31 research outputs found
Method for promoting ovulation, parturition, and lactation in mammals
The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D.sub.2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D.sub.2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D.sub.2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster
Method for promoting ovulation, parturition, and lactation in mammals
The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D.sub.2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D.sub.2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D.sub.2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster
Laminitis in horses
The present invention generally relates to various methods for treating the laminitis syndrome in animals. These benefits are obtained by administering to the animals a composition containing an .alpha.-adrenergic antagonist that does not substantially cross the blood brain barrier. In one embodiment, the .alpha.-adrenergic antagonist is domperidone. The domperidone can be administered to the animal either orally, subcutaneously, or intramuscularly and can be used to treat animals suffering from symptoms of laminitis
Method of treating fescue toxicosis with domperidone
A novel method for using domperidone, a dopamine receptor antagonist, for treating fescue toxicosis in animals is provided. Fescue toxicosis is caused by animals grazing on endophyte-infected fescue grass. Treatment of the animal with various dosages of domperidone results in effective management of the toxin. The domperidone treatments do not cause any substantial adverse behavioral or neurological side effects in the animal. Domperidone is a more effective treatment for fescue toxicosis than previously-known agents such a metoclopramide and sulpiride
Multiple Front Propagation Into Unstable States
The dynamics of transient patterns formed by front propagation in extended
nonequilibrium systems is considered. Under certain circumstances, the state
left behind a front propagating into an unstable homogeneous state can be an
unstable periodic pattern. It is found by a numerical solution of a model of
the Fr\'eedericksz transition in nematic liquid crystals that the mechanism of
decay of such periodic unstable states is the propagation of a second front
which replaces the unstable pattern by a another unstable periodic state with
larger wavelength. The speed of this second front and the periodicity of the
new state are analytically calculated with a generalization of the marginal
stability formalism suited to the study of front propagation into periodic
unstable states. PACS: 47.20.Ky, 03.40.Kf, 47.54.+rComment: 12 page
Pattern selection as a nonlinear eigenvalue problem
A unique pattern selection in the absolutely unstable regime of driven,
nonlinear, open-flow systems is reviewed. It has recently been found in
numerical simulations of propagating vortex structures occuring in
Taylor-Couette and Rayleigh-Benard systems subject to an externally imposed
through-flow. Unlike the stationary patterns in systems without through-flow
the spatiotemporal structures of propagating vortices are independent of
parameter history, initial conditions, and system length. They do, however,
depend on the boundary conditions in addition to the driving rate and the
through-flow rate. Our analysis of the Ginzburg-Landau amplitude equation
elucidates how the pattern selection can be described by a nonlinear eigenvalue
problem with the frequency being the eigenvalue. Approaching the border between
absolute and convective instability the eigenvalue problem becomes effectively
linear and the selection mechanism approaches that of linear front propagation.
PACS: 47.54.+r,47.20.Ky,47.32.-y,47.20.FtComment: 18 pages in Postsript format including 5 figures, to appear in:
Lecture Notes in Physics, "Nonlinear Physics of Complex Sytems -- Current
Status and Future Trends", Eds. J. Parisi, S. C. Mueller, and W. Zimmermann
(Springer, Berlin, 1996
Formation of Liesegang patterns: A spinodal decomposition scenario
Spinodal decomposition in the presence of a moving particle source is
proposed as a mechanism for the formation of Liesegang bands. This mechanism
yields a sequence of band positions x_n that obeys the spacing law
x_n~Q(1+p)^n. The dependence of the parameters p and Q on the initial
concentration of the reagents is determined and we find that the functional
form of p is in agreement with the experimentally observed Matalon-Packter law.Comment: RevTex, 4 pages, 4 eps figure
Pearling and Pinching: Propagation of Rayleigh Instabilities
A new category of front propagation problems is proposed in which a spreading
instability evolves through a singular configuration before saturating. We
examine the nature of this front for the viscous Rayleigh instability of a
column of one fluid immersed in another, using the marginal stability criterion
to estimate the front velocity, front width, and the selected wavelength in
terms of the surface tension and viscosity contrast. Experiments are suggested
on systems that may display this phenomenon, including droplets elongated in
extensional flows, capillary bridges, liquid crystal tethers, and viscoelastic
fluids. The related problem of propagation in Rayleigh-like systems that do not
fission is also considered.Comment: Revtex, 7 pages, 4 ps figs, PR
Localization-delocalization transition of a reaction-diffusion front near a semipermeable wall
The A+B --> C reaction-diffusion process is studied in a system where the
reagents are separated by a semipermeable wall. We use reaction-diffusion
equations to describe the process and to derive a scaling description for the
long-time behavior of the reaction front. Furthermore, we show that a critical
localization-delocalization transition takes place as a control parameter which
depends on the initial densities and on the diffusion constants is varied. The
transition is between a reaction front of finite width that is localized at the
wall and a front which is detached and moves away from the wall. At the
critical point, the reaction front remains at the wall but its width diverges
with time [as t^(1/6) in mean-field approximation].Comment: 7 pages, PS fil
Fluctuating "Pulled" Fronts: the Origin and the Effects of a Finite Particle Cutoff
Recently it has been shown that when an equation that allows so-called pulled
fronts in the mean-field limit is modelled with a stochastic model with a
finite number of particles per correlation volume, the convergence to the
speed for is extremely slow -- going only as .
In this paper, we study the front propagation in a simple stochastic lattice
model. A detailed analysis of the microscopic picture of the front dynamics
shows that for the description of the far tip of the front, one has to abandon
the idea of a uniformly translating front solution. The lattice and finite
particle effects lead to a ``stop-and-go'' type dynamics at the far tip of the
front, while the average front behind it ``crosses over'' to a uniformly
translating solution. In this formulation, the effect of stochasticity on the
asymptotic front speed is coded in the probability distribution of the times
required for the advancement of the ``foremost bin''. We derive expressions of
these probability distributions by matching the solution of the far tip with
the uniformly translating solution behind. This matching includes various
correlation effects in a mean-field type approximation. Our results for the
probability distributions compare well to the results of stochastic numerical
simulations. This approach also allows us to deal with much smaller values of
than it is required to have the asymptotics to be valid.Comment: 26 pages, 11 figures, to appear in Phys. rev.