17 research outputs found
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Miniature Chemical Sensor combining Molecular Recognition with Evanescent Wave Cavity Ring-Down Spectroscopy
To address the chemical sensing needs of DOE, a new class of chemical sensors is being developed that enables qualitative and quantitative, remote, real-time, optical diagnostics of chemical species in hazardous gas, liquid, and semi-solid phases by employing evanescent wave cavity ring-down spectroscopy (EW-CRDS). The feasibility and sensitivity of EW-CRDS was demonstrated previously under Project No.60231. The objective of this project is to enhance the selectivity and range of application of EW-CRDS. Selectivity is achieved spectroscopically by using vibrational overtones in the near infrared and chemically by using modified surfaces to encourage selective adsorption of analyte while preventing non-selective adsorption. The range of application is expanded by extending EW-CRDS to liquids and by combining EW-CRDS with the unique optical properties of nanoparticles
Recommended from our members
Miniature Chemical Sensor Combining Molecular Recognition with Evanescent Wave Cavity Ring-Down Spectroscopy
To address the chemical sensing needs of DOE, a new class of chemical sensors is being developed that enables qualitative and quantitative, remote, real-time, optical diagnostics of chemical species in hazardous gas, liquid, and semi-solid phases by employing evanescent wave cavity ringdown spectroscopy (EW-CRDS). The sensitivity of EW-CRDS was demonstrated previously under Project No.60231. The objective of this project is to enhance the range of application and selectivity of the technique by combining EW-CRDS with refractive-index-sensitive nanoparticle optics, molecular recognition (MR) chemistry, and by utilizing the polarization-dependence of EW-CRDS. Research Progress and Implication
Recommended from our members
Miniature Chemical Sensor combining Molecular Recognition with Evanescent Wave Cavity Ring-Down Spectroscopy
To address the chemical sensing needs of DOE, a new class of chemical sensors is being developed that enables qualitative and quantitative, remote, real-time, optical diagnostics of chemical species in hazardous gas, liquid, and semi-solid phases by employing evanescent wave cavity ring-down spectroscopy (EW-CRDS). The feasibility and sensitivity of EW-CRDS was demonstrated previously under Project No.60231. The objective of this project is to enhance the selectivity and domain of application of EW-CRDS. Selectivity is enhanced by using molecular recognition (MR) chemistry and polarized ''fingerprint'' near-IR spectroscopy, while the domain of application is expanded by combining EW-CRDS with the unique optical properties of nanoparticles and by extending the technique to liquids
Self-Assembled Monolayers of Methyl 1-Thiahexa(ethylene oxide) for the Inhibition of Protein Adsorption
Assessing the Molecular Structure of Alkanethiol Monolayers in Hybrid Bilayer Membranes with Vibrational Spectroscopies
Submultiple Data Collection to Explore Spectroscopic Instrument Instabilities Shows that Much of the “Noise” is not Stochastic
As
has long been understood, the noise on a spectrometric signal
can be reduced by averaging over time, and the averaged noise is expected
to decrease as <i>t</i><sup>1/2</sup>, the square root of
the data collection time. However, with contemporary capability for
fast data collection and storage, we can retain and access a great
deal more information about a signal train than just its average over
time. During the same collection time, we can record the signal averaged
over much shorter, equal, fixed periods. This is, then, the set of
signals over submultiples of the total collection time. With a sufficiently
large set of submultiples, the distribution of the signal’s
fluctuations over the submultiple periods of the data stream can be
acquired at each wavelength (or frequency). From the autocorrelations
of submultiple sets, we find only some fraction of these fluctuations
consist of stochastic noise. Part of the fluctuations are what we
call “fast drift”, which is defined as drift over a
time shorter than the complete measurement period of the average spectrum.
In effect, what is usually assumed to be stochastic noise has a significant
component of fast drift due to changes of conditions in the spectroscopic
system. In addition, we show that the extreme values of the fluctuation
of the signals are usually not balanced (equal magnitudes, equal probabilities)
on either side of the mean or median without an inconveniently long
measurement time; the data is almost inevitably biased. In other words,
the unbalanced data is collected in an unbalanced manner around the
mean, and so the median provides a better measure of the true spectrum.
As is shown here, by using the medians of these distributions, the
signal-to-noise of the spectrum can be increased and sampling bias
reduced. The effect of this submultiple median data treatment is demonstrated
for infrared, circular dichroism, and Raman spectrometry
Stray Light Correction in the Optical Spectroscopy of Crystals
It has long been known in spectroscopy that light not passing through a sample, but reaching the detector (i.e., stray light), results in a distortion of the spectrum known as absorption flattening. In spectroscopy with crystals, one must either include such stray light or take steps to exclude it. In the former case, the derived spectra are not accurate. In the latter case, a significant amount of the crystal must be masked off and excluded. In this paper, we describe a method that allows use of the entire crystal by correcting the distorted spectrum