Relative angular momentum balances of quasi-geostrophic circulation models

Calculations of the local vertical component of relative angular momentum are considered for quasi-geostrophic circulation models. The angular momentum diagnostic measures the net horizontal spin of the flow within an ocean basin and complements traditional budgets of energy, vorticity and linear momentum. In particular, the diagnostic can help identify the role of bottom topographic stresses in driving ocean circulation. Calculations of torque balances are presented for several numerical experiments with single-layer and multi-layer models. Experiments with an idealized continental slope topography develop a cyclonic circulation in the abyssal layer which is driven by a significant topographic form torque

Observations and modeling of seasonal variability in the Straits of Georgia and Juan de Fuca

The Strait of Georgia is a large semi-enclosed basin on the southern coast of British Columbia. Its main connection to the Pacific is to the south, through Juan de Fuca Strait. Abundant freshwater discharge, mainly from the Fraser River, forces an estuarine exchange with oceanic shelf water. The resulting circulation is modulated by tides and winds. Both the coastal wind stress and the flux of freshwater are subject to strong seasonal modulations, producing a marked seasonal cycle in the water properties and circulation of the region. The seasonal variability of the Strait of Georgia and Juan de Fuca Strait is described using data from a series of recent cruises conducted over a five-year period, in addition to longer term historical data sets. To complement the observations, the data are compared with numerical simulations based on the Princeton Ocean Model (POM). Forced with tides, freshwater discharge and seasonal wind stress, the model is integrated over a few years until the system approaches statistical equilibrium. Results show good agreement with observations from Juan de Fuca Strait, as well as over the upper part of the water column within the Strait of Georgia. However, simulation of the seasonal cycle of the deeper waters of the Strait of Georgia is more problematic. The deep water properties apparently are determined by a delicate balance between dense intrusions from the sill area and local vertical mixing

Fortnightly modulation of the estuarine circulation in Juan de Fuca Strait

Riverine discharge into the Strait of Georgia sets up a well-defined estuarine circulation within Juan de Fuca Strait, the main path for the freshwater outflow to the continental shelf. At the landward end of Juan de Fuca Strait, the water flows through narrow channels in which strong tidal currents are known to induce significant mixing of the water column, and a spring-neap modulation of the estuarine exchange. A three-dimensional prognostic numerical model has been developed to study the circulation around Vancouver Island, British Columbia. In a series of simulations, the estuarine circulation within Juan de Fuca Strait is established by the Fraser River freshwater discharge. A fortnightly modulation is imposed on the mixing over the various sills to simulate the spring-neap tidal mixing regime. The resulting variation in the estuarine circulation is found to be largely limited to the eastern section of Juan de Fuca Strait, in the vicinity of the sills. Data from current meter moorings and surface salinity data from lighthouse stations compare favorably with the model results. The effect of local wind forcing on the estuarine exchange is also examined. The model is capable of simulating those rare events during which a concurrence of river freshet, neap tide and northwest wind allows a stronger pulse of fresh surface water to escape relatively unmixed into the eastern end of Juan de Fuca Strait. The disturbance then propagates along the northern shore of the strait as a first mode internal Kelvin wave. Finally, the effect of the fortnightly modulation on the export of freshwater onto the continental shelf is examined. It is found that small amplitude coastal trapped waves are generated near the mouth of Juan de Fuca. However, this fortnightly signal is weak in comparison to the energetic wind-induced variations typically found over the shelf

The extractable power from a split tidal channel: An equivalent circuit analysis

a b s t r a c t Considerable interest exists in the possibility of exploiting strong tidal currents as a source of renewable energy. Methods to understand and evaluate this resource have been developed for simple flow configurations, such as a tidal channel linking the open ocean to an inner basin. More complicated flow geometries involving branching channels have been considered recently. A simple prototype for this class of problem consists a tidal channel that is split by an island into two sub-channels. In-stream energy conversion devices are deployed in one of the sub-channels, while the second is left free for navigation or other purposes. The free sub-channel allows flow to be diverted away from the impeded sub-channel, which may lead to a reduction in the available power. In the present paper, an electric circuit analogue is used to develop a linear theory for the power potential of a split tidal channel. Although limited to linear friction, this approach allows for inclusion of the effects of flow acceleration and finite basin size that have not been considered previously. Based on the equivalent circuit, analytical expressions are derived for the maximum extractable power and for the modification of the flow in each section of the channel at maximum power. Extension of the theory to multiple branching channels is discussed. Results for a few simple cases are considered. Crow

North Pacific internal tides from the Aleutian Ridge: Altimeter observations and modeling

