530 research outputs found
Advances and challenges in geroscience research: An update
Aging remains the most pervasive risk factor for a wide range of chronic diseases that afflict modern societies. In the United States alone, incidence of age-related diseases (e.g., cardiovascular disease, stroke, Alzheimer’s disease, vascular cognitive impairment and dementia, cancer, hypertension, type-2 diabetes, chronic obstructive pulmonary disease, and osteoarthritis) is on the rise, posing an unsustainable socioeconomic burden even for the most developed countries. Tackling each and every age-related disease alone is proving to be costly and ineffective. The emerging field of geroscience has posed itself as an interdisciplinary approach that aims to understand the relationship between the biology of aging and the pathophysiology of chronic age-related diseases. According to the geroscience concept, aging is the single major risk factor that underlies several age-related chronic diseases, and manipulation of cellular and systemic aging processes can delay the manifestation and/or severity of these age-related chronic pathologies. The goal of this endeavor is to achieve health improvements by preventing/delaying the pathogenesis of several age-related diseases simultaneously in the elderly population by targeting key cellular and molecular processes of aging instead of managing diseases of aging as they arise individually. In this review, we discuss recent advances in the field of geroscience, highlighting their implications for potential future therapeutic targets and the associated scientific challenges and opportunities that lay ahead
Security of Quantum Key Distribution with entangled quNits
We consider a generalisation of Ekert's entanglement-based quantum
cryptographic protocol where qubits are replaced by quits (i.e.,
N-dimensional systems). In order to study its robustness against optimal
incoherent attacks, we derive the information gained by a potential
eavesdropper during a cloning-based individual attack. In doing so, we
generalize Cerf's formalism for cloning machines and establish the form of the
most general cloning machine that respects all the symmetries of the problem.
We obtain an upper bound on the error rate that guarantees the confidentiality
of quNit generalisations of the Ekert's protocol for qubits.Comment: 15 pages, equation 15 and conclusions corrected the 14th of April
2003, new results adde
Health Impacts of Consumer Exposure During Product Use: Near Field Exposure Applied to Risk Assessment and LCA
Two-parameter deformations of logarithm, exponential, and entropy: A consistent framework for generalized statistical mechanics
A consistent generalization of statistical mechanics is obtained by applying
the maximum entropy principle to a trace-form entropy and by requiring that
physically motivated mathematical properties are preserved. The emerging
differential-functional equation yields a two-parameter class of generalized
logarithms, from which entropies and power-law distributions follow: these
distributions could be relevant in many anomalous systems. Within the specified
range of parameters, these entropies possess positivity, continuity, symmetry,
expansibility, decisivity, maximality, concavity, and are Lesche stable. The
Boltzmann-Shannon entropy and some one parameter generalized entropies already
known belong to this class. These entropies and their distribution functions
are compared, and the corresponding deformed algebras are discussed.Comment: Version to appear in PRE: about 20% shorter, references updated, 13
PRE pages, 3 figure
Exposure and Toxicity Modeling of Chemicals in Personal Care Products: Case Study Using Parabens
Controlling orbital moment and spin orientation in CoO layers by strain
We have observed that CoO films grown on different substrates show dramatic
differences in their magnetic properties. Using polarization dependent x-ray
absorption spectroscopy at the Co L edges, we revealed that the
magnitude and orientation of the magnetic moments strongly depend on the strain
in the films induced by the substrate. We presented a quantitative model to
explain how strain together with the spin-orbit interaction determine the 3d
orbital occupation, the magnetic anisotropy, as well as the spin and orbital
contributions to the magnetic moments. Control over the sign and direction of
the strain may therefore open new opportunities for applications in the field
of exchange bias in multilayered magnetic films
Tier 2 High-Throughput Exposure Screening of Chemicals in Consumer Products: Chemicals encapsulated in articles and in cosmetics
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