Minimal data set

Minimal data set for 2017 PLOS ONE article "Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome"

Copeptin and NSE levels after birth in relation to two-year outcome.

<p>(A) Copeptin levels were significantly higher in neonates in the poor outcome group (n = 25) than in the favorable outcome group (n = 50) at 6 hours (p = 0.0068), 12 hours (p = 0.0050) and 48 hours (p = 0.0226) after birth. (B) NSE levels were significantly higher in the neonates in the poor outcome group compared to the favorable outcome group at all time points (p = 0.0009 at 6 hours, p = 0.0005 at 12 hours, p = 0.0005 at 24 hours, p = 0.0009 at 48 hours, and p = 0.0029 at 72 hours). (C-D) ROC curves of combined copeptin and NSE concentrations at 6 hours (C) and 12 hours (D) after birth in relation to two year neurodevelopmental outcome. Graphs A and B show the median ± IQR. The data for each time point were analyzed separately with the Mann-Whitney U-test, and the Holm-Sidak method was used to compute thresholds to ensure a family-wise error rate below 0.05.</p

Copeptin levels in relation to therapeutic hypothermia.

<p>Copeptin concentrations after birth were lower in the hypothermic neonates from the TOBY cohort (n = 11) compared to the normothermic neonates from the same cohort (n = 10) at 6 hours after birth (p = 0.0495). Graph shows the median ± IQR. The data for each time point was analyzed separately with the Mann-Whitney U-test, and the Holm-Sidak method was used to compute thresholds to ensure a family-wise error rate below 0.05.</p

Clinical characteristics of the study groups.

<p>Clinical characteristics of the study groups.</p

Copeptin and NSE concentrations in serum samples over time (n = 75).

<p>(A, B) Copeptin levels decrease over time, with highest levels measured at 6 hours after birth. Copeptin concentrations are shown for individual neonates (A) as well as the median ±IQR concentration for each time point (B). Compared to the 6 hour time point, concentrations were significantly lower at all subsequent time points (p = 0.0448 at 6 vs. 12 hours, and p < 0.0001 at all other time points). (C, D) NSE levels are relatively stable until 24 h after birth, after which the levels decrease. Data is shown for individual neonates (C) and as the median ± IQR at each time point (D). Compared to the 6 hour time point, concentrations were significantly lower only at 168 hours after birth (p = 0.0013). The Kruskal-Wallis test with Dunn’s multiple comparisons test was used.</p