Unfolding designable structures

Among an infinite number of possible folds, nature has chosen only about 1000 distinct folds to form protein structures. Theoretical studies suggest that selected folds are intrinsically more designable than others; these selected folds are unusually stable, a property called the designability principle. In this paper we use the 2D hydrophobic-polar lattice model to classify structures according to their designability, and Langevin dynamics to account for their time evolution. We demonstrate that, among all possible folds, the more designable ones are easier to unfold due to their large number of surface-core bonds.Comment: 10 pages, 4 figures, Proceeding of the 3rd International Conference NEXT-SigmaPh

Microscopic mechanism for cold denaturation

We elucidate the mechanism of cold denaturation through constant-pressure simulations for a model of hydrophobic molecules in an explicit solvent. We find that the temperature dependence of the hydrophobic effect is the driving force/induces/facilitates cold denaturation. The physical mechanism underlying this phenomenon is identified as the destabilization of hydrophobic contact in favor of solvent separated configurations, the same mechanism seen in pressure induced denaturation. A phenomenological explanation proposed for the mechanism is suggested as being responsible for cold denaturation in real proteins

A presença das multinacionais brasileiras em Portugal no contexto ibérico, europeu e global

This paper is about two cases of Brazilian companies, WEG S/A and Lusosider S/A, with presence in Portugal. Through empirical and bibliographical research, we show the main determinants that made such companies to choose Portugal to invest, as well as how they are developing in that country, having a basis the current process of globalization and the increase of the foreign direct investment by the emergent countries. We concluded that WEG S/A as Lusosider S/A is getting success in management of its internationalization in Portugal within European Union context.Este artigo trata de dois casos de companhias brasileiras, WEG S/A e Lusosider S/A, com presença em Portugal. Através de pesquisa empírica e bibliográfica, mostra-se os principais determinantes que fizeram estas companhias escolherem Portugal para investir,bem como a performance destas empresas neste país, tendo como base o atual processo de globalização e o aumento do investimentos direto estrangeiro pelos países emergentes.Concluímos que tanto a WEG S/A quanto a Lusosider S/A estão a obter sucesso no gerenciamento da sua internacionalização em Portugal no contexto ibérico, europeu e global