Quantifying the Coastal Hazard Risk Reduction Benefits of Coral Reef Restoration in the U.S. Virgin Islands

Coastal habitat restoration, especially of coral reef ecosystems, can significantly reduce the exposure of coastal communities to natural hazards and, consequently, the risk of wave-driven flooding. Likewise, reef degradation can increase coastal flood risks to people and property. In this study, the valuation of coral reefs in the United States Virgin Islands (USVI), along the coasts of St. Croix, St. John, and St. Thomas, demonstrated the social and economic benefits provided by these natural defenses. Across the territory, more than 481 people and 31.2 million of infrastructure were estimated to receive protection from coral reefs per year (2010 U.S. dollars). In 2017, Hurricanes Irma and Maria significantly damaged coral reefs throughout the archipelago. By combining engineering, ecological, geospatial, social, and economic data and tools, this study provided a rigorous valuation of where potential coral reef restoration projects could help rebuild these damaged habitats and decrease the risks from coastal hazards faced by USVI’s reef-fronted communities. Multiple restoration scenarios were considered in the analysis, two of which are detailed in this report. These include (1) ‘Ecological’ restoration, where restoration creates a structure that is 0.25 m high and 25-m-wide reef, and (2) ‘Hybrid’ restoration, where restoration creates a structure that is 1.25 m high and 5 m wide. There are many ways that such structures could be developed. In the hydrodynamic analyses, there are no assumptions about how the restoration is developed. Many practitioners of both coral (and oyster reef) restoration consider that a reef height of 0.25 m might be delivered from planting corals alone and that 1.25 m might require a combination of artificial structures and coral planting. In a third scenario, the analysis investigated the reduction of protection benefits that would occur through the reduction of 1 meter of naturally occurring reef height due to reef degradation. The reduction of protection due to the loss of reefs can also be interpreted as the protection value of the existing reefs. In all studied restoration scenarios, it was assumed that the planting of corals would enhance hydrodynamic roughness, effectively dissipating incident wave energy and reducing the potential for coastal flooding. A standardized approach was employed to strategically locate potential restoration projects along the entire linear extent of existing reefs bordering the USVI, and to identify where coral reef restoration could offer valuable benefits in flood reduction. Potential restoration projects were only located within the existing distribution of reefs across the region, even though numerous sites were positioned far offshore (2-3 km), and some were at relatively deep depths (up to 7 m). Risk-based valuation approaches were followed to delineate flood zones at a 10 m2 resolution along the entire region's reef-lined shorelines for all the potential coral reef restoration scenarios. These were subsequently compared to flood zones without coral reef restoration. The potential reduction in coastal flood risk provided by coral reef restoration, and the protection value of existing reefs, were quantified utilizing the latest information available at the time of analysis from the U.S. Census Bureau, Federal Emergency Management Agency (FEMA), and Bureau of Economic Analysis for return-interval storm events. The change in Expected Annual Damages (EAD), a metric indicating the annual protection gained due to coral reef restoration, was calculated based on the damages associated with each storm probability. The findings suggest that the benefits of reef restoration are spatially variable within the USVI. In some areas, the analysis showed limited benefits from reef restoration, which may be attributed to the depth or offshore distances of proposed restoration sites. However, there were a number of key areas where reef restoration could have substantial benefits for flood risk reduction. The annual flood risk reduction attributed to potential ‘ecological’ coral reef restoration in the USVI was 99 people and 6.1 million (2010 U.S. dollars). The Benefit-to-Cost Ratio (BCR) for this restoration approach was found to be larger than 1 (i.e., cost-effective) along 11% of the St. Croix coastline, 4.9% of the St. John coastline, and 8.7% of the St. Thomas coastline. This analysis offers stakeholders and decision-makers a spatially explicit and rigorous evaluation that illustrates how, where, and when potential coral reef restoration efforts in St. Croix, St. John, and St. Thomas could be instrumental to reducing coastal storm-induced flooding. Understanding areas where reef management, recovery, and restoration could effectively reduce climate hazard-related risks is crucial to protect and enhance the resilience of coastal communities in USVI

Exploring the nature and synchronicity of early cluster formation in the Large Magellanic Cloud - IV. Evidence for multiple populations in Hodge 11 and NGC 2210

