Modelling crystal aggregation and deposition\ud in the catheterised lower urinary tract

Urethral catheters often become encrusted with crystals of magnesium struvite and calcium phosphate. The encrustation can block the catheter, which can cause urine retention in the bladder and reflux into the kidneys. We develop a mathematical model to investigate crystal deposition on the catheter surface, modelling the bladder as a reservoir of fluid and the urethral catheter as a rigid channel. At a constant rate, fluid containing crystal particles of unit size enters the reservoir, and flows from the reservoir through the channel and out of the system. The crystal particles aggregate, which we model using Becker–Döring coagulation theory, and are advected through the channel, where they continue to aggregate and are deposited on the channel’s walls. Inhibitor particles also enter the reservoir, and can bind to the crystals, preventing further aggregation and deposition. The crystal concentrations are spatially homogeneous in the reservoir, whereas the channel concentrations vary spatially as a result of advection, diffusion and deposition. We investigate the effect of inhibitor particles on the amount of deposition. For all parameter values, we find that crystals deposit along the full length of the channel, with maximum deposition close to the channel’s entrance

MULTIPAC, a multiple pool processor and computer for a spacecraft central data system, phase 2 Final report

MULTIPAC, multiple pool processor and computer for deep space probe central data syste

Decision Support Design for Workload Mitigation in Human Supervisory Control of Multiple Unmanned Aerial Vehicles

As UAVs become increasingly autonomous, the multiple personnel currently required to operate a single UAV may eventually be superseded by a single operator concurrently managing multiple UAVs. Instead of lower-level tasks performed by today’s UAV teams, the sole operator would focus on high-level supervisory control tasks such as monitoring mission timelines and reacting to emergent mission events. A key challenge in the design of such single-operator systems will be the need to minimize periods of excessive workload that could arise when critical tasks for several UAVs occur simultaneously. To a certain degree, it is possible to predict and mitigate such periods in advance. However, actions that mitigate a particular period of high workload in the short term may create long term episodes of high workload that were previously non-existent. Thus some kind of decision support is needed that facilitates an operator’s ability to evaluate different options for managing a mission schedule in real-time. This paper describes two decision support visualizations designed for supervisory control of four UAVs performing a time-critical targeting mission. A configural display common to both visualizations, named the StarVis, was designed to highlight potential periods of high workload corresponding to the current mission timeline, as well as “what if” projections of possible high workload periods based upon different operator options. The first visualization design allows an operator to compare different high workload mitigation options for individual UAVs. This is termed the local visualization. The second visualization is indicates the combined effects of multiple high workload mitigation decisions on the timeline. This is termed the global visualization. The main advantage of the local visualization is that options can be compared directly; however, the possible effects of these options on the mission timeline are only indicated for the individual UAV primarily affected by the decision. For the global visualization, different decisions can be combined to show possible effects on the system propagated across all UAVs, but the different alternatives of a single decision option alternative cannot be directly compared. An experiment was conducted testing these visualizations against a control with no visualization. Results showed that subject using the local visualization had better performance, higher situational awareness, and no significant increase in workload over the other two experimental conditions. This occurred despite the fact that the local and global StarVis displays were very similar. Not only did the Global StarVis produce degraded results as compared to the local StarVis, but those participants with no visualization performed as well as those with the global StarVis. This disparity in performance despite strong visual similarities in the StarVis designs is attributed to operators’ inability to process all the information presented in the global StarVis as well as the fact that participants with the local StarVis were able to rapidly develop effective cognitive problem strategies. This research effort highlights a very important design consideration, in that a single decision support design can produce very different performance results when applied at different levels of abstraction.Prepared for Kevin Burns, The MITRE Corporatio

Physician-facilitated designation of proxy decision maker.

With vast improvements in healthcare in recent decades, people are living longer but often with higher rates of morbidity and chronic illnesses. This has resulted in a higher proportion of the population who may benefit from early end-of-life 'conversation and planning', but also gives healthcare professionals more time during which these discussions are relevant, as people live longer with their chronic diseases. A survey conducted by Lifshitz et al (Isr J Health Policy Res 5:6, 2016) sought to assess physician awareness and willingness to discuss designating a proxy decision-maker with patients, in order to aid end-of-life care in the event that the patient is rendered unable to make or communicate these decisions later in life. Their article suggests that proxy decision-maker designation is only one aspect of end-of-life care; a challenging area littered with ethical and moral dilemmas. Without early, open and frank discussions with patients regarding their wishes at the end of life, proxy decision-makers may be in no better position than physicians or a court appointed proxy to make decisions in the patients' best interests/benefits. This commentary also touches upon the use of health and care passports being developed or in early phases in the United Kingdom, and whether these may be utilised in the field of palliative care in Israel

