46 research outputs found
bantam Is Required for Optic Lobe Development and Glial Cell Proliferation
microRNAs (miRNAs) are small, conserved, non-coding RNAs that contribute to the control of many different cellular processes, including cell fate specification and growth control. Drosophila bantam, a conserved miRNA, is involved in several functions, such as stimulating proliferation and inhibiting apoptosis in the wing disc. Here, we reported the detailed expression pattern of bantam in the developing optic lobe, and demonstrated a new, essential role in promoting proliferation of mitotic cells in the optic lobe, including stem cells and differentiated glial cells. Changes in bantam levels autonomously affected glial cell number and distribution, and non-autonomously affected photoreceptor neuron axon projection patterns. Furthermore, we showed that bantam promotes the proliferation of mitotically active glial cells and affects their distribution, largely through down regulation of the T-box transcription factor, optomotor-blind (omb, Flybase, bifid). Expression of omb can rescue the bantam phenotype, and restore the normal glial cell number and proper glial cell positioning in most Drosophila brains. These results suggest that bantam is critical for maintaining the stem cell pools in the outer proliferation center and glial precursor cell regions of the optic lobe, and that its expression in glial cells is crucial for their proliferation and distribution
Understanding the growth in outdoor recreation participation: an opportunity for sport development in the United Kingdom
© 2018, © 2019 Informa UK Limited, trading as Taylor & Francis Group. This paper examines the growth in importance and scale of the outdoor recreation sector in the United Kingdom. It establishes a five-component model to help understand the growth in this sub-sector of the wider sport and physical activity industry. The paper is based on a narrative literature review of the importance of outdoor recreation and also sets the position of the sector in terms of sport policy in the UK. From determining the factors that are underpinning the growing importance of the sector the article goes on to establish implications for policy and practice in sport policy and development in the UK and beyond. It seeks to establish lesson learning between industry and academia that has underpinned the evolution of outdoor recreation policy development in recent years. Furthermore, it establishes future research agendas and directions for those working in outdoor recreation and physical activity spaces and places
Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping
Secondary PE teacher candidates’ perceptions and reactions on the experiences of educational service activities
Farmer perspectives on benefits of and barriers to extended crop rotations in Iowa, USA
Abstract The highly specialized maize (Zea mays L.) and soybean [Glycine max (L.) Merr.] production system that dominates midwestern U.S. agriculture has led to widespread on‐farm and off‐farm degradation of and damage to natural resources. The practice of extending maize–soybean rotations with small grains and forages has great potential to balance production and environmental goals, but adoption of these practices is low. Because little is known about farmers’ perspectives on extended rotations, we conducted social survey research with Iowa farmers to address this knowledge gap. Results show that farmers understand the potential benefits of extended rotations using small grains, but they perceive major barriers to use. The highest‐rated barriers were structural, such as lack of markets. Structural barriers cannot be easily addressed by individual farmers, indicating that efforts to address negative impacts of specialized commodity production through extended rotations with small grains will require transformative changes in agri‐food policies, programs, and ultimately markets