Massimo A. Bonfantini, Rossella Fabbrichesi, Salvatore Zingale (a cura di), Su Peirce. Interpretazioni, ricerche, prospettive

Charles Sanders Peirce (1839-1914) is known today as the first American philosopher, and as the ‘founder of pragmatism.’ Indeed, Peirce was both and much more. In a partial list of roles he played during his life, Peirce graduated as a chemist, published as an astronomer, worked in geodesy, wrote as a philosopher, and defined himself as a logician. While he gained only a partial, late recognition in his time, today the broadness of his interests is reflected by the diversity of the people tha..

The Philosophical Psychology of Charles S. Peirce

This work is about the philosophy of Charles Sanders Peirce (1839-1914) and nineteenth century psychology. More precisely, it is about the interactions between Peirce’s scientific practice as an experimental psychologist and the development of his philosophical reflection, especially his epistemology. The main thesis of this work is that Peirce’s theory of perception is inferential, and that this has far-reaching consequences on his account of the self, on his reflection on the method of science and on what counts as a scientific fact. This latter point also connects his theory of inquiry with his distinctive metaphysics of continuity. I defend my thesis as follows. In the first chapter, I explore the early development of an inferential account of perception in Peirce and its connections with his logic of science and his theory of inquiry more broadly. To do so, I examine Peirce’s 1865 Harvard Lectures in light of the inferential philosophy of science of William Whewell and the theory of perception as unconscious inferences presented by Wilhelm Wundt in 1862-3. In the second chapter, I bring Peirce’s inferentialism to bear on some of his better-known works: the 1868 “cognition” papers and the Illustrations of the Logic of Science of 1877-8. The third chapter further expands the context of Peirce’s inferential theory of perception by looking at German psychology and finding a new perspective from which to assess Kant’s influence on Peirce’s thought. Chapter 4 looks at Peirce’s use of experimental psychology in photometry and measurement techniques developed for astronomy in psychology. Chapter 5 engages with Peirce’s “boundary work” on science by comparing his engagement with psychical research with James’ and looking at Peirce’s metaphysics in relation to evolutionary psychology. Finally, Chapter 6 assesses Peirce’s “mature” theory of perception in light of psychical research and his metaphysics of continuity

STATIC AND DYNAMIC ANALYSES FOR PROTECTING THE JAVA SOFTWARE EXECUTION ENVIRONMENT

In my thesis, I present three projects on which I have worked during my Ph.D. studies. All of them focus on software protection in the Java environment with static and dynamic techniques for control-flow and data-dependency analysis. More specifically, the first two works are dedicated to the problem of deserialization of untrusted data in Java. In the first, I present a defense system that was designed for protecting the Java Virtual Machine, along with the results that were obtained. In the second, I present a recent research project that aims at automatic generation of deserialization attacks, to help identifying them and increasing protection. The last discussed work concerns another branch of software protection: the authentication on short-distance channels (or the lack thereof) in Android APKs. In said work, I present a tool that was built for automatically identifying the presence of high-level authentication in Android apps. I thoroughly discuss experiments, limitations and future work for all three projects, concluding with general principles that bring these works together, and can be applied when facing related security issues in high-level software protection

Prevention of neurological injuries during mandibular third molar surgery: technical notes

Surgery to the mandibular third molar is common, and injuries to the inferior alveolar nerve and the