Synthesis, characterization and DNA binding studies of [Ruthenium(II)(bpy)2L]2+ where L are derivatives of imidazo[4,5-f]-1,10-phenanthrolines

Three novel ruthenium(II) complexes of the general formula [Ru(II)(bpy)2L]2+ were synthesized, where L = 1,10-phenanthroline derivatives of position 2 imidazole having 3,4-didecyloxy-phenyl (ddip), 3,4-ditetradecyloxy-phenyl (dtip) and 3,4-dihexadecyloxy-phenyl (dhip). All complexes were characterized by elemental analysis, 1H-NMR and ESI-MS. Their photophysical properties have also been studied by UV-visible spectroscopy and fluorescence spectroscopy. The complexes exhibit Ru(II) metal centered emission at approximately 610 nm in acetonitrile solution at room temperature. DNA binding studies were carried out by UV-visible titration, luminescence titration and viscosity studies. The results indicated that [Ru(bpy)2(ddip)]2+ binds to CT-DNA by partial intercalation mode, while [Ru(bpy)2(dtip)]2+ and [Ru(bpy)2(dhip)]2+ bind intercalatively via extended ligands

Crystal structure of a dithiocarbazate diester: E-bis(3-methylbenzyl)-1-(6-methylpyridin-2-yl)ethylidene-carbohydrazonod ithioate, C25H27N3S2

C25H27N3S2, monoclinic, P2(1)/n (no. 14), a = 8.2943(4) angstrom, b = 8.5039(4) angstrom, c = 33.587(2) angstrom, beta = 95.921(4)degrees, V = 2356.4 angstrom(3), Z = 4, R-gt(F) = 0.0451, wR(ref)(F-2) = 0.1340, T = 150 K

Crystal structure of 5-methyl ß-N-(methylacetyl)methylenedithiocarbazate, C6H10N2OS2

C 6HION2OS2, monoclinic, P\2\tn\ (No. 14), a = 4.2699(1) Ä, b= 13.7544(2) Ä, c = 15.8280(4) Ä, β = 97.263(1)°, V = 922.1 Ä3 , Ζ = 4, R(F) = 0.063, wR^F2 ) = 0.173, Γ =29 3 Κ

Synthesis, characterization and biological studies of S-4-methylbenzyl-β-N-(2-furylmethylene)dithiocarbazate (S4MFuH) its Zn2+, Cu2+, Cd2+ and Ni2+ complexes

S-4-methylbenzyl-β-N-(2-furylmethylene)dithiocarbazate (S4MFuH, 1) derived from the condensation reaction of furaldehyde (Fu) with S-4-methylbenzyldithiocarbazate (S4MBDTC) has been complexed with transition metal acetates to give Zn(S4MFu)2 (2), Cd(S4MFu)2 (3), Cu(S4MFu)2 (4) and Ni(S4MFu)2 (5). It is evident from the shift in ν(C=N) and ν(N-N) in the IR spectra of the complexes that deprotonated 1 acts as a bidentate ligand coordinating through the azomethine nitrogen and thiolato sulfur atoms. This was confirmed by single crystal X-ray diffractometry. The U-shaped dithiocarbazate 1 exists in the E configuration with the thione bond anti to the azo bond. A change in conformation is noted in the transition metal complexes resulting from deprotonation and N-S-chelation. 2 and 3 display a distorted tetrahedral geometry with the major cause of the distortion being two close intramolecular M...O interactions. Binding interaction studies with calf thymus DNA demonstrated that 4 also had the strongest DNA binding affinity (Kb = 2.85 × 104 M-1) among all compounds prepared in this work. The Cu(II) complex, 4, was also moderately active against estrogen receptor-positive breast cancer cells, MCF-7 (IC50 = 3.02 μM) while the remainder were inactive against MCF-7 and all showed no activity towards receptor negative breast cancer cells, MDA-MB-231

Studies on coordination chemistry and biological activities of a nitrogen-sulfur donor ligand with lighter and heavier metal ions

Consiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7 Rome / CNR - Consiglio Nazionale delle RichercheSIGLEITItal