Internal tides radiating into the North Pacific from the Aleutian Ridge near Amukta Pass are examined using 7 years of Topex/Poseidon altimeter data. The observations show coherent southward phase propagation at the M2 frequency over a distance of at least 1100 km into the central Pacific. Barotropic and baroclinic models are applied to study this internal tidal signal. Results from the barotropic model show that the strongest cross-slope volume and energy fluxes occur in the vicinity of Amukta Pass, helping to establish this region as an important site for baroclinic energy conversion along the eastern half of the ridge. A two-dimensional version of the Princeton Ocean Model is used to simulate internal tide generation and propagation. A comparison between the altimeter data south of the ridge and the sea-surface signature of the internal tide signal of the model shows good agreement for the phase, both close to the source and well into the far field. Comparison of the phase between model and data also provides evidence for wave refraction. This occurs due to the slow modulation of wavelength associated with the variation in the Coriolis parameter encountered as the internal tide propagates southward. The model results suggest that the net rate of conversion of barotropic to baroclinic energy is about 1.8 GW in the vicinity of Amukta Pass. This represents about 6% of the local barotropic energy flux across the ridge and perhaps 1% of global baroclinic conversion

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures

Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of the hypothalamus. Several cell biology questions associated with primary neuronal cilia signaling are challenging to address in vivo. Here we utilize primary hypothalamic neuronal cultures to study ciliary signaling in relevant cell types. Importantly, these cultures contain neuronal populations critical for appetite and satiety such as pro-opiomelanocortin (POMC) and agouti related peptide (AgRP) expressing neurons and are thus useful for studying signaling involved in feeding behavior. Correspondingly, these cultured neurons also display electrophysiological activity and respond to both local and peripheral signals that act on the hypothalamus to influence feeding behaviors, such as leptin and melanin concentrating hormone (MCH). Interestingly, we found that cilia mediated hedgehog signaling, generally associated with developmental processes, can influence ciliary GPCR signaling (Mchr1) in terminally differentiated neurons. Specifically, pharmacological activation of the hedgehog-signaling pathway using the smoothened agonist, SAG, attenuated the ability of neurons to respond to ligands (MCH) of ciliary GPCRs. Understanding how the hedgehog pathway influences cilia GPCR signaling in terminally differentiated neurons could reveal the molecular mechanisms associated with clinical features of ciliopathies, such as hyperphagia-associated obesity

Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab–Flu–Cy: the UK experience

Haematopoietic stem cell transplantation (HSCT) remains the only curative option in Fanconi anaemia (FA). We analysed the outcome of children transplanted for FA between 1999 and 2018 in the UK. A total of 94 transplants were performed in 82 patients. Among the donors, 51·2% were matched related donors (MRD) while the remainder were alternative donors. Most patients received a fludarabine–cyclophosphamide (Flu–Cy)‐based conditioning regimen (86·6%) and in vivo T‐cell depletion with alemtuzumab (69·5%). Five‐year overall survival (OS) was 85·4% [70·4–93.2] with MRD, 95·7% [72·9–99.4] with matched unrelated donors (MUD), 44·4% [6·6–78.5] with mismatched unrelated donors (MMUD) and 44·4% [13·6–71.9] with mismatched related donors (MMRD) (P < 0·001). Other factors significantly impacting OS were pre‐transplant bone marrow status, source of stem cells, cytomegalovirus (CMV) serostatus, preparation with Flu–Cy, use of total body irradiation (TBI) and alemtuzumab as serotherapy. In multivariate analysis, absence of myelodysplastic syndrome (MDS) or leukaemia, bone marrow as source of stem cells, cytomegalovirus (CMV) other than +/− (Recipient/Donor) and Flu–Cy were protective factors for five‐year OS. Five‐year chronic graft‐versus‐host‐disease (cGVHD)‐free event‐free survival was 75·4% with the same risk factors except for CMV serostatus. Five‐year non‐relapse mortality was 13·8% [7·3–22.3]. Only five patients (6·1%) developed grade II–IV acute GVHD and two patients chronic GVHD. These data confirm the excellent outcome of matched related or unrelated HSCT in children with FA

The case for developing a cohesive systems approach to research across unhealthy commodity industries.

OBJECTIVES: Most non-communicable diseases are preventable and largely driven by the consumption of harmful products, such as tobacco, alcohol, gambling and ultra-processed food and drink products, collectively termed unhealthy commodities. This paper explores the links between unhealthy commodity industries (UCIs), analyses the extent of alignment across their corporate political strategies, and proposes a cohesive systems approach to research across UCIs. METHODS: We held an expert consultation on analysing the involvement of UCIs in public health policy, conducted an analysis of business links across UCIs, and employed taxonomies of corporate political activity to collate, compare and illustrate strategies employed by the alcohol, ultra-processed food and drink products, tobacco and gambling industries. RESULTS: There are clear commonalities across UCIs' strategies in shaping evidence, employing narratives and framing techniques, constituency building and policy substitution. There is also consistent evidence of business links between UCIs, as well as complex relationships with government agencies, often allowing UCIs to engage in policy-making forums. This knowledge indicates that the role of all UCIs in public health policy would benefit from a common approach to analysis. This enables the development of a theoretical framework for understanding how UCIs influence the policy process. It highlights the need for a deeper and broader understanding of conflicts of interests and how to avoid them; and a broader conception of what constitutes strong evidence generated by a wider range of research types. CONCLUSION: UCIs employ shared strategies to shape public health policy, protecting business interests, and thereby contributing to the perpetuation of non-communicable diseases. A cohesive systems approach to research across UCIs is required to deepen shared understanding of this complex and interconnected area and also to inform a more effective and coherent response