Estudios de Caso sobre Ciencias Agropecuarias y Rurales en el siglo XXI.

Libro científico sobre estudios de casos en el medio agropecuario y ruralCon el advenimiento del siglo XXI y el avance de los procesos de globalización, el medio rural presenta diversos cambios económicos, sociales, políticos y culturales. Lo anterior significa que el campo es un objeto de estudio altamente dinámico, complejo e inasible. las ciencias agropecuarias y rurales, en la actualidad, requieren de un abordaje sistémico e interdisciplinario que den cuenta de la heterogeneidad de situaciones y contextos que enfrenta el campo mexicano. La presente obra agrupa 18 estudios de caso, que capturan algunas fotografías de las diversas problemáticas de la ruralidad mexicana, con lo cual se pretende dar cuenta tanto de los objetivos de estudio como de la perspectiva teórico metodológico desde que estos son abordados. lo anterior tiene que ver con el hecho de que las ciencias agropecuarias y rurales manifiestan un alto grado de observación empírica, motivo por el que los estudios de caso se convierten en la perspectiva metodológica idónea que permite ir y venir de la realidad a la teoría y viceversa para la construcción de objetos de estudio. En este volumen se aborda una gran diversidad de casos, que sintetizan la heterogeneidad de enfoques y perspectivas mediante las cuales los fenómenos agropecuarios y rurales han sido abordados en el Instituto de Ciencias Agropecuarias y Rurales de la Universidad Autónoma del Estado de México, en los últimos 30 años

Measurement of satisfaction and quality in the service of the Legal Office of the Universidad Libre Seccional Socorro

El proyecto “Medición de la satisfacción y calidad en el servicio del Consultorio Jurídico de la Universidad Libre Seccional Socorro”, desde la perspectiva de sus usuarios, es una investigación que identificó las perspectivas de los usuarios del Consultorio Jurídico de la Universidad Libre Seccional Socorro, en sus sedes de atención una sede en el municipio de Socorro y otra sede en el municipio de San Gil – Santander. La investigación se centró en los usuarios de los municipios cercanos a las dos sedes de atención, Socorro capital de la provincia comunera con catorce (14) municipios como, Confines, Simacota, Palmas de Socorro, Palmar, Guapota, Oiba, y demás, en la sede de San Gil capital de la provincia Guanentina con dieciocho (18) municipios entre los más cercanos, Mogotes, Curití, Pinchote y demás, acuden a los servicios del Consultorio Jurídico previa consulta del cumplimiento de los requisitos como lo es pertenecer al grupo de SISBEN hasta el C18 (Población Vulnerable). Se identificó que el Consultorio Juridíco de la Universidad Libre, cumple con su misión de impacto social, toda vez que se evidencian resultados en este estudio, con respuestas de alto impacto, llendo desde la atención primaria, pasando por el desarrollo de sus casos, hasta la solución o terminación de los mismos, estos ususarios se sienten a gusto y reconocen el servicio brindado de alta calidad.Universidad Libre Seccional Socorro -- Facultad de ciencias económicas, administrativas y contables -- Especialización en gerencia empresarialThe project "Measurement of Satisfaction and Quality in the Service of the Consultorio Jurídico of the Universidad Libre Seccional Socorro," from the perspective of its users, is an investigation that identified the viewpoints of the users of the Consultorio Jurídico of the Universidad Libre Seccional Socorro in its service locations, one in the municipality of Socorro and another in the municipality of San Gil - Santander. The research focused on users from the municipalities near the two service locations, Socorro, the capital of the Comunera province with fourteen (14) municipalities, including Confines, Simacota, Palmas de Socorro, Palmar, Guapota, Oiba, and others. In the San Gil location, the capital of the Guanentina province with eighteen (18) municipalities, among the closest being Mogotes, Curití, Pinchote, and others, individuals access the services of the Consultorio Jurídico after meeting the requirements, such as belonging to the SISBEN group up to C18 (Vulnerable Population). It was identified that the Legal Office of the Universidad Libre fulfills its mission of social impact, since results are evident in this study, with high-impact responses, filling everything from primary care, through the development of their cases, to the solution or termination thereof, these users feel comfortable and recognize the high quality service provided

