The effect of aerobic training on healthy elderly women’s walking speed, step length and habitual physical activity

This study’s main aim was to investigate whether training could increase walking speed, step length and habitual physical activity (HPA) in elderly women. This randomized controlled trial was carried out with 22 elderly women, who were first monitored for a week (heart rate and movement), had their chosen and faster walking speed determined, as well as their step rate and length, and underwent sub maximal treadmill tests. Data from monitoring were organized into 7 HPA indices. The women were randomly allocated to a control (73.6±1.7 years) or exercise group (75.5±2.9). For 12 weeks the exercisers walked 3 times a week on a treadmill at 60-65% of their predicted HRR. Controls continued with their normal routine. Post-training, all measurements were repeated. Training was associated with significant increases in step length and walking speeds. However, no significant changes in the HPA indices were found. It is concluded that the three-month aerobic training program by treadmill walking resulted in significant increases in steplength and self-selected walking speeds in these healthy, independent, elderly women, however, it did not lead to increased habitual physical activity

Monitoramento de suscetibilidade a pesticidas organofosforados em Anastrepha fraterculus (diptera : tephritidae)

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The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis

Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. ,e aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance

O polimorfismo G894T do gene da óxido nítrico sintase endotelial (NOSe) não está associado com uma incidência maior de revascularização da lesão alvo pós-implante de stent intracoronário

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Análise da associação dos polimorfismos G894T do gene da óxido nítrico sintase endotelial (NOSE) e C(-260)-T do promotor do gene do receptor CD14 de monócitos com angina instável

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Reflexões sobre biogerontologia como uma ciência generalista, integrativa e interativa

O texto compila conceitos e informações relacionados com um ramo recente da biologia do desenvolvimento, denominado biogerontologia ou biologia do envelhecimento. Reflexões sobre o conjunto de conhecimentos relatado, associado a aspectos sociais, antropológicos e psicológicos são feitas. A síntese do texto, preconiza a importância de rompermos com a ignorância a respeito das modificações associadas ao envelhecimento humano como uma forma de manejar de modo adequado este período da vida auxiliando, deste modo, na diminuição da marginalização e isolamento do idoso que acontece na nossa sociedade.The text resumes concepts and informations related to a recent branch of the biology of development, named biogerontology or biology of aging. Reflections about the knowledge, associated to social, antropological and psicological aspects are made. The synthesis of the text precognize the importance of breaking the ignorance about the modifications related to human aging as a way to handle in a good way this time of life, and, in this way help to lower the marginalization and isolation of the elder that happens in our society

Boletín oficial de la provincia de Cáceres: Número 173 - 1948 Agosto 03

O efeito da idade, sexo e tempo de exposição de machos e fêmeas de Anastrepha fraterculus (Wied.) à toxicidade do fentiom foi avaliado. A idade das moscas mostrou ser importante para o aparecimento dos primeiros sintomas de intoxicação; machos e fêmeas no pico reprodutivo (30 e 60 dias de idade, respectivamente) são menos susceptíveis ao inseticida que moscas nas demais idades (quatro e 120 dias). Não foram detectadas diferenças de toxicidade relacionadas com o peso corporal dos insetos. O TL50, que variou de 3-7 min, mostrou serem os machos menos sensíveis que as fêmeas em todas as idades testadas. Adultos de ambos os sexos, com 30 dias de idade, submetidos a uma exposição contínua e descontínua ao fentiom, não apresentaram efeito toxicológico cumulativo do inseticida. Análises estatísticas sugerem a possivel ocorrência de um mecanismo geral de desintoxicação (quantitativo e/ou qualitativo) relacionado com o sexo, a idade e o tempo de exposição ao fentiom. Como a espécie apresenta alta mobilidade na natureza sugere-se que estas características biológicas e comportamentais sejam consideradas para a obtenção de resultados mais realistas.Effect of age, sex and time exposure of Anastrepha fraterculus (Wied.) to toxicity of fenthion was evaluated. The age of the flies was important to the appearance of the first intoxication symptoms; males and females of reproductive ages (30 and 60 days-old, respectively) were less susceptible to insecticide than flies in the remainder ages (four and 120 days-old). The effect of body weight on insect intoxication was not detected. LT 50 biossay with fenthion (varying from 3-7 minutes) showed a lower susceptibility of males than females at all ages. Adults of both sexes and 30 days-old submitted to continuous and discontinuous exposure to fenthion did not show toxic cumulative effect of the insecticide. The statistical analysis suggests a possible general detoxification mechanism (quantitative and/or qualitative) to fenthion sex-, age- and time-related. Once the species is highly mobile in nature we suggest that in fruit fly toxicological bioassays, these biological traits need to be observed in order to obtain more realistic data

Caracterização bioquímica de esterases de anastrepha fraterculus (diptera : tephritidae)

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Caracterização bioquímica de esterases de anastrepha fraterculus (diptera : tephritidae)

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Genetic components affecting embryonic developmental time of Drosophila melanogaster

The developmental time of the embryonic stage of Drosophila melanogaster was 21.66% faster and 14.75% slower than controls in populations selected for fast and slow developmental speed, respectively. The genetic model with two main loci with dominant and additive effect added to maternal effect and their relevant interactions can explain 96% of the phenotypic variability in the embryonic developmental time according to 14 crossing progenies involving fast and slow flies