Direct excitation of the forbidden clock transition in neutral 174Yb atoms confined to an optical lattice

We report direct single-laser excitation of the strictly forbidden (6s^2)^1S_0 -(6s6p)^3P_0 clock transition in the even 174Yb isotope confined to a 1D optical lattice. A small (~1.2 mT) static magnetic field was used to induce a nonzero electric dipole transition probability between the clock states at 578.42 nm. Narrow resonance linewidths of 20 Hz (FHWM) with high contrast were observed, demonstrating a record neutral-atom resonance quality factor of 2.6x10^13. The previously unknown ac Stark shift-canceling (magic) wavelength was determined to be 759.35+/-0.02 nm. This method for using the metrologically superior even isotope can be easily implemented in current Yb and Sr lattice clocks, and can create new clock possibilities in other alkaline earth-like atoms such as Mg and Ca.Comment: Submitted to Physics Review Letter

Developing Lunar Landing Vehicle Display Requirements through Content Analysis of Apollo Lunar Landing Voice Communications

The lengthy period since the Apollo landings limits present-day engineers attempting to draw from the experiences of veteran Apollo engineers and astronauts in the design of a new lunar lander. In order to circumvent these limitations, content analyses were performed on the voice transcripts of the Apollo lunar landing missions. The analyses highlighted numerous inefficiencies in the design of the Apollo Lunar Module displays, particularly in the substantial use of the cognitive resources of the Lunar Module Pilot in the performance of low-level tasks. The results were used to generate functional and information requirements for the next-generation lunar lander cockpit.This research was sponsored by NASA and Draper Laboratory

Fluorescence measurements of expanding strongly-coupled neutral plasmas

We report new detailed density profile measurements in expanding strongly-coupled neutral plasmas. Using laser-induced fluorescence techniques, we determine plasma densities in the range of 10^5 to 10^9/cm^3 with a time resolution limit as small as 7 ns. Strong-coupling in the plasma ions is inferred directly from the fluorescence signals. Evidence for strong-coupling at late times is presented, confirming a recent theoretical result.Comment: submitted to PR

Past, Present And Future Implications Of Human Supervisory Control In Space Missions

Achieving the United States’ Vision for future Space Exploration will necessitate far greater collaboration between humans and automated technology than previous space initiatives. However, the development of methodologies to optimize this collaboration currently lags behind development of the technologies themselves, thus potentially decreasing mission safety, efficiency and probability of success. This paper discusses the human supervisory control (HSC) implications for use in space, and outlines several areas of current automated space technology in which the function allocation between humans and machines/automation is sub-optimal or under dispute, including automated spacecraft landings, Mission Control, and wearable extra-vehicular activity computers. Based on these case studies, we show that a more robust HSC research program will be crucial to achieving the Vision for Space Exploration, especially given the limited resources under which it must be accomplished

Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls.

Previous studies showed exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) enhances the development of endometriotic lesions. In this study we examined the effects of other polyhalogenated aromatic hydrocarbons on endometriotic proliferation. B6C3F1 female mice were treated via oral gavage a total of five times, with 3 weeks between each dosing, with 0, 1, 3, or 10 micrograms 2,3,7,8,-TCDD/kg body weight (bw); 3 or 30 mg 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153)/kg bw; 100, 300, or 1000 micrograms 3,3',4,4',5-pentachlorobiphenyl (PCB 126)/kg bw; 10, 30, or 100 micrograms 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF)/kg bw; or 2 or 20 mg 1,3,6,8-TCDD/kg at 10 ml/kg bw. Endometriosis was surgically induced during the week of the second dosing. Three weeks following the final dose, the mice were euthanized and endometriotic lesions, whole body, liver, ovaries, uterine horn, and thymus were weighted, and lesion diameters were measured. Lesions, uterine horns, and ovaries were fixed for histopathology and livers were processed for measurement of ethoxyresorufin O-deethylase (EROD) activity. Both 2,3,7,8-TCDD (1 and 3 micrograms/kg bw) and 4-PeCDF (100 micrograms/kg bw) significantly enhanced the growth of endometrial lesions. No statistically significant increase in endometriotic lesion size was detected in animals treated with either PCB 126 or with the highest dose of 2,3,7,8-TCDD, possibly due to the effects of histologically observed ovarian toxicity. The nondioxin-like compounds, PCB 153 and 1,3,6,8-TCDD, produced no observable effects on endometriosis. Hepatic EROD activity was significantly induced by 2,3,7,8-TCDD, 4-PeCDF, and PCB 126, but not by PCB 153 or 1,3,6,8-TCDD. The results of this study provide preliminary support for the hypothesis that halogenated aromatic hydrocarbon-promoted endometriosis may be Ah receptor mediated