Breaking degeneracy in jet dynamics: multi-epoch joint modelling of the BL Lac PKS 2155-304

Supermassive black holes can launch powerful jets which can be some of the most luminous multi-wavelength sources; decades after their discovery their physics and energetics are still poorly understood. The past decade has seen a dramatic improvement in the quality of available data, but despite this improvement the semi-analytical modelling of jets has advanced slowly: simple one-zone models are still the most commonly employed method of interpreting data, in particular for AGN jets. These models can roughly constrain the properties of jets but they cannot unambiguously couple their emission to the launching regions and internal dynamics, which can be probed with simulations. However, simulations are not easily comparable to observations because they cannot yet self-consistently predict spectra. We present an advanced semi-analytical model which accounts for the dynamics of the whole jet, starting from a simplified parametrization of Relativistic Magnetohydrodynamics in which the magnetic flux is converted into bulk kinetic energy. To benchmark the model we fit six quasisimultaneous, multi-wavelength spectral energy distributions of the BL Lac PKS 2155-304 obtained by the TANAMI program, and we address the degeneracies inherent to such a complex model by employing a state-of-the-art exploration of parameter space, which so far has been mostly neglected in the study of AGN jets. We find that this new approach is much more effective than a single-epoch fit in providing meaningful constraints on model parameters.Comment: Accepted for publication on MNRA

The jet-disk symbiosis without maximal jets: 1-D hydrodynamical jets revisited

In this work we discuss the recent criticism by Zdziarski of the maximal jet model derived in Falcke & Biermann (1995). We agree with Zdziarski that in general a jet's internal energy is not bounded by its rest-mass energy density. We describe the effects of the mistake on conclusions that have been made using the maximal jet model and show when a maximal jet is an appropriate assumption. The maximal jet model was used to derive a 1-D hydrodynamical model of jets in agnjet, a model that does multiwavelength fitting of quiescent/hard state X-ray binaries and low-luminosity active galactic nuclei. We correct algebraic mistakes made in the derivation of the 1-D Euler equation and relax the maximal jet assumption. We show that the corrections cause minor differences as long as the jet has a small opening angle and a small terminal Lorentz factor. We find that the major conclusion from the maximal jet model, the jet-disk symbiosis, can be generally applied to astrophysical jets. We also show that isothermal jets are required to match the flat radio spectra seen in low-luminosity X-ray binaries and active galactic nuclei, in agreement with other works.Comment: 7 pages, accepted by A&

Effects on Breathing of Agonists to μ-opioid or GABA\u3csub\u3eA\u3c/sub\u3e Receptors Dialyzed into the Ventral Respiratory Column of Awake and Sleeping Goats

Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neuromodulatory compensation. Herein, we studied neuromodulatory compensation during dialysis of agonists to inhibitory G protein-coupled or ionotropic receptors into the VRC. Microtubules were implanted into the VRC of goats for dialysis of mCSF mixed with agonists to either μ-opioid (DAMGO) or GABAA (muscimol) receptors. We found: (1) V̇I decreased during unilateral but increased during bilateral dialysis of DAMGO, (2) dialyses of DAMGO destabilized breathing, (3) unilateral dialysis of muscimol increased V̇I, and (4) dialysis of DAMGO decreased GABA in the effluent mCSF. We conclude: (1) neuromodulatory compensation can occur during altered inhibitory neuromodulator receptor activity, and (2) the mechanism of compensation differs between G protein-coupled excitatory and inhibitory receptors and between G protein-coupled and inotropic inhibitory receptors

State-Dependent and -Independent Effects of Dialyzing Excitatory Neuromodulator Receptor Antagonists into the Ventral Respiratory Column

