Relic Neutrinos and Z-Resonance Mechanism for Highest-Energy Cosmic Rays

The origin of the highest-energy cosmic rays remains elusive. The decay of a superheavy particle (X) into an ultra-energetic neutrino which scatters from a relic (anti-)neutrino at the Z-resonance has attractive features. Given the necessary X mass of $10^{14\sim15}$ GeV, the required lifetime, $10^{15\sim16}$ y, renders model-building a serious challenge but three logical possibilities are considered: (i) X is a Higgs scalar in SU(15) belonging to high-rank representation, leading to {\it power}-enhanced lifetime; (ii) a global X quantum number has {\it exponentially}-suppressed symmetry-breaking by instantons; and (iii) with additional space dimension(s) localisation of X within the real-world brane leads to {\it gaussian} decay suppression, the most efficient of the suppression mechanisms considered.Comment: 10 page LaTeX and one postscript figure. References adde

Conformal Transformations and Accelerated Cosmologies

A cosmological theory that predicts a late-time accelerated attractor with a constant dark matter to dark energy ratio can be said to solve the Coincidence Problem. Such cosmologies are naturally generated in the context of non-standard gravity theories under conformal transformation because of the resulting couplings between scalar fields and matter. The present work examines four classes of these transformed theories and finds that only a small subset--those with a single scalar field--are capable of solving the Coincidence Problem.Comment: 27 pages LaTe

CMB with Quintessence: Analytic Approach and CMBFAST

A particular kind of quintessence is considered, with equation of motion $p_Q/\rho_Q = -1$, corresponding to a cosmological term with time-dependence $\Lambda(t) = \Lambda(t_0) (R(t_0)/R(t))^{P}$ which we examine initially for $0 \leq P < 3$. Energy conservation is imposed, as is consistency with big-bang nucleosynthesis, and the range of allowed $P$ is thereby much restricted to $0 \leq P < 0.2$. The position of the first Doppler peak is computed analytically and the result combined with analysis of high-Z supernovae to find how values of $\Omega_m$ and $\Omega_{\Lambda}$ depend on $P$. Some comparison is made to the CMBFAST public code.Comment: 13 pp LaTeX and 7 postscript figure

Increasing the Spatial Coverage of Atmospheric Aerosol Depth Measurements Using Random Forest and Mean Filters

Aerosols play a critical role in atmospheric chemistry, and affect clouds, climate, and human health. However, the spatial coverage of satellite-derived aerosol optical depth (AOD) products is limited by cloud cover, orbit patterns, polar night, snow, and bright surfaces, which negatively impacts the coverage and accuracy of particulate matter modeling and health studies relying on air pollution characterization. We present a random forest model trained to capture spatial dependence of AOD and produce higher coverage through imputation. By combining the models with and without the mean filters, we are able to create full-coverage high-resolution daily AOD in the conterminous U.S., which can be used for aerosol estimation and other studies leveraging air pollutant concentration levels.Comment: IEEE International Geoscience and Remote Sensing Symposium 2023 6 Pages, 2 Figure

Writings: Transcript - A Bold New Revolution: Jacksonville Before Consolidation

Speeches: A transcription of A Bold New Revolution: Jacksonville Before Consolidation - A Panel Discussion Commemorating 38 Years of Consolidated Government October 21, 2006

The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution

CD4+ and CD8+ αβ T cell antigen recognition is determined by the interaction between the TCR Complementarity Determining Region (CDR) loops and the peptide-presenting MHC complex. These T cells are known for their ability to recognize multiple pMHC complexes, and for a necessary promiscuity that is required for their selection and function in the periphery. Crystallographic studies have previously elucidated the role of structural interactions in TCR engagement, but our understanding of the dynamic process that occurs during TCR binding is limited. To better understand the dynamic states that exist for TCR CDR loops in solution, and how this relates to their states when in complex with pMHC, we simulated the 2C T cell receptor in solution using all-atom molecular dynamics in explicit water and constructed a Markov State Model for each of the CDR3α and CDR3β loops. These models reveal multiple metastable states for the CDR3 loops in solution. Simulation data and metastable states reproduce known CDR3β crystal conformations, and reveal several novel conformations suggesting that CDR3β bound states are the result of search processes from nearby pre-existing equilibrium conformational states. Similar simulations of the invariant, Type I Natural Killer T cell receptor NKT15, which engages the monomorphic, MHC-like CD1d ligand, demonstrate that iNKT TCRs also have distinct states, but comparatively restricted degrees of motion

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 envelope glycoprotein trimers on neutralizing antibody induction

Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to improve nAb responses by removing the N362 glycan that also lines the CD4bs. All 4 rabbits developed nAbs. One targeted the N197 glycan hole like our previous sera. Two sera depended on the N463 glycan, again suggesting CD4bs overlap. Heterologous boosts appeared to reduce nAb clashes with the N362 glycan. The fourth serum targeted a N362 glycan-sensitive epitope. VLP manufacture challenges prevented us from immunizing larger rabbit numbers to empower a robust statistical analysis. Nevertheless, trends suggest that targeted glycan removal may improve nAb induction by exposing new epitopes and that it may be possible to modify nAb speciUcity using rational heterologous boosts

Extreme precipitation and emergency room visits for influenza in Massachusetts: a case-crossover analysis

Abstract Background Influenza peaks during the wintertime in temperate regions and during the annual rainy season in tropical regions – however reasons for the observed differences in disease ecology are poorly understood. We hypothesize that episodes of extreme precipitation also result in increased influenza in the Northeastern United States, but this association is not readily apparent, as no defined ‘rainy season’ occurs. Our objective was to evaluate the association between extreme precipitation (≥ 99th percentile) events and risk of emergency room (ER) visit for influenza in Massachusetts during 2002–2008. Methods A case-crossover analysis of extreme precipitation events and influenza ER visits was conducted using hospital administrative data including patient town of residence, date of visit, age, sex, and associated diagnostic codes. Daily precipitation estimates were generated for each town based upon data from the National Oceanic and Atmospheric Administration. Odds ratio (OR) and 95% confidence intervals (CI) for associations between extreme precipitation and ER visits for influenza were estimated using conditional logistic regression. Results Extreme precipitation events were associated with an OR = 1.23 (95%CI: 1.16, 1.30) for ER visits for influenza at lag days 0–6. There was significant effect modification by race, with the strongest association observed among Blacks (OR = 1.48 (1.30, 1.68)). Conclusions We observed a positive association between extreme precipitation events and ER visits for influenza, particularly among Blacks. Our results suggest that influenza is associated with extreme precipitation in a temperate area; this association could be a result of disease ecology, behavioral changes such as indoor crowding, or both. Extreme precipitation events are expected to increase in the Northeastern United States as climate change progresses. Additional research exploring the basis of this association can inform potential interventions for extreme weather events and influenza transmission

Cosmic Degeneracy with Dark Energy Equation of State

We discuss a degeneracy between the geometry of the universe and the dark energy equation of state $w_{\rm X}$ which exists in the power spectrum of the cosmic microwave background. In particular, for the case with $w_{\rm X} < -1$, this degeneracy has interesting implications to a lower bound on $w_{\rm X}$ from observations. It is also discussed how this degeneracy can be removed using current observations of type Ia supernovae.Comment: 13 pages LaTeX with five [one new] eps figure