We present a multiple population search in two old Large Magellanic Cloud (LMC) Globular clusters, Hodge 11 and NGC 2210. This work uses data from the Advanced Camera for Surveys and Wide Field Camera 3 on the Hubble Space Telescope from programme GO- 14164 in Cycle 23. Both of these clusters exhibit a broadened main sequence with the second population representing (20±~5) per cent forNGC2210 and (30±~5) per cent forHodge 11. In both clusters, the smaller population is redder than the primary population, suggesting CNO variations. Hodge 11 also displays a bluer second population in the horizontal branch, which is evidence for helium enhancement. However, even though NGC 2210 shows similarities to Hodge 11 in the main sequence, there does not appear to be a second population on NGC 2210's horizontal branch. This is the first photometric evidence that ancient LMC Globular clusters exhibit multiple stellar populations.Fil: Gilligan, Christina K.. Dartmouth College; Estados UnidosFil: Chaboyer, Brian. Dartmouth College; Estados UnidosFil: Cummings, Jeffrey D.. University Johns Hopkins; Estados UnidosFil: Mackey, Dougal. Australian National University. Research School of Astronomy & Astrophysics; AustraliaFil: Cohen, Roger E.. Space Telescope Science Institute; Estados UnidosFil: Geisler, Douglas. Universidad de La Serena; ChileFil: Grocholski, Aaron J.. University of Washington; Estados UnidosFil: Parisi, Maria Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Sarajedini, Ata. University of Florida; Estados UnidosFil: Ventura, Paolo. Osservatorio Astronomico Di Roma; ItaliaFil: Villanova, Sandro. Universidad de Concepción; ChileFil: Yang, Soung-Chul. Korea Astronomy And Space Science Institute; Corea del SurFil: Wagner-Kaiser, Rachel. University of Florida; Estados Unido

Exploring the nature and synchronicity of early cluster formation in the Large Magellanic Cloud - V. Multiple populations in ancient globular clusters

We examine four ancient LargeMagellanic Cloud (LMC) globular clusters (GCs) for evidence of multiple stellar populations using the Advanced Camera for Surveys andWide Field Camera 3 on the Hubble Space Telescope Programme GO-14164. NGC 1466, NGC 1841, and NGC 2257 all show evidence for a redder, secondary population along themain sequence. Reticulum does not showevidence for the presence of a redder population, but thisGChas the least number of stars and Monte Carlo simulations indicate that the sample of main-sequence stars is too small to robustly infer whether a redder population exists in this cluster. The second, redder, population of the other three clusters constitutes ∼ 30 - 40 per cent of the total population along the main sequence. This brings the total number of ancient LMC GCs with known split or broadened main sequences to five. However, unlike for Hodge 11 and NGC 2210 (see Gilligan et al. (2019)), none of the clusters shows evidence for multiple populations in the horizontal branch. We also do not find evidence of a second population along the red giant branch.Fil: Gilligan, Christina K.. Dartmouth College; Estados UnidosFil: Chaboyer, Brian. Dartmouth College; Estados UnidosFil: Cummings, Jeffrey D.. University Johns Hopkins; Estados UnidosFil: Mackey, Dougal. Australian National University; AustraliaFil: Cohen, Roger E.. Space Telescope Science Institute; Estados UnidosFil: Geisler, Douglas. Universidad de Concepción; ChileFil: Grocholski, Aaron J.. University of Florida; Estados UnidosFil: Parisi, Maria Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Sarajedini, Ata. University of Florida; Estados UnidosFil: Ventura, Paolo. Osservatorio Astronomico Di Roma; ItaliaFil: Villanova, Sandro. Universidad de Concepción; ChileFil: Yang, Soung-Chul. Korea Astronomy And Space Science Institute; Corea del SurFil: Wagner-Kaiser, Rachel. University of Florida; Estados Unido

Off-target piRNA gene silencing in Drosophila melanogaster rescued by a transposable element insertion

Transposable elements (TE) are selfish genetic elements that can cause harmful mutations. In Drosophila, it has been estimated that half of all spontaneous visible marker phenotypes are mutations caused by TE insertions. Several factors likely limit the accumulation of exponentially amplifying TEs within genomes. First, synergistic interactions between TEs that amplify their harm with increasing copy number are proposed to limit TE copy number. However, the nature of this synergy is poorly understood. Second, because of the harm posed by TEs, eukaryotes have evolved systems of small RNA-based genome defense to limit transposition. However, as in all immune systems, there is a cost of autoimmunity and small RNA-based systems that silence TEs can inadvertently silence genes flanking TE insertions. In a screen for essential meiotic genes in Drosophila melanogaster, a truncated Doc retrotransposon within a neighboring gene was found to trigger the germline silencing of ald, the Drosophila Mps1 homolog, a gene essential for proper chromosome segregation in meiosis. A subsequent screen for suppressors of this silencing identified a new insertion of a Hobo DNA transposon in the same neighboring gene. Here we describe how the original Doc insertion triggers flanking piRNA biogenesis and local gene silencing. We show that this local gene silencing occurs in cis and is dependent on deadlock, a component of the Rhino-Deadlock-Cutoff (RDC) complex, to trigger dual-strand piRNA biogenesis at TE insertions. We further show how the additional Hobo insertion leads to de-silencing by reducing flanking piRNA biogenesis triggered by the original Doc insertion. These results support a model of TE-mediated gene silencing by piRNA biogenesis in cis that depends on local determinants of transcription. This may explain complex patterns of off-target gene silencing triggered by TEs within populations and in the laboratory. It also provides a mechanism of sign epistasis among TE insertions, illuminates the complex nature of their interactions and supports a model in which off-target gene silencing shapes the evolution of the RDC complex

Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis. While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to lysis, suggesting that the action of Hla may not be solely conferred by lytic susceptibility. Using intravital microscopy, we observed that Hla disrupts neutrophil localization and clustering early in infection. Hla forms a narrow, ion-selective pore, suggesting that Hla may dysregulate calcium or other ions to impair neutrophil function. We found that sub-lytic Hla did not permit calcium influx but caused rapid membrane depolarization. Depolarization decreases the electrogenic driving force for calcium, and concordantly, Hla suppressed calcium signaling in vitro and in vivo and calcium-dependent leukotriene B4 (LTB4) production, a key mediator of neutrophil clustering. Thus, Hla disrupts the early patterning of the neutrophil response to infection, in part through direct impairment of neutrophil calcium signaling. This early mis-localization of neutrophils may contribute to establishment of infection

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Caracterización de los espacios rurales en El Salvador a partir de estadísticas nacionales

En este estudio se reflexiona sobre los límites y alcances de las definiciones de ruralidad prevalecientes y se propone una caracterización alternativa del territorio rural en El Salvador. A partir de los elementos del debate regional pertinentes para el país, se elabora una revisión de las definiciones de territorio rural basada en las estadísticas nacionales. Atendiendo a dicha revisión y retomando los conceptos de la nueva ruralidad, se propone una conceptualización alternativa que permite establecer cuatro definiciones de territorio rural. En la primera definición, se retoma la clásica caracterización dicotómica de territorio rural y urbano mediante un monocriterio poblacional; en la segunda, se incorpora la dimensión de la intensidad de luz obtenida a partir de fotografías satelitales; en la tercera, se añade la funcionalidad territorial, dimensión que comprende variables como la densidad de actividad económica, infraestructura y equipamiento del territorio o servicios públicos y, en la cuarta, se agrega la dimensión de precariedad, que incluye variables como calidad de vivienda, ingreso, sostenibilidad ambiental y migración en el territorio. En este trabajo se transforma la dicotomía urbano‑rural en una tipología de ocho tipos de territorio, que refleja mejor su diversidad y se perfila como un instrumento más adecuado de política territorial.Resumen .-- Introducción .-- I. La nueva ruralidad .-- II. Definición de rural en El Salvador .-- III. Hacia una nueva definición de ruralidad en El Salvador .-- IV. Conclusiones y recomendaciones

The effects of organic nitrates on osteoporosis: a randomized controlled trial [ISRCTN94484747]

<p>Abstract</p> <p>Background</p> <p>Osteoporotic fractures are common and are associated with increased morbidity, mortality and health care costs. The most effective way to moderate increases in health care costs and the sickness and premature death associated with osteoporotic fractures, is to prevent osteoporosis. Several lines of evidence suggest that nitrates, drugs typically prescribed for the treatment of angina, may be effective in preventing postmenopausal osteoporosis.</p> <p>Methods</p> <p>We have designed a multicentre randomized controlled trial to determine the effects of nitrates on bone. The trial consists of two studies. The objective of the first study is to determine whether isosorbide mononitrate at 20 mg/day or nitroglycerin ointment at 15 mg/day leads to fewer headaches. The nitrate that is best tolerated will be used in a second study with one main objective: To determine if postmenopausal women with a T-score at the lumbar spine (L1 to L4) between 0 and -2.0 randomized to two years of treatment with intermittent nitrates have a greater increase in spine bone mineral density as compared to women randomized to placebo.</p> <p>We hypothesize that: 1. Women will report fewer headaches when they are randomized to intermittent nitroglycerin ointment at 15 mg/day compared to intermittent oral isosorbide mononitrate at 20 mg/day, and, 2. After two years, women randomized to intermittent nitrates will have a greater percent increase in lumbar spine bone mineral density compared with women randomized to placebo.</p> <p>Discussion</p> <p>We have completed our pilot study and found that transdermal nitroglycerin was associated with fewer headaches than oral isosorbide mononitrate. We are currently recruiting patients for our second main study.</p