WYBRANE PROBLEMY WARTOŚCIOWANIA I KLASYFIKACJI BUDOWLI ZABYTKOWYCH Z WYKORZYSTANIEM ZBIORÓW PRZYBLIŻONYCH

The paper presents the problems associated with multicriteria evaluation of historic buildings. The capabilities of modeling the monuments in order to use the Rough Sets approach for their evaluation were presented. The problems of selection criteria for the evaluation and taking into account the structure of the object, as well as the problem of discretization and its impact on the generating of the rules were discussed.W artykule zaprezentowano problemy związane z wielokryterialną oceną budowli zabytkowych. Przedstawione zostały możliwości modelowania obiektu zabytkowego w celu wykorzystania podejścia Zbiorów Przybliżonych dla ich wartościowania. Omówiono problemy doboru kryteriów oceny oraz uwzględnienia struktury obiektu, jak również problem dyskretyzacji i jego wpływ na generowanie reguł

Peroxiredoxin-5 is a negative survival predictor in ovarian cancer

Objectives: Peroxiredoxins (PRDXs) constitute a family of antioxidant enzymes which are also involved in the process of carcinogenesis. They are composed of six identified isoforms (PRDX-1-6) and are supposed to play different roles in tumor progression, depending on type of cancer and member of the PRDX family. The aim of the study was to assess the prog- nostic value of PRDXs in ovarian cancer. Material and methods: a dataset of patients with ovarian cancer from The Cancer Genome Atlas was analyzed. Expression of PRDX-1 to 6 mRNA was evaluated in 260 samples. The prognostic value of PRDXs was assessed using the Cox regression model which included the following clinical and pathological data: age, clinical stage, tumor grade, and residual disease. Results: Within the PRDXs family, only higher expression of PRDX-5 was associated with worse overall survival both, in unselected patients and > 50-year-olds. PRDX-5 expression and residual disease were independent negative prognostic factors of patient survival. Conclusions: PRDX-5 is a negative predictor of survival in ovarian cancer.

The influence of the keywords selection method on the effectiveness of the web pages classification using the boosting algorithm

The paper concerns the issues of web pages analysis process. The classification is performed based on the analysis of the structure as well content of pages. Various characteristics are taken into account including inter alia, structural, visual, text, web and links features. During the construction of classifiers the AdaBoost algorithm was applied. This paper focuses on the impact of keyword selection methods on the effectiveness of the classification process

Application of Levonorgestrel-releasing intrauterine system in early pregnancy: a case report

Intrauterine device is a popular, cost-effective method of contraception known worldwide. It is extremely effective, with pregnancy rates comparable to tubal ligation (5-year cumulative rate varying from 0.5 to 1.1). LNG-IUS increases in popularity and may be used as the method of choice for adults because it offers non-contraceptive benefits: slight menstrual bleeding, decreased number of incidents of dysmenorrhea, and reduced pain associated with endometriosis. The levonorgestrel-releasing intrauterine system (LNG-IUS) provides a release rate of 20 μg/24h of levonorgestrel. The hormone released from the intrauterine device causes some systemic changes, however local effects, such as glandular atrophy and stromal decidualization, in addition to foreign body reaction, are dominant. According to the Food and Drug Administration regulations, category X was assigned to LNG. The use of the product is contraindicated in women who are or may become pregnant. We report a case of a 30-year old woman who has already been pregnant before the insertion of a levonorgestrel –releasing intrauterine system (LNG-IUS). The patient was lactating after the previous pregnancy, the first menstruation had not appeared yet. The patient planned to have the IUD inserted but she missed her appointed visits twice. The third visit took place 8 weeks postpartum. During that visit, the doctor asked her about the possibility of being pregnant, but the patient denied. The gynecologist inserted the intrauterine device and performed transvaginal ultrasound examination. The location of LNG-IUS was proper and there was no gestation sac in the uterine cavity. After the next six weeks, transvaginal ultrasonography and manual examination showed an intrauterine pregnancy at 8 weeks of gestation. The intrauterine device was not detectable in the uterine cavity by ultrasound, and the IUD strings were not visualized in the vagina. It was impossible to remove the device without causing miscarriage. Other risks during pregnancy were connected with potential masculinisation of the fetus by levonorgestrel, premature delivery, and preterm rupture of the membranes. The pregnancy progressed normally, and the delivery was uncomplicated. A female infant was born without congenital abnormalities. The pediatrician did not find any indices of infection. The IUD was found in fetal membranes. The postpartum recovery was uneventful. This case report demonstrates that a healthy infant can be delivered at term with an IUS in situ, probably without causing any abnormalities. Due to that fact that adverse effects of fetal exposure to the LNG-IUS have not been yet established, the exclusion of pregnancy before IUD insertion is strictly indicated