KIR Genes and their Ligands Predict the Response to Anti-2 EGFR Monoclonal Antibodies in Solid Tumors

Killer-cell immunoglobulin-like receptors (KIRs) regulate the killing function of NK cells, which play an important role in the antibody-dependent cell-mediated cytotoxicity (ADCC) response exerted by therapeutic monoclonal antibodies (mAbs). However, it is unknown whether the extensive genetic variability of KIR genes and/or their HLA ligands might influence the response to these treatments. This study aimed to explore whether the variability in KIR/HLA genes may be associated to the variable response observed to mAbs-based anti-EGFR therapies. Thirty-nine patients treated with anti-EGFR mAbs (trastuzumab for advanced breast cancer, or cetuximab for advanced colorectal or advanced head and neck cancer), were included in the study. All the patients had progressed to mAbs therapy and were grouped into two categories taking into account time to treatment failure (TTF ≤6 months and TTF ≥10 months). KIR genotyping (16 genetic variability) was performed in genomic DNA from peripheral blood by PCR sequence-specific primer technique and HLA ligand typing was performed for HLA-B & -C loci by reverse PCR-SSO methodology. Subjects carrying the KIR/HLA ligand combinations KIR2DS1/HLAC2C2-C1C2 and KIR3DS1/HLABw4w4-w4w6 showed longer TTF than non-carriers counterparts (14,76 m vs 3,73 m, p<0.001, and 14,93 m vs 4,6 m, p=0.005 respectively). No other significant differences were observed. Two activating KIR/HLA ligand combinations predict better response of patients to anti-EGFR therapy. These findings increase the overall knowledge on the role of specific gene variants related with responsivenessto anti-EGFR treatment in solid tumours and highlight the importance of assessing gene polymorphisms related with cancer medications

NeuroPredict: study of the predictive value of ABCB1 genetic polymorphisms and associated clinical factors in chronic chemotherapy-induced peripheral neuropathy (CIPN)

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common entity (30%–40%) and can significantly limit the quality of life of patients, especially those that persist for more than 6 months after treatment (chronic neuropathy). Studies have shown a possible association between the presence of genetic polymorphisms in ABCB1 and the development of acute CIPN, although this relationship with chronic CIPN remains unexplored. This is an analytical observational case-control study defined by the presence (cases) or absence (controls) of CIPN at 6 months after the end of the neurotoxic drug. Our aim is to demonstrate whether these ABCB1 polymorphisms also influence the chronification of this toxicity, as well as the clinical factors that can help us to predict it.Methods: The study included 152 patients treated with tri-weekly oxaliplatin (O) or weekly paclitaxel (P); 86 cases and 66 controls. Clinical and analytical parameters were analysed including the study of ABCB1 genetic polymorphisms in a blood sample.Results: ABCB1 genetic polymorphisms C1236T (rs1128503) and C3435T (rs1045642) are associated with the development of chronic CIPN in patients treated with P. No differences were found in patients treated with O. Other predictive factors to be considered in the development of this toxicity are age &gt;60 years, BMI ≥30, toxic habits and cardiovascular risk factors.Conclusion: CIPN is a common and understudied toxicity, despite being a limiting factor in the quality of life of many patients. As described in acute CIPN, our study demonstrates the relationship between chronic neuropathy and being a carrier of specific polymorphisms (C1236T and C3435T) of the ABCB1 gene in patients treated with P. In addition, there are modifiable factors (obesity, smoking, or alcohol) that may influence its development. Further prospective studies are needed to investigate genetic and clinical modifiable factors predisposing to CIPPN to develop prevention and treatment strategies