66 research outputs found
Investigation of the central regulation of taste perception and metabolism in human and animal experiments
8
Investigating the pathomechanisms of renal fibrosisin animal models : Diabetic and toxic nephropathy.
Network analysis of protein dynamics
The network paradigm is increasingly used to describe the topology and
dynamics of complex systems. Here we review the results of the topological
analysis of protein structures as molecular networks describing their
small-world character, and the role of hubs and central network elements in
governing enzyme activity, allosteric regulation, protein motor function,
signal transduction and protein stability. We summarize available data how
central network elements are enriched in active centers and ligand binding
sites directing the dynamics of the entire protein. We assess the feasibility
of conformational and energy networks to simplify the vast complexity of rugged
energy landscapes and to predict protein folding and dynamics. Finally, we
suggest that modular analysis, novel centrality measures, hierarchical
representation of networks and the analysis of network dynamics will soon lead
to an expansion of this field.Comment: 10 pages, 2 figures, 1 tabl
Felsőtesti koordináció és a nyomásközponti trajektóriák regisztrálása kerekesszékben izomdystrophias betegekben = Recording Trajectory of Upper-Body Coordination and Pressure Centre Points in Wheelchair Patients with Muscle Dystrophy
Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands
Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria. © 2016 Akadémiai Kiadó, Budapest, Hungar
Schiff-bázisokkal képzett vas(II)-komplexek szintézise, fizikaikémiai és biológiai aktivitásuk vizsgálata = Synthesis of Fe(II)-complexes with Schiff bases, physical chemical and biological activity study
Novel cobalt complexes with glyoximes : synthesis, physicochemical analysis and biological study
Azomethine derivatives have several applications, especially as reagents for the determination of transition metal ions. Furthermore these ligands and their cobalt complexes were also reported to possess biological activities, such as antimicrobial, anti-tubercular, anticonvulsant, anti-inflammatory, anti-proliferative activities as well as antifungal inhibition potential [1]. Another reason for using metal-containing compounds as structural scaffolds is related to the kinetic stability of their coordination spheres in the biological environment. Metallic ions have been shown to play important role in the biological activity of different compounds in such away that, in some cases, activity is enhanced or only takes place in the presence of these ions [2]. In our research new cobalt(III) complexes were synthesized with -glyoximes, azides, amines, thiocyanate and halogens, such as [Co(Me-propyl-GlyoxH)2(N3)(amine)], [Co(Mepentyl-GlyoxH)2(N3)(amine)], [Co(Et-propyl-GlyoxH)2(N3)(amine)], [Co(Et-propylGlyoxH)2(Br)(amine)], [Co(Et-propyl-GlyoxH)2(SCN)(amine)], H[Co(Et-propylGlyoxH)2(SCN)2], [Co(phenyl-Me-GlyoxH)2(amine)2]I, [Co(Et-propyl-GlyoxH)2(amine)2]I, [Co(Et-Bu-GlyoxH)2(amine)2]I, where GlyoxH = mono deprotonated glyoxime, and the used amines: imidazole, 3-hydroxy-aniline, lepidine, 3,5-dimethyl-pyridine, di(n-butyl)-amine, diisopropyl-amine, 2-amino-pyrimidine, diphenyl-amine, 2-picoline, 3-picoline. The Co(II)- acetate salt dissolved in water and mixed with the glyoxime alcoholic solution was oxidized by air bubbling, then the corresponding diamines and the other complexing agents were added. The molecular structure of our products was investigated by IR, UV–VIS spectroscopy, mass spectrometry (MS), thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity, like antimicrobial effect, was studied for a few bacteria
Novel platinum complexes with schiff bases and α-Dioximes, their physico-chemical and biological study
In our research project we prepared the following platinum(II) complexes with Schiff bases and -dioximes, such as [Pt(ketone)2A(L2)], (ketone: 2-heptanone, 2-octanone, 3-octanone; A: hydrazine, phenylhydrazine, o-phenylene-diamine; L: 1-naphthylamine, 2-aminopyrimidine, 2-methylimidazole, 2-amino-4-methylpyridine) and [Pt(DioxH)2L2], (DioxH2: methyl-phenyl-dioxime, butyl-methyl-dioxime; L: 1-naphthylamine, 2-methylimidazole, 2-amino-4-methylpyridine, lepidine, 2-methylpyridine, m-toluidine, dicyclohexylamine, 4-isopropylamine, cyclohexylamine), by the reaction of PtCl2 in suitable solvent. After a short bibliographical survey, involving the classification and evolution of platinum complexes with possible applications, we analyzed their physico-chemical properties using FTIR, Raman, NMR, UV-VIS spectroscopy, powder X-ray diffraction (XRD), mass spectrometry, thermal analysis (TG, DTG, DTA) and SEM. We also studied the antibacterial effect of complexes on different strains of bacteria. This class of compounds has relevance in biochemistry, some of them are antibacterial agents and potential anti-tumor drugs
- …