Description of two measles outbreaks in the Lazio Region, Italy (2006-2007). Importance of pockets of low vaccine coverage in sustaining the infection

<p>Abstract</p> <p>Background</p> <p>Despite the launch of the national plan for measles elimination, in Italy, immunization coverage remains suboptimal and outbreaks continue to occur. Two measles outbreaks, occurred in Lazio region during 2006-2007, were investigated to identify sources of infection, transmission routes, and assess operational implications for elimination of the disease.</p> <p>Methods</p> <p>Data were obtained from several sources, the routine infectious diseases surveillance system, field epidemiological investigations, and molecular genotyping of virus by the national reference laboratory.</p> <p>Results</p> <p>Overall 449 cases were reported, sustained by two different stereotypes overlapping for few months. Serotype D4 was likely imported from Romania by a Roma/Sinti family and subsequently spread to the rest of the population. Serotype B3 was responsible for the second outbreak which started in a secondary school. Pockets of low vaccine coverage individuals (Roma/Sinti communities, high school students) facilitated the reintroduction of serotypes not endemic in Italy and facilitated the measles infection to spread.</p> <p>Conclusions</p> <p>Communities with low vaccine coverage represent a more serious public health threat than do sporadic susceptible individuals. The successful elimination of measles will require additional efforts to immunize low vaccine coverage population groups, including hard-to-reach individuals, adolescents, and young adults. An enhanced surveillance systems, which includes viral genotyping to document chains of transmission, is an essential tool for evaluating strategy to control and eliminate measles</p

Improving skills and utilization of Community Health Volunteers in Nepal

The study analyses the effects of a Nutrition Education Intervention (NEI), specifically designed to reduce vitamin A deficiency, on skills and utilization of Community Health Volunteers (CHVs) in rural Nepal. The intervention, which included preventive and curative activities, was carried out through the existing Primary Health Care (PHC) structure, utilizing CHVs trained by the Ministry of Health and already working in the villages. At the end of two years implementation, the CHVs associated with the NEI showed an improved ability to detect and treat a range of common diseases (diarrhoea, night blindness, malnutrition and acute respiratory infections) as compared with the CHVs not associated with the intervention program. Community utilization of CHVs increased significantly while the use of traditional healers and consultations at private pharmacies decreased. The utilization of health posts and referral to hospitals remained constant. Coverage for all activities carried out by the CHVs was higher among the population within the NEI area. The intervention did not utilize cash incentives. Its operational input consisted mainly of more frequent training, added supervision and increased and regular drug supply. The inclusion of curative activities among the CHVs' responsibilities seems to be a key factor in increasing motivation of volunteers and their acceptance within the community. This study indicated some possible adjustments to improve productivity and utilization of health volunteers in rural communities of Nepal, with a positive return for all PHC activities.Nepal Community Health Volunteer primary health care nutrition education

Incidence of bacterial meningitis (2001–2005) in Lazio, Italy: the results of a integrated surveillance system

Abstract Background Monitoring the incidence of bacterial meningitis is important to plan and evaluate preventive polices. The study's aim was to estimate the incidence of bacterial meningitis by aetiological agent in the period 2001–2005, in Lazio Italy (5.3 mln inhabitants). Methods Data collected from four sources – hospital surveillance of bacterial meningitis, laboratory information system, the mandatory infectious diseases notifications, and hospital information system – were combined into a single archive. Results 944 cases were reported, 89% were classified as community acquired. S. pneumoniae was the most frequent aetiological agent in Lazio, followed by N. meningitis. Incidence of H. influenzae decreased during the period. 17% of the cases had an unknown aetiology and 13% unspecified bacteria. The overall incidence was 3.7/100,000. Children under 1 year were most affected (50.3/100.000), followed by 1–4 year olds (12.5/100,000). The percentage of meningitis due to aetiological agents included in the vaccine targets, not considering age, is 31%. Streptococcus spp. was the primary cause of meningitis in the first three months of life. The capture-recapture model estimated underreporting at 17.2% of the overall incidence. Conclusion Vaccine policies should be planned and monitored based on these results. The integrated surveillance system allowed us to observe a drop in H. influenzae b meningitis incidence consequent to the implementation of a mass vaccination of newborns.</p

Very high fascioliasis intensities in schoolchildren from nile delta governorates, egypt: The old world highest burdens found in lowlands

Quantitative coprological analyses of children were performed in Alexandria and Behera governorates, Egypt, to ascertain whether individual intensities in the Nile Delta lowlands reach high levels as those known in hyperendemic highland areas of Latin America. Analyses focused on subjects presenting intensities higher than 400 eggs per gram of faeces (epg), the high burden cut-off according to WHO classification. A total of 96 children were found to shed between 408 and 2304 epg, with arithmetic and geometric means of 699.5 and 629.07 epg, respectively. Intensities found are the highest hitherto recorded in Egypt, and also in the whole Old World. A total of 38 (39.6%) were males and 58 (60.4%) were females, with high intensities according to gender following a negative binomial distribution. The high burden distribution shows a peak in the 7–10 year-old children group, more precocious in females than males. Results showed high burdens in winter to be remarkably higher than those known in summer. The fascioliasis scenario in Egyptian lowlands shows similarities to highlands of Bolivia and Peru. Diagnostic methods, pathogenicity and morbidity in high burdens should be considered. The need for an appropriate quantitative assessment of heavy infected children to avoid post-treatment colic episodes is highlighted.Fil: Periago, Maria Victoria. Fundación Mundo Sano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Valencia; EspañaFil: Adela Valero, M.. Universidad de Valencia; EspañaFil: Artigas, Patricio. Universidad de Valencia; EspañaFil: Agramunt, Verónica H.. Universidad de Valencia; EspañaFil: Bargues, M. Dolores. Universidad de Valencia; EspañaFil: Curtale, Filippo. Istituto Nazionale Per la Promozione Della Salute; ItaliaFil: Mas-Coma, Santiago. Universidad de Valencia; Españ