Multi-wavelength SPAD photoplethysmography for cardio-respiratory monitoring

There is a growing interest in photoplethysmography (PPG) for the continuous monitoring of cardio-respiratory signals by portable instrumentation aimed at the early diagnosis of cardiovascular diseases. In this context, it is conceivable that PPG sensors working at different wavelengths simultaneously can optimize the identification of apneas and the quantification of the associated heart-rate changes or other parameters that depend on the PPG shape (e.g., systematic vascular resistance and pressure), when evaluating the severity of breathing disorders during sleep and in general for health monitoring. Therefore, the objective of this work is to present a novel pulse oximeter that provides synchronous data logging related to three light wavelengths (green, red, and infrared) in transmission mode to optimize both heart rate measurements and a reliable and continuous assessment of oxygen saturation. The transmission mode is considered more robust over motion artifacts than reflection mode, but current pulse oximeters cannot employ green light in transmission mode due to the high absorbance of body tissues at this wavelength. For this reason, our device is based on a Single-Photon Avalanche Diode (SPAD) with very short deadtime (less than 1 ns) to have, at the same time, the single photon sensitivity and high-count rate that allows acquiring all the wavelengths of interest on the same site and in transmission mode. Previous studies have shown that SPAD cameras can be used for measuring the heart rate through remote PPG, but oxygen saturation and heart-rate measures through contact SPAD-based PPG sensors have never been addressed so far. The results of the preliminary validation on six healthy volunteers reflect the expected physiological phenomena, providing rms errors in the Inter Beat Interval estimation smaller than 70 ms (with green light) and a maximum error in the oxygen saturation smaller than 1% during the apneas. Our prototype demonstrates the reliability of SPAD-based devices for continuous long-term monitoring of cardio-respiratory variables as an alternative to photodiodes especially when minimal area and optical power are required

Non-Line-of-Sight Tracking and Mapping with an Active Corner Camera

The ability to form non-line-of-sight (NLOS) images of changing scenes could be transformative in a variety of fields, including search and rescue, autonomous vehicle navigation, and reconnaissance. Most existing active NLOS methods illuminate the hidden scene using a pulsed laser directed at a relay surface and collect time-resolved measurements of returning light. The prevailing approaches include raster scanning of a rectangular grid on a vertical wall opposite the volume of interest to generate a collection of confocal measurements. These are inherently limited by the need for laser scanning. Methods that avoid laser scanning track the moving parts of the hidden scene as one or two point targets. In this work, based on more complete optical response modeling yet still without multiple illumination positions, we demonstrate accurate reconstructions of objects in motion and a 'map' of the stationary scenery behind them. The ability to count, localize, and characterize the sizes of hidden objects in motion, combined with mapping of the stationary hidden scene, could greatly improve indoor situational awareness in a variety of applications

Gated SPAD Arrays for Single-Photon Time-Resolved Imaging and Spectroscopy

In this paper, we present the architecture and the experimental characterization of an improved version of a previously developed 32 × 32 Single Photon Avalanche Diodes (SPADs) and Time to Digital Converters (TDCs) array, and two new arrays (with 8 × 8 and 128 × 1 pixels) with the additional capability of actively gating the detectors with sub-nanosecond rise time. The arrays include high performance SPADs (0.04 cps/μm2, 50% peak PDE) and provide down to 410 ps Full-Width at Half-Maximum (FWHM) single shot precision and excellent linearity. We developed a camera to exploit these imagers in time-resolved, single-photon applications

Three-wavelength SPAD-based photoplethysmography

Continuous and real-time monitoring of cardiorespiratory signals by portable and accurate instrumentation is very important for the early diagnosis of cardiovascular diseases. We aim to present a novel photoplethysmography device to assess changes in blood oxygen saturation and beat-bybeat pulse waves of finger blood volumes not affected by possibly occurring variations in oxygen saturation. For this purpose, our device works at three light wavelengths simultaneously and is based on a Single-Photon Avalanche Diode to evaluate the feasibility of using this technology in contact photoplethysmography. Our preliminary validation shows that the device is robust against movement artifacts and provides measures that reflect the physiological cardiorespiratory adaptations to the Valsalva maneuver, suggesting its overall reliability and possible use in cardiovascular monitoring