Polyphénols du vin et protection cardiovasculaire chez l'homme : l'évaluation in vitro des indicateurs secondaires de protection doit prendre mieux en compte la concentration réelle des polyphénols in vivo

National audienc

Risk factors for cortical, nuclear, and posterior subcapsular cataracts

International audienc

Age-related macular degeneration and antioxidant status in the POLA study

International audienc

Antioxidant capacity and angiotensin I converting enzyme inhibitory activity of a melon concentrate rich in superoxide dismutase

Antioxidant capacity and Angiotensin 1-converting enzyme (ACE) inhibitory activity of a melon concentrate rich in superoxide dismutase (SOD-MC) were investigated in vitro. The total antioxidant capacity (TAC) was measured by the Trolox equivalent antioxidant capacity assay (TEAC), the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, and the ferric reducing antioxidant power assay (FRAP). The ability of the extract to scavenge three specific reactive oxygen species (superoxide radical anion (O2°-), hydroxyl radical (HO°) and hydrogen peroxide (H2O2)) was also investigated in order to better evaluate its antioxidant properties. Even if the measures of TAC were relatively low, results clearly established an antioxidant potential of SOD-MC that exhibited the highest radical-scavenging activity towards O2°-, with a IC50 12 fold lower than that of H2O2 or HO°. This lets hypothesis that the antioxidant potential of SOD-MC could be mainly due to its high level of SOD. Moreover, for the first time, an ACE inhibitory activity of SOD-MC (IC50 = 2.4 0.1 mg/mL) was demonstrated, showing that its use as a functional food ingredient with potential preventive benefits in the context of hypertension may have important public health implications and should be carefully considered

Protective Effects of HDL against oxidative stress are impaired in hemodialysis patients.

International audienc

Suspicion of latent delta 5-desaturase and peroxisomal beta-oxidation deficiency in elderly women over 75 years of age

International audienc

Protective effects of HDL against oxidative stress are impaired in haemodialysis patients.

International audienc