Reciprocal Inhibition Post-stroke is Related to Reflex Excitability and Movement Ability

Objective Decreased reciprocal inhibition (RI) of motor neurons may contribute to spasticity after stroke. However, decreased RI is not a uniform observation among stroke survivors, suggesting that this spinal circuit may be influenced by other stroke-related characteristics. The purpose of this study was to measure RI post-stroke and to examine the relationship between RI and other features of stroke. Methods RI was examined in 15 stroke survivors (PAR) and 10 control subjects by quantifying the effect of peroneal nerve stimulation on soleus H-reflex amplitude. The relationship between RI and age, time post-stroke, lesion side, walking velocity, Fugl-Meyer, Ashworth, and Achilles reflex scores was examined. Results RI was absent and replaced by reciprocal facilitation in 10 of 15 PAR individuals. Reciprocal facilitation was associated with low Fugl-Meyer scores and slow walking velocities but not with hyperactive Achilles tendon reflexes. There was no relationship between RI or reciprocal facilitation and time post-stroke, lesion side, or Ashworth score. Conclusions Decreased RI is not a uniform finding post-stroke and is more closely related to walking ability and movement impairment than to spasticity. Significance Phenomena other than decreased RI may contribute to post-stroke spasticity

New venture internationalisation and the cluster life cycle: insights from Ireland’s indigenous software industry

The internationalization of new and small firms has been a long-standing concern of researchers in international business (Coviello and McAuley, 1999; Ruzzier et al., 2006). This topic has been re-invigorated over the last decade by the burgeoning literature on so-called ‘born globals’ (BG) or ‘international new ventures’ (INV) – businesses that confound the expectations of traditional theory by being active internationally at, or soon after, inception (Aspelund et al., 2007; Bell, 1995; Rialp et al., 2005). Until quite recently, this literature had not really considered how the home regional environment of a new venture might influence its internationalization behaviour. However, a handful of recent studies have shown that being founded in a geographic industry ‘cluster’ can positively influence the likelihood of a new venture internationalizing (e.g., Fernhaber et al., 2008; Libaers and Meyer, 2011). This chapter seeks to build on these recent contributions by further probing the relationship between clusters and new venture internationalization. Specifically, taking inspiration from recent work in the thematic research stream on clusters (which spans the fields of economic geography, regional studies and industrial dynamics), the chapter explores how the emergence and internationalization of new ventures might be affected by the ‘cluster life cycle’ context within which they are founded. This issue is examined through a revelatory longitudinal case study of Ireland’s indigenous software cluster. The study investigates the origins and internationalization behaviour of ‘leading’ Irish software ventures but, in contrast to many existing studies, it seeks to understand these firms within the context of the Irish software cluster’s emergence and evolution through a number of ‘life-cycle’ stages

From Sawney Beane to Sweeney Todd: Murder machines in the mid-nineteenth century metropolis

This article traces the changes and continuities in fictional stories of serial murder in London from the late-seventeenth century to the mid-nineteenth century. In particular, it shows how changes in the primary audience for metropolitan popular culture necessitated dramatic shifts in the tale of serial killing and narratives of violence. Thus, by the nineteenth century, as the lower classes had become the main supporters of both traditional and new genres of entertainment in popular culture, their experience of and fears and anxieties about urban change became intertwined with myths about serial killing and reflected in a new character of the public nightmare, Sweeney Todd, the barber of Fleet Street, who set out to effectively depopulate the capital with his ghastly murder machine

House prices and the quality of public schools: what are we buying?

Do house prices reflect the quality of the local public schools? To what extent do school district policies determine how well students perform? How do such factors as neighborhood, family, and peers affect school quality and house prices? Ted Crone examines these questions, and others, to determine whether house prices do, indeed, include a school premium.Education ; Housing

An alternative definition of economic regions in the U.S. based on similarities in state business cycles

Since the 1950s the Bureau of Economic analysis (BEA) has grouped the states into eight regions based primarily on cross-sectional similarities in their socioeconomic characteristics. This is the most frequently used grouping of states in the U.S. for economic analysis. Since several recent studies concentrate on similarities and differences in regional business cycles, this paper groups states into regions based not on a broad set of socioeconomic characteristics but on the similarities in their business cycles. The analysis makes use of a consistent set of coincident indexes estimated from a Stock and Watson-type model. The author applies k-means cluster analysis to the cyclical components of these indexes to group the 48 contiguous states into eight regions with similar cycles. Having grouped the states into regions, the author determines the relative strength of cohesion among the states in the various regions. Finally, the author compares the regions defined in this paper with the BEA regions.Business cycles ; Regional economics

Where have all the factory jobs gone - and why?

Over the past 30 years, the three states of the Third Federal Reserve District have lost more than one-third of their manufacturing jobs. And that job loss has accelerated over the past 15 years. Despite this, the region's manufacturing output has expanded over the same period, although much more slowly than the nation's. Why has the region's manufacturing sector lagged behind? In this article, Ted Crone looks at shifts in markets and differences in costs as possible culprits.Employment (Economic theory) ; Federal Reserve District, 3rd ; Manufactures

The changing faces of the Third District: a snapshot of the region from the 2000 census.

In "The Changing Faces of the Third District: A Snapshot of the Region from the 2000 Census," Ted Crone describes some of these patterns and tells us what they mean for economic growth in this region.Federal Reserve District, 3rd ; Population

The long and the short of it: recent trends and cycles in the Third District states

Most discussions of business cycles focus on the national economy. But regional cycles are also important, and they can vary significantly from one region to another. Analysis of regional cycles can help businesses plan investments and project sales, among other things. A look at the economies of the Third District states - Pennsylvania, New Jersey, and Delaware -illustrates how trends and cycles can differ even among neighboring states. In "The Long and the Short of It: Recent Trends and Cycles in the Third District States," Ted Crone traces the historical patterns of the three states' economies but warns that noting such patterns is not a substitute for detailed current analysis.Business cycles

A new look at economic indexes for the states in the Third District

If we want to know how things are going in the economy, which measures should we look at? Unemployment? GDP? Or something else? One solution is to combine several measures into a composite index of current or future economic activity. Several years ago, the Philadelphia Fed did just that for the states in the Third District. Now, a number of factors suggest that revisions of those indexes are in order. This article explains what those revisions entail and why the new indexes are better than the old ones.Federal Reserve District, 3rd