Unilateral dialysis of the broad-spectrum muscarinic receptor antagonist atropine (50 mM) into the ventral respiratory column [(VRC) including the pre-Bötzinger complex region] of awake goats increased pulmonary ventilation (V̇i) and breathing frequency (f), conceivably due to local compensatory increases in serotonin (5-HT) and substance P (SP) measured in effluent mock cerebral spinal fluid (mCSF). In contrast, unilateral dialysis of a triple cocktail of antagonists to muscarinic (atropine; 5 mM), neurokinin-1, and 5-HT receptors does not alter V̇i or f, but increases local SP. Herein, we tested hypotheses that 1) local compensatory 5-HT and SP responses to 50 mM atropine dialyzed into the VRC of goats will not differ between anesthetized and awake states; and 2) bilateral dialysis of the triple cocktail of antagonists into the VRC of awake goats will not alter V̇i or f, but will increase local excitatory neuromodulators. Through microtubules implanted into the VRC of goats, probes were inserted to dialyze mCSF alone (time control), 50 mM atropine, or the triple cocktail of antagonists. We found 1) equivalent increases in local 5-HT and SP with 50 mM atropine dialysis during wakefulness compared with isoflurane anesthesia, but V̇i and f only increased while awake; and 2) dialyses of the triple cocktail of antagonists increased V̇i, f, 5-HT, and SP

The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastro-oesopohageal cancer

It remains unclear whether any aspect of quality of life has a role in predicting survival in an unselected cohort of patients with gastro-oesophageal cancer. Therefore the aim of the present study was to examine the relationship between quality of life (EORTC QLQ-C30), clinico-pathological characteristics and survival in patients with gastro-oesophageal cancer. Patients presenting with gastric or oesophageal cancer, staged using the UICC tumour node metastasis (TNM) classification and who received either potentially curative surgery or palliative treatment between November 1997 and December 2002 (n=152) participated in a quality of life study, using the EORTC QLQ-C30 core questionnaire. On univariate analysis, age (P < 0.01), tumour length (P < 0.0001), TNM stage (P<0.0001), weight loss (P<0.0001), dysphagia score (P<0.001), performance status (P<0.1) and treatment (P<0.0001) were significantly associated with cancer-specific survival. EORTC QLQ-C30, physical functioning (P<0.0001), role functioning (P<0.001), cognitive functioning (P<0.01), social functioning (P<0.0001), global quality of life (P<0.0001), fatigue (P<0.0001), nausea/vomiting (P<0.01), pain (P<0.001), dyspnoea (P<0.0001), appetite loss (P<0.0001) and constipation (P<0.05) were also significantly associated with cancer-specific survival. On multivariate survival analysis, tumour stage (P<0.0001), treatment (P<0.001) and appetite loss (P<0.0001) were significant independent predictors of cancer-specific survival. The present study highlights the importance of quality of life (EORTC QLQ-C30) measures, in particular appetite loss, as a prognostic factor in these patients

Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer

There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients with advanced cancer. The aim of the present study was to examine whether an inflammation-based prognostic score (Glasgow Prognostic score, GPS) was associated with survival, in patients with inoperable gastro-oesophageal cancer. Patients diagnosed with inoperable gastro-oesophageal carcinoma and who had measurement of albumin and C-reactive protein concentrations, at the time of diagnosis, were studied (n=258). Clinical information was obtained from a gastro-oesophageal cancer database and analysis of the case notes. Patients with both an elevated C-reactive protein (>10 mg l−1) and hypoalbuminaemia (<35 g l−1) were allocated a GPS score of 2. Patients in whom only one of these biochemical abnormalities was present were allocated a GPS score of 1, and patients with a normal C-reactive protein and albumin were allocated a score of 0. On multivariate survival analysis, age (hazard ratio (HR) 1.22, 95% CI 1.02–1.46, P<0.05), stage (HR 1.55, 95% CI 1.30–1.83, P<0.001), the GPS (HR 1.51, 95% CI 1.22–1.86, P<0.001) and treatment (HR 2.53, 95% CI 1.80–3.56, P<0.001) were significant independent predictors of cancer survival. A 12-month cancer-specific survival in patients with stage I/II disease receiving active treatment was 67 and 60% for a GPS of 0 and 1, respectively. For stage III/IV disease, 12 months cancer-specific survival was 57, 25 and 12% for a GPS of 0, 1 and 2, respectively. In the present study, the GPS predicted cancer-specific survival, independent of stage and treatment received, in patients with inoperable gastro-oesophageal cancer. Moreover, the GPS may be used in combination with conventional staging techniques to improve the prediction of survival in patients with inoperable gastro-oesophageal cancer

Combining timing characteristics with physical broad-band spectral modelling of black hole X-ray binary GX 339–4

GX 339–4 is a black hole X-ray binary that is a key focus of accretion studies, since it goes into outburst roughly every 2–3 yr. Tracking of its radio, infrared (IR), and X-ray flux during multiple outbursts reveals tight broad-band correlations. The radio emission originates in a compact, self-absorbed jet; however, the origin of the X-ray emission is still debated: jet base or corona? We fit 20 quasi-simultaneous radio, IR, optical, and X-ray observations of GX 339–4 covering three separate outbursts in 2005, 2007, 2010–2011, with a composite corona+jet model, where inverse Compton emission from both regions contributes to the X-ray emission. Using a recently proposed identifier of the X-ray variability properties known as power-spectral hue, we attempt to explain both the spectral and evolving timing characteristics, with the model. We find the X-ray spectra are best fit by inverse Compton scattering in a dominant hot corona (kT_e ∼ hundreds of keV). However, radio and IR-optical constraints imply a non-negligible contribution from inverse Compton scattering off hotter electrons (kT_e ≥ 511 keV) in the base of the jets, ranging from a few up to ∼50 per cent of the integrated 3–100 keV flux. We also find that the physical properties of the jet show interesting correlations with the shape of the broad-band X-ray variability of the source, posing intriguing suggestions for the connection between the jet and corona

Combining timing characteristics with physical broad-band spectral modelling of black hole X-ray binary GX 339-4

GX 339-4 is a black hole X-ray binary that is a key focus of accretion studies, since it goes into outburst roughly every 2-3 yr. Tracking of its radio, infrared (IR), and X-ray flux during multiple outbursts reveals tight broad-band correlations. The radio emission originates in a compact, self-absorbed jet; however, the origin of the X-ray emission is still debated: jet base or corona? We fit 20 quasi-simultaneous radio, IR, optical, and X-ray observations of GX 339-4 covering three separate outbursts in 2005, 2007, 2010-2011, with a composite corona+jet model, where inverse Compton emission from both regions contributes to the X-ray emission. Using a recently proposed identifier of the X-ray variability properties known as power-spectral hue, we attempt to explain both the spectral and evolving timing characteristics, with the model. We find the X-ray spectra are best fit by inverse Compton scattering in a dominant hot corona (kT(e) similar to hundreds of keV). However, radio and IR-optical constraints imply a non-negligible contribution from inverse Compton scattering off hotter electrons (kT(e) &gt;= 511 keV) in the base of the jets, ranging from a few up to similar to 50 per cent of the integrated 3-100 keV flux. We also find that the physical properties of the jet show interesting correlations with the shape of the broad-band X-ray variability of the source, posing intriguing suggestions for the connection between the jet and corona

Bhjet: a public multi-zone, steady state jet + thermal corona spectral model

Accreting black holes are sources of major interest in astronomy, particular those launching jets because of their ability to accelerate particles, and dramatically affect their surrounding environment up to very large distances. The spatial, energy and time scales at which a central active black hole radiates and impacts its environment depend on its mass. The implied scale-invariance of accretion/ejection physics between black hole systems of different central masses has been confirmed by several studies. Therefore, designing a self-consistent theoretical model that can describe such systems, regardless of their mass, is of crucial importance to tackle a variety of astrophysical sources. We present here a new and significantly improved version of a scale invariant, steady-state, multi-zone jet model, which we rename bhjet, resulting from the efforts of our group to advance the modelling of black hole systems. We summarise the model assumptions and basic equations, how they have evolved over time, and the additional features that we have recently introduced. These include additional input electron populations, the extension to cyclotron emission in near-relativistic regime, an improved multiple inverse Compton scattering method, external photon seeds typical of AGN and a magnetically-dominated jet dynamical model as opposed to the pressure-driven jet configuration present in older versions. In this paper, we publicly release the code on Github and, in order to facilitate the user's approach to its many possibilities, showcase a few applications as a tutorial.Comment: 28 pages, 16 figures, accepted for publication on MNRAS, code available at https://github.com/matteolucchini1/BHJet/, updated to the latest version of the manuscrip