Influence of the Characteristics of the STM-tip on the Electroluminescence Spectra

We analyze the influence of the characteristics of the STM-tip (applied voltage, tip radius) on the electroluminescence spectra from an STM-tip-induced quantum dot taking into account the many-body effects. We find that positions of electroluminescence peaks, attributed to the electron-hole recombination in the quantum dot, are very sensitive to the shape and size of the confinement potential as determined by the tip radius and the applied voltage. A critical value of the tip radius is found, at which the luminescence peak positions as a function of the tip radius manifest a transition from decreasing behavior for smaller radii to increasing behavior for larger radii. We find that this critical value of the tip radius is related to the confinement in the lateral and normal direction.Comment: 15 pages, 5 figure

A Girsanov Result through Birkhoff Integral

A vector-valued version of the Girsanov theorem is presented, for a scalar process with respect to a Banach-valued measure. Previously, a short discussion about the Birkhoff-type integration is outlined, as for example integration by substitution, in order to fix the measure-theoretic tools needed for the main result, Theorem 6, where a martingale equivalent to the underlying vector probability has been obtained in order to represent the modified process as a martingale with the same marginals as the original one

Enhancing Market Readiness for nZEB Implementation

ABSTRACT: Despite transposing the 2010/31/EU Directive's requirements creates legal responsibilities at the national level, the nearly Zero energy building (nZEB) principle does not appear to be widely adopted just yet in many nations. Previous studies have shown that the most significant barriers include determining the cost-effective ideal integration of the technologies appropriate for nZEB and the skills constraints faced by the construction industry. In order to meet the challenge of an efficient nZEB implementation, existing certification courses and training programs are still insufficient and inadequate, and hiring experienced specialists for building retrofit and new construction is not common practice. The traditionally conservative real estate industry is nevertheless hesitant to adopt the new building standards and practices, notably in the residential sector, despite a significant movement towards nZEB and extensive energy renovation. In this specific situation, this paper provides a preliminary analysis of the European project nZEB Ready Enhancing Market Readiness for nZEB Implementation, which aims to address the issue of the effective implementation of the nZEB and make use of new possibilities to act at the market level in order to boost the market's readiness for a successful implementation of the nZEB and to encourage demand for energy-related skills among construction workers and specialists in the countries involved and beyond.info:eu-repo/semantics/publishedVersio

Interaction Properties of the Periodic and Step-like Solutions of the Double-Sine-Gordon Equation

The periodic and step-like solutions of the double-Sine-Gordon equation are investigated, with different initial conditions and for various values of the potential parameter $\epsilon$. We plot energy and force diagrams, as functions of the inter-soliton distance for such solutions. This allows us to consider our system as an interacting many-body system in 1+1 dimension. We therefore plot state diagrams (pressure vs. average density) for step-like as well as periodic solutions. Step-like solutions are shown to behave similarly to their counterparts in the Sine-Gordon system. However, periodic solutions show a fundamentally different behavior as the parameter $\epsilon$ is increased. We show that two distinct phases of periodic solutions exist which exhibit manifestly different behavior. Response functions for these phases are shown to behave differently, joining at an apparent phase transition point.Comment: 17pages, 15 figure

Computer-assisted and patient-specific 3-D planning and evaluation of a single-cut rotational osteotomy for complex long-bone deformities

Malunion after long bone fracture results in an incorrect position of the distal bone segment. This misalignment may lead to reduced function of the limb, early osteoarthritis and chronic pain. An established treatment option is a corrective osteotomy. For complex malunions, a single-cut rotational osteotomy is sometimes preferred in cases of angular deformity in three dimensions. However, planning and performing this type of osteotomy is relatively complex. This report describes a computer-assisted method for 3-D planning and realizing a single-cut rotational osteotomy with a patient-specific cutting guide for orienting the osteotomy and an angled jig for adjusting the rotation angle. The accuracy and reproducibility of the method is evaluated experimentally using plastic bones. In addition, complex rotational deformities are simulated by a computer to investigate the relation between deformity and correction parameters. The computed relation between deformity and correction parameters enables the surgeon to judge the feasibility of a single-cut rotational osteotomy. This appears possible for deformities combining axial misalignment with sufficient axial rotation. The proposed 3-D method of preoperative planning and transfer with a patient-specific cutting guide and angled jig renders the osteotomy procedure easily applicable, accurate, reproducible, and is a good alternative for complex and expensive navigation systems

Secure Opportunistic Multipath Key Exchange

The security of today\u27s widely used communication security protocols is based on trust in Certificate Authorities (CAs). However, the real security of this approach is debatable, since certificate handling is tedious and many recent attacks have undermined the trust in CAs. On the other hand, opportunistic encryption protocols such as Tcpcrypt, which are currently gaining momentum as an alternative to no encryption, have similar security to using untrusted CAs or self-signed certificates: they only protect against passive attackers. In this paper, we present a key exchange protocol, Secure Multipath Key Exchange (SMKEX), that enables all the benefits of opportunistic encryption (no need for trusted third parties or pre-established secrets), as well as proven protection against some classes of active attackers. Furthermore, SMKEX can be easily extended to a trust-on-first-use setting and can be easily integrated with TLS, providing the highest security for opportunistic encryption to date while also increasing the security of standard TLS. We show that SMKEX is made practical by the current availability of path diversity between different AS-es. We also show a method to create path diversity with encrypted tunnels without relying on the network topology. These allow SMKEX to provide protection against most adversaries for a majority of Alexa top 100 web sites. We have implemented SMKEX using a modified Multipath TCP kernel implementation and a user library that overwrites part of the socket API, allowing unmodified applications to take advantage of the security provided by SMKEX

Association of MUTYH and colorectal cancer

Mutations in the MUTYH gene have been reported to be associated with increased risk of developing colorectal cancer. In this study, we confirmed this association using original data on 928 colorectal cancer cases and 845 healthy controls from Scotland. We then conducted a meta-analysis from published data on the association between mutations at MUTYH and colorectal cancer risk. We show for the first time a small but significant mono-allelic effect with a genotype relative risk (GRR) of 1.27 (95% confidence interval (CI): 1.01–1.61), and confirm and give a more precise estimate of the strong bi-allelic effect with an estimated GRR of 117 (95% CI: 74–184). This study underscores the need for large sample sizes in order to identify small gene effects when the disease allele frequency is low

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

Background: defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance risk alleles. We report a large collaborative meta-analysis to assess and refine CRC risk estimates associated with bi-allelic and mono-allelic MUTYH variants and investigate age and sex influence on risk. Methods: MUTYH genotype data were included from 20 565 cases and 15 524 controls. Three logistic regression models were tested: a crude model; adjusted for age and sex; adjusted for age, sex and study. Results: all three models produced very similar results. MUTYH bi-allelic carriers demonstrated a 28-fold increase in risk (95% confidence interval (CI): 6.95-115). Significant bi-allelic effects were also observed for G396D and Y179C/G396D compound heterozygotes and a marginal mono-allelic effect for variant Y179C (odds ratio (OR)=1.34; 95% CI: 1.00-1.80). A pooled meta-analysis of all published and unpublished datasets submitted showed bi-allelic effects for MUTYH, G396D and Y179C (OR=10.8, 95% CI: 5.02-23.2; OR=6.47, 95% CI: 2.33-18.0; OR=3.35, 95% CI: 1.14-9.89) and marginal mono-allelic effect for variants MUTYH (OR=1.16, 95% CI: 1.00-1.34) and Y179C alone (OR=1.34, 95% CI: 1.01-1.77). Conclusions: overall, this large study refines estimates of disease risk associated with mono-allelic and bi-allelic MUTYH carriers