of propylene per kg h−1 of acrylic acid at £117.2 million yr−1)

Crack path and damage in a CuZnAl SMA

Abstract: Pseudo-elastic (PE) materials are an important class of metallic alloy which exhibit unique features with respect to common engineering metals. In particular, due to these properties PEs are able to recover their original shape after high values of mechanical deformations, by removing the mechanical load (PE). From the microstructural point of view shape memory and pseudo-elastic effects are due to a reversible solid state microstructural diffusionless transitions from austenite to martensite, which can be activated by mechanical and/or thermal loads. Copper-based shape memory alloys are preferred for their good memory properties and low cost of production. In this work the main crack initiation and its propagation in a tensile test is analyzed in order to evaluate crack path and its behavior at low and at high values of deformation. Results are also associated both to grains boundary chemical properties and to X-ray diffraction, in order to correlate structural transition involved in an Cu-Zn-Al alloy characterized by a PE behavior

Histamine plasma levels and elimination diet in chronic idiopathic urticaria

Abstract: Objective: The aim of this study was to evaluate the effects of an oligoantigenic and histamine-free diet on patients affected with chronic idiopathic urticaria (CIU). Design: Ten patients with chronic idiopathic urticaria were prescribed an oligoantigenic and histamine-free diet for 21 days, followed by serial and controlled reintroduction of foods during a further 70 days. Modification in clinical illness as well as histamine plasma levels, post-heparin plasma diamine oxidase (DAO) and intestinal permeability were evaluated. Results: The oligoantigenic and histamine-free diet induced a significant improvement of symptoms (P < 0.05). Moreover, CIU patients on free diet showed higher histamine plasma levels (P < 0.05 vs post-diet and vs controls) that fell to control levels during the oligoantigenic and histamine-free diet. Post-heparin plasma diamine oxidase values were slightly reduced and were unchanged during the diet as well as intestinal permeability, which was always normal in all patients. Conclusions: These data suggest that histamine plays a major role in chronic idiopathic urticaria. The finding of normal intestinal permeability suggests that a morphological damage of intestinal mucosa should be excluded in these patients. However, the presence of low levels of post-heparin plasma diamine oxidase may indicate a subclinical impairment of small bowel enterocyte function that could induce a higher sensitivity to histamine-rich or histamine-producing food

Continuum and discrete models for structures including (quasi-) inextensible elasticae with a view to the design and modeling of composite reinforcements

Inspired by some composite fiber reinforcements used in aeronautical engineering and by the need of conceiving new metamaterials, some discrete models including (quasi-) inextensible elasticae are considered. A class of continuum models approximately describing the macroscopic mechanical behavior of introduced structures is then heuristically proposed. Some of these continuum models can be regarded as a special kind of second-gradient elastic media, in which the higher-gradient elasticity is conferred by the flexural stiffnesses of elasticae constituting the microscopic lattice. The discrete models are studied by means of suitably tailored numerical codes designed to avoid numerical instabilities and locking and a comparison of discrete versus continuum models is attempted. The obtained results show that the theory of generalized continua may be useful in some engineering applications and it plays a relevant role in the mechanics of woven composites. The introduced discrete and continuum models are used to describe the so-called bias extension test on woven fabrics and it is shown that a good choice to correctly reproduce the targeted phenomenology is to use a second gradient continuum theory. However, as discussed throughout the paper, in the context of rigorous micro-macro identification procedures there still remain many open problems to be solved, especially when dealing with systems subjected to particular constraints, such as inextensibility. © 2014 Elsevier Ltd

Measuring emptiness: Validation of the Italian version of the Subjective Emptiness Scale in clinical and non-clinical populations

Background: Although a feeling of emptiness is listed only as a symptom of the DSM-5 borderline personality disorder, it is commonly encountered in other disorders. The aim of this study was to validate the Italian version of the Subjective Emptiness Scale (SES-I), a 7-item self-report instrument assessing the feeling of emptiness. Methods: Participants in one clinical group (n = 63) and one non-clinical group (n = 48) completed the SES-I along with several other instruments. A principal component analysis was used to analyze the structure of the SES-I and Cronbach's alpha and Rho's Spearman were used to establish aspects of reliability and validity, respectively. Results: The SES-I has a unidimensional structure reflecting the core feature of the feeling of emptiness. It showed an excellent internal consistency (a = 0.92) and convergent validity, as demonstrated by significant correlations with scores on the Beck Depression Inventory – II and conceptually related scales and subscales of the Millon Clinical Multiaxial Inventory – III and Personality Inventory for DSM-5. Divergent validity was also demonstrated for the SES-I. SES-I scores in the clinical group were significantly higher than in the non-clinical group. A significant relationship was not found between the feeling of emptiness and self-harming behavior, impulsivity and acting-out. Limitations: A small sample size, several significant differences between the clinical and non-clinical groups and diagnostic heterogeneity in the clinical group limit generalizability of the study. Conclusion: The SES-I is a valid and reliable instrument, which should improve assessment of the feeling of emptiness and help clinicians better understand this complex phenomenon