The calibration of photographic and spectroscopic films: Reciprocity failure and thermal responses of IIaO film at liquid nitrogen temperatures

Reciprocity failure was examined for IIaO spectroscopic film. The results indicate reciprocity failure occurs at three distinct minimum points in time; 15 min, 30 min and 90 min. The results are unique because theory suggests only one minimum reciprocity failure point should occur. When incubating 70mm IIaO film for 15 and 30 min at temperatures of 30, 40, 50, and 60 C and then placing in a liquid nitrogen bath at a temperature of -190 C the film demonstrated an increase of the optical density when developed at a warm-up time of 30 min. Longer warm-up periods of 1, 2 and 3 hrs yield a decrease in optical density of the darker wedge patterns; whereas, shorter warm-up times yield an overall increase in the optical densities

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO

A prospective, multicenter, randomized trial was undertaken to compare the efficacy and toxicity of adriamycin with mitoxantrone within a 6-drug combination chemotherapy regimen for elderly patients (older than 60 years) with high-grade non-Hodgkin lymphoma (HGL) given for a minimum of 8 weeks. A total of 516 previously untreated patients aged older than 60 years were randomized to receive 1 of 2 anthracycline-containing regimens: adriamycin, 35 mg/m2 intravenously (IV) on day 1 (n = 259), or mitoxantrone, 7 mg/m2 IV on day 1 (n = 257); with prednisolone, 50 mg orally on days 1 to 14; cyclophosphamide, 300 mg/m2 IV on day 1; etoposide, 150 mg/m2 IV on day 1; vincristine, 1.4 mg/m2 IV on day 8; and bleomycin, 10 mg/m2 IV on day 8. Each 2-week cycle was administered for a minimum of 8 weeks in the absence of progression. Forty-three patients were ineligible for analysis. The overall and complete remission rates were 78% and 60% for patients receiving PMitCEBO and 69% and 52% for patients receiving PAdriaCEBO (P = .05, P = .12, respectively). Overall survival was significantly better with PMitCEBO than PAdriaCEBO (P = .0067). However, relapse-free survival was not significantly different (P = .16). At 4 years, 28% of PAdriaCEBO patients and 50% of PMitCEBO patients were alive (P = .0001). Ann Arbor stage III/IV, World Health Organization performance status 2-4, and elevated lactate dehydrogenase negatively influenced overall survival from diagnosis. In conclusion, the PMitCEBO 8-week combination chemotherapy regimen offers high response rates, durable remissions, and acceptable toxicity in elderly patients with HGL

Mechanical loss of a hydroxide catalysis bond between sapphire substrates and its effect on the sensitivity of future gravitational wave detectors

Hydroxide catalysis bonds are low mechanical loss joints which are used in the fused silica mirror suspensions of current room temperature interferometric gravitational wave detectors, one of the techniques which was essential to allow the recent detection of gravitational radiation by LIGO. More sensitive detectors may require cryogenic techniques with sapphire as a candidate mirror and suspension material, and thus hydroxide catalysis bonds are under consideration for jointing sapphire. This paper presents the first measurements of the mechanical loss of such a bond created between sapphire substrates and measured down to cryogenic temperatures. The mechanical loss is found to be 0.03±0.01 at room temperature, decreasing to (3±1)×10−4 at 20 K. The resulting thermal noise of the bonds on several possible mirror suspensions is presented

Long-term Disease-free Survival Following Combination Multi-visceral and Metastatic Resection with Neoadjuvant FOLFIRINOX for Pancreatic Adenocarcinoma: A Case Report.

We describe a case of metastatic pancreatic adenocarcinoma treated with neoadjuvant FOLFIRINOX chemotherapy and combined pancreatic multi-visceral and metastatic liver resection in a patient currently disease-free four years after diagnosis

Words and Deeds: From Incompatibilities to Outcomes in Anti-Government Disputes

Dissidents can choose among different tactics to redress political grievances, yet violent and nonviolent mobilization tend to be studied in isolation. We examine why some countries see the emergence of organized dissident activity over governmental claims, and why in some cases these organizational claims result in civil wars or nonviolent campaigns, while others see no large-scale collective action. We develop a two-stage theoretical framework examining the organized articulation of political grievance and then large-scale violent and nonviolent collective action. We test implications of this framework using new data on governmental incompatibilities in a random sample of 101 states from 1960- 2012. We show that factors such as demography, economic development and civil society have differential effects on these different stages and outcomes of mobilization. We demonstrate that the common finding that anocracies are more prone to civil war primarily stems from such regimes being more prone to see maximalist political demands that could lead to violent mobilization, depending on other factors conducive to creating focused military capacity We find that non-democracy generally promotes nonviolent campaigns as anocracies and autocracies are both more likely to experience claims and more prone to nonviolent campaigns, conditional on claims

DRC-1339 AND DRC-2698 RESIDUES IN STARLINGS: PRELIMINARY EVALUATION OF THEIR EFFECTS ON SECONDARY HAZARD POTENTIAL

DRC-1339 (3-chloro-4-methylbenzenamine HCI) is the active ingredient in Starlicide Complete, a commercial bait used to control starlings (Sturnus vulgaris) at animal feedlots throughout the U.S. Because of the recent widespread use of this product, par- ticularly within the wintering range of many raptors, they and other avian or mammalian scavenger or predator species may be exposed to large numbers of dead or dying star- lings and blackbirds (Icteridae) throughout the winter roosting season (November-March). Acute toxicity data are available for five species of raptors and a number of mammals indicating that DRC-1339 or its primary toxic metabolite DRC-2698 (N-(3-chloro-4-methylphenyl) acetamide, CAT), a potential roost toxicant, are only moderately toxic (100-300 mg/kg) to these animals. However, there are some avian and mammalian scavengers or predators to which these compounds are considerably more toxic (i.e., cats, owls, magpies). Secondary hazards have not been observed when DRC-1339 killed starlings were fed to three raptor species for as long as 141 days and to domestic cats for seven days (DeCino, Cunningham and Schafer 1966; Holler et al. 1979, unpubl, manuscript); however, the direct long-term effects of both chemicals have not been determined on raptors or other predatory or scavenger species. In order to decide if long-term studies are needed on predator or scavenger species, it is necessary to estimate accurately the degree of expected exposure to DRC-1339 and DRC-2698under actual use conditions. Since exposure will depend primarily upon the amount of these chemicals that remains in bird carcasses from bait ingestion until death, the metabolic or excretion rate of DRC-1339 and DRC-2698 must be known in target and at-risk, nontarget bird species. Although considerable data are available to determine the metabolic or excretion rate of DRC-1339 in target birds, some of these data are conflicting. We are therefore presenting the preliminary results of some of our current research with DRC-1339 and DRC-2698

The Great Escape: A Novel Approach to Collaborative Learning (Pilot)

Healthcare continues toward team-based approaches in which multiple disciplines collaborate to ensure holistic patient care. National standards for intraprofessional collaboration guide curriculum design for entry-level occupational therapy (OT) and occupational therapy assistant (OTA) programs to ensure students acquire specific skills and knowledge needed for current OT practices. Effective intraprofessional collaboration includes effective communication, respect, trust, and understanding of role delineation, which students prefer to learn in experiential, face-to-face formats. The purpose of this study was to examine OT and OTA students’ perspectives of participating in an educational escape room (EER) as a novel experience for intraprofessional education. Investigators created an EER with a healthcare plot and conducted it at two sites with 76 students, who had 60 minutes to solve puzzles based on OT/OTA knowledge to “escape” the room. Seventy-five students provided feedback on the EER in an online survey. Participants enjoyed working together in the EER, and felt it was a fun way to apply learned skills. They reported that collaboration was a key benefit and that this learning approach made them feel like equal contributors and created a sense of accomplishment. OT educators should consider including novel game-based learning activities such as EERs in their programs and in collaboration with other programs

Boussinesq modelling of tsunami and storm wave impact

Many coastal protection structures in the UK have been designed for storm surges with appropriate return periods, but their performance during tsunami-type waves is uncertain. A shallow water and Boussinesq model is well suited to the investigation of both near-shore storm waves and tsunami waves. This paper makes use of the model to compare the effect on coastal structures of solitary waves and storm waves. Wave run-up parameters for both types of wave are generated and shown to be in good agreement with experimental data. The equations behind the model were derived assuming a small bed slope and therefore are not suitable for modelling waves interacting with vertical and near-vertical structures. However, the introduction of a reverse momentum term, to take account of a jet of water typical of a breaking wave impacting against a structure, allows wave overtopping volumes to be well predicted, although it had a minor effect on the forces acting on the structure. Comparisons with experimental data, for both solitary waves and storm waves, are presented. Using this model, the difference between the impact, in terms of wave forces and wave overtopping, of tsunami waves and storm waves for a given structure is investigated. </jats:p