Beyond the pill: New medication delivery options for ADHD

Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules. This is especially true for attention-deficit/hyperactivity disorder (ADHD), which is one of the most common chronic pediatric conditions and often involves children with a variety of overlapping physical, psychological, or neurodevelopmental disorders. A special challenge for developing alternative dosage forms for ADHD treatment is the incorporation of a once-daily long-acting formulation. Traditional ADHD medication formulations have been limited, and issues surrounding prescribed dosing regimens—including poor medication adherence, difficulty swallowing, and the lack of dosing titration options—persist in ADHD treatment. In other disease areas, the development of alternative formulations has provided options for patients who have issues with consuming solid dosage forms, particularly children and individuals with developmental disorders. In the light of these new developments, several alternative formulations for ADHD medications are under development or have recently become available. This article reviews the various strategies for developing alternative dosage forms in other disease areas and discusses the application of these strategies in ADHD treatment. Alternative dosage forms may increase medication adherence, compliance, and patient preference and, therefore, improve the overall treatment for ADHD.</jats:p

Discrimination of unique biological communities in the Mississippi lignite belt

Small scale hardcopy LANDSAT prints were manually interpreted and color infrared aerial photography was obtained in an effort to identify and map large contiguous areas of old growth hardwood stands within Mississippi's lignite belt which do not exhibit signs of recent disturbance by agriculture, grazing, timber harvesting, fire, or any natural catastrophe, and which may, therefore, contain unique or historical ecological habitat types. An information system using land cover classes derived from digital LANDSAT data and containing information on geology, hydrology, soils, and cultural activities was developed. Using computer-assisted land cover classifications, all hardwood remnants in the study area which are subject to possible disturbance from surface mining were determined. Twelve rare plants were also identified by botanists

The information content of gravitational wave harmonics in compact binary inspiral

The nonlinear aspect of gravitational wave generation that produces power at harmonics of the orbital frequency, above the fundamental quadrupole frequency, is examined to see what information about the source is contained in these higher harmonics. We use an order (4/2) post-Newtonian expansion of the gravitational wave waveform of a binary system to model the signal seen in a spaceborne gravitational wave detector such as the proposed LISA detector. Covariance studies are then performed to determine the ultimate accuracy to be expected when the parameters of the source are fit to the received signal. We find three areas where the higher harmonics contribute crucial information that breaks degeneracies in the model and allows otherwise badly-correlated parameters to be separated and determined. First, we find that the position of a coalescing massive black hole binary in an ecliptic plane detector, such as OMEGA, is well-determined with the help of these harmonics. Second, we find that the individual masses of the stars in a chirping neutron star binary can be separated because of the mass dependence of the harmonic contributions to the wave. Finally, we note that supermassive black hole binaries, whose frequencies are too low to be seen in the detector sensitivity window for long, may still have their masses, distances, and positions determined since the information content of the higher harmonics compensates for the information lost when the orbit-induced modulation of the signal does not last long enough to be apparent in the data.Comment: 13 pages, 5 figure

The Angular Resolution of Space-Based Gravitational Wave Detectors

Proposed space-based gravitational wave antennas involve satellites arrayed either in an equilateral triangle around the earth in the ecliptic plane (the ecliptic-plane option) or in an equilateral triangle orbiting the sun in such a way that the plane of the triangle is tilted at 60 degrees relative to the ecliptic (the precessing-plane option). In this paper, we explore the angular resolution of these two classes of detectors for two kinds of sources (essentially monochromatic compact binaries and coalescing massive-black-hole binaries) using time-domain expressions for the gravitational waveform that are accurate to 4/2 PN order. Our results display an interesting effect not previously reported in the literature, and underline the importance of including the higher-order PN terms in the waveform when predicting the angular resolution of ecliptic-plane detector arrays.Comment: 13 pages, 6 figures, submitted to Phys Rev D. The current version corrects an error in our original paper and adds some clarifying language. The error also required correction of the graphs now shown in Figures 3 through

Regularization of the second-order gravitational perturbations produced by a compact object

The equations for the second-order gravitational perturbations produced by a compact-object have highly singular source terms at the point particle limit. At this limit the standard retarded solutions to these equations are ill-defined. Here we construct well-defined and physically meaningful solutions to these equations. These solutions are important for practical calculations: the planned gravitational-wave detector LISA requires preparation of waveform templates for the potential gravitational-waves. Construction of templates with desired accuracy for extreme mass ratio binaries, in which a compact-object inspirals towards a supermassive black-hole, requires calculation of the second-order gravitational perturbations produced by the compact-object.Comment: 12 pages, discussion expanded, to be published in Phys. Rev. D Rapid Communicatio

Construction of the second-order gravitational perturbations produced by a compact object

Accurate calculation of the gradual inspiral motion in an extreme mass-ratio binary system, in which a compact-object inspirals towards a supermassive black-hole requires calculation of the interaction between the compact-object and the gravitational perturbations that it induces. These metric perturbations satisfy linear partial differential equations on a curved background spacetime induced by the supermassive black-hole. At the point particle limit the second-order perturbations equations have source terms that diverge as $r^{-4}$, where $r$ is the distance from the particle. This singular behavior renders the standard retarded solutions of these equations ill-defined. Here we resolve this problem and construct well-defined and physically meaningful solutions to these equations. We recently presented an outline of this resolution [E. Rosenthal, Phys. Rev. D 72, 121503 (2005)]. Here we provide the full details of this analysis. These second-order solutions are important for practical calculations: the planned gravitational-wave detector LISA requires preparation of waveform templates for the expected gravitational-waves. Construction of templates with desired accuracy for extreme mass-ratio binaries requires accurate calculation of the inspiral motion including the interaction with the second-order gravitational perturbations.Comment: 30 page