8 research outputs found
The Effects of Long-Term, Low- and High-Dose Beta-Carotene Treatment in Zucker Diabetic Fatty Rats: the Role of HO-1
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Evaluation of systemic and dermal toxicity and dermal photoprotection by sour cherry kernels
The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased during Reperfusion in Fibrillated Mouse Hearts
The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria
Synthesis, in Vitro Biological Evaluation, and Oxidative Transformation of New Flavonol Derivatives: The Possible Role of the Phenyl-N,N-Dimethylamino Group
Six new flavonols (6aâf) were synthesized with ClaisenâSchmidt and Suzuki reactions and they
were fully characterized by spectroscopic methods. In order to evaluate their antioxidant activities, their
oxygen radical absorption capacity and ferric reducing antioxidant power were measured, along with
their free radical scavenging activity against 2,20
-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)
and 2,2-diphenyl-1-picrylhydrazylradicals. In addition, their cytotoxicity on H9c2 cardiomyoblast
cells was also assessed by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Compounds bearing the phenyl-N,N-dimethylamino group (6a, 6c, and 6e) exhibited promising
antioxidant potency and did not have any cytotoxic effect. After a consideration of these data, the oxidative
transformation of the 6c compound was investigated in vitro with a chemical Fenton reaction and the
identification of the formed oxidation products was performed by mass spectrometry. Two potential
metabolites were detected. Based on these results, compound 6c can be a model compound for future
developments. Overall, this work has proved the involvement of the phenyl-N,N-dimethylamino group
in the antioxidant activity of flavonols