Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

BACKGROUND: Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique. The aim of this study was to analytically validate the applicability of I-FISH in assessing 9p deletion in ccRCC and to clinically assess its long-term prognostic impact following surgical excision of ccRCC. METHODS: Tissue microarrays were constructed from 108 renal cell carcinoma (RCC) tumour paraffin blocks. Interphase fluorescent in situ hybridisation analysis was undertaken based on preset criteria by two independent observers to assess interobserver variability. 9p status in ccRCC tumours was determined and correlated to clinicopathological variables, recurrence-free survival and disease-specific survival. RESULTS: There were 80 ccRCCs with valid 9p scoring and a median follow-up of 95 months. Kappa statistic for interobserver variability was 0.71 (good agreement). 9p deletion was detected in 44% of ccRCCs. 9p loss was associated with higher stage, larger tumours, necrosis, microvascular and renal vein invasion, and higher SSIGN (stage, size, grade and necrosis) score. Patients with 9p-deleted ccRCC were at a higher risk of recurrence (P=0.008) and RCC-specific mortality (P=0.001). On multivariate analysis, 9p deletion was an independent predictor of recurrence (hazard ratio 4.323; P=0.021) and RCC-specific mortality (hazard ratio 4.603; P=0.007). The predictive accuracy of SSIGN score improved from 87.7% to 93.1% by integrating 9p status to the model (P=0.001). CONCLUSIONS: Loss of 9p is associated with aggressive ccRCC and worse prognosis in patients following surgery. Our findings independently confirm the findings of previous reports relying on I-FISH to detect 9p (CDKN2A) deletion

Design study of Low Loss Single-Mode Hollow Core Photonic Crystal Terahertz Waveguide with Support Bridges

We present a design study of an all-polymer low loss single-mode hollow-core photonic crystal (HCPC) terahertz (THz) waveguide with dielectric bridges used as mechanical supports. By exploiting a modal-filtering effect and Brewster phenomenon, we maximize the loss discrimination between the fundamental and other higher order modes resulting in an effectively single-mode operation, though the HCPC THz waveguide is ostensibly multi-mode. Owing to the use of support bridges, which increase the propagation loss, the non-ideal HCPC THz waveguide has higher loss than an ideal one. Nonetheless, the propagation loss of the fundamental HE11 mode can still be minimized, to lower than 5 dB/m over the frequency range from 0.75 to 1.1 THz. In addition, the group velocity dispersion of the HE11 mode is less than -0.5 ps/THz/cm

Participation and power dynamics between international non-governmental organisations and local partners: A rural water case study in Indonesia

© 2019 Water Alternatives Association. Community-Based Management (CBM) is an important part of Indonesia's goal of universal access to water. However, approaches to CBM tend to neglect the impact of power relationships between community-based organisations (CBOs) and their external donor partners on CBO management capacity. This paper explores the power dynamics between a CBO and their donor partner, the international NGO Engineers Without Borders Australia (EWB), in a rural water supply project in Tenganan, Indonesia. A diffracted power frame was used to analyse the response of CBO power to EWB's participatory approach. The approach was sensitised to power, gave primacy to the CBO's vision, used local assets, and had a flexible timeline. The CBO's power was evident in the strength of its vision, its resistance to government involvement, the occasional rejection of technical advice from EWB, and its increased confidence in its capacity to manage Tenganan's water supply. The findings reinforce the political nature of participation, with implications for approaches to establishing CBM in Indonesia and elsewhere. Strengthened outcomes in rural water supply are likely to result from greater self-reflection by external partners regarding their own positionality, coupled with a focus on strategies for maintaining and enhancing the power of CBOs

SplineAPI: A REST API for NLP Services

Modern applications often use Natural Language Processing (NLP) techniques and algorithms to provide sets of rich features. Researchers, who come up with these algorithms, often implement them for case studies, evaluation or as proof of concepts. These implementations are, in most cases, freely available for download and use. Nevertheless, these implementations do not comprise final software packages, with extensive installation instructions and detailed usage guides. Most lack a proper installation mechanism and library dependency tracking. The programming interfaces are, usually, limited to their usage through command line, or with just a few programming languages support. To overcome these shortcomings, this work aims to develop a new web platform to make available a set of common operations to third party applications that can be used to quickly access NLP based processes. Of course this platform still relies on the same tools mentioned before, as a base support to specific requests. Nevertheless, the end user will not need to install and learn their specific Application Programming Interfaces (API). For this to be possible, the architectural solution is to implement a RESTful API that hides all the tool details in a simple API that is common or, at least, coherent, across the different tools.FCT - Fundação para a Ciência e Tecnologia within the Project Scope UID/CEC/00319/201

Study of Effects of Sweep on the Flutter of Cantilever Wings

An experimental and analytical investigation of the flutter of sweptback cantilever wings is reported. The experiments employed groups of wings swept back by rotating and by shearing. The angle of sweep range from 0 degree to 60 degrees and Mach numbers extended to approximately 0.85. A theoretical analysis of the air forces on an oscillating swept wing of high length-chord ratio is developed, and the approximations inherent in the assumptions are discussed. Comparison with experiment indicates that the analysis developed in the present report is satisfactory for giving the main effects of sweep, at least for nearly uniform cantilever wings of high and moderate length-chord ratios

Non-adiabaticity and single-electron transport driven by surface acoustic waves

Single-electron transport driven by surface acoustic waves (SAW) through a narrow constriction, formed in two-dimensional electron gas, is studied theoretically. Due to long-range Coulomb interaction, the tunneling coupling between the electron gas and the moving minimum of the SAW-induced potential rapidly decays with time. As a result, nonadiabaticiy sets a limit for the accuracy of the quantization of acoustoelectric current