Propagation and stability of optical pulses in a diffractive dispersive non-linear medium

Propagation and stability of light pulses under the combined influence of the optical Kerr effect, dispersion and diffraction are investigated by adopting a variational procedure. In particular, it is found that 'light bullets', i.e. radially symmetric pulses propagating without distortion, are not necessarily unstable under perturbations which do not maintain radial symmetry

Built-in reduction of statistical fluctuations of partitioning objects

Our theoretical and numerical investigation of the movement of an object that partitions a microtubule filled with small particles indicates that vibrations warranted by thermal equilibrium are reached only after a time that increases exponentially with the number of particles involved. This points to a basic mechanical process capable of breaching, on accessible time scales, the ultimate ergodic constraints that force randomness on bound microscale and nanoscale systems

Coherence and Efficiency in Nonlinear Optical Processes

A remarkable difference between linear and nonlinear processes lies in the fact that the efficiency of the latter depends on the coherence properties of the electromagnetic field (pump) from which the process is driven

Azimuthally polarized spatial dark solitons: exact solutions of Maxwell's equations in a Kerr medium

Spatial Kerr solitons, typically associated with the standard paraxial nonlinear Schroedinger equation, are shown to exist to all nonparaxial orders, as exact solutions of Maxwell's equations in the presence of vectorial Kerr effect. More precisely, we prove the existence of azimuthally polarized, spatial, dark soliton solutions of Maxwell's equations, while exact linearly polarized (2+1)-D solitons do not exist. Our ab initio approach predicts the existence of dark solitons up to an upper value of the maximum field amplitude, corresponding to a minimum soliton width of about one fourth of the wavelength.Comment: 4 pages, 4 figure

Quantum temporal correlations and entanglement via adiabatic control of vector solitons

It is shown that optical pulses with a mean position accuracy beyond the standard quantum limit can be produced by adiabatically expanding an optical vector soliton followed by classical dispersion management. The proposed scheme is also capable of entangling positions of optical pulses and can potentially be used for general continuous-variable quantum information processing.Comment: 5 pages, 1 figure, v2: accepted by Physical Review Letters, v3: minor editing and shortening, v4: included the submitted erratu

Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort : a nested case-control study

Background and aims: The increase in breast cancer incidence over recent decades has been accompanied by an increase in the frequency of metabolic syndrome. Several studies suggest that breast cancer risk is associated with the components of metabolic syndrome (high serum glucose and triglycerides, low HDL-cholesterol, high blood pressure, and abdominal obesity), but no prospective study has investigated risk in relation to the presence of explicitly defined metabolic syndrome. We investigated associations between metabolic syndrome, its components, and breast cancer risk in a nested case-control study on postmenopausal women of the ORDET cohort. Methods and results: After a median follow-up of 13.5 years, 163 women developed breast cancer; metabolic syndrome was present in 29.8%. Four matched controls per case were selected by incidence density sampling, and rate ratios were estimated by conditional logistic regression. Metabolic syndrome (i.e. presence of three or more metabolic syndrome components) was significantly associated with breast cancer risk (rate ratio 1.58 [95% confidence interval 1.07-2.33]), with a significant risk increase for increasing number of components (P for trend 0.004). Among individual metabolic syndrome components, only low serum HDL-cholesterol and high triglycerides were significantly associated with increased risk. Conclusions: This prospective study indicates that metabolic syndrome is an important risk factor for breast cancer in postmenopausal women. Although serum HDL-cholesterol and triglycerides had the strongest association with breast cancer, all components may contribute to increased risk by multiple interacting mechanisms. Prevention or reversal of metabolic syndrome by life-style changes may be effective in preventing breast cancer in postmenopausal women

Analysis of peripheral blood dendritic cells as a non-invasive tool in the follow-up of patients with chronic hepatitis C

Hepatitis C virus (HCV) has a high propensity to establish chronic infections. Failure of HCV-infected individuals to activate effective antiviral immune responses is at least in part related to HCV-induced impairment of dendritic cells (DCs) that play a central role in activating T cell responses. Although the impact of HCV on DC phenotype and function is likely to be more prominent in the liver, major HCV-induced alterations are detectable in peripheral blood DCs (pbDCs) that represent the most accessible source of DCs. These alterations include numerical reduction, impaired production of inflammatory cytokines and increased production of immunosuppressive IL10. These changes in DCs are relevant to our understanding the immune mechanisms underlying the propensity of HCV to establish persistent infection. Importantly, the non-invasive accessibility of pbDCs renders the analysis of these cells a convenient procedure that can be serially repeated in patient follow-up. Accordingly, the study of pbDCs in HCV-infected patients during conventional treatment with pegylated interferon and ribavirin indicated that restoration of normal plasmacytoid DC count may represent an additional mechanism contributing to the efficacy of the dual therapy. It also identified the pre-treatment levels of plasmacytoid DCs and IL10 as putative predictors of response to therapy. Treatment of chronic HCV infection is changing, as new generation direct-acting antiviral agents will soon be available for use in interferon-free therapeutic strategies. The phenotypic and functional analysis of pbDCs in this novel therapeutic setting will provide a valuable tool for investigating mechanisms underlying treatment efficacy and for identifying predictors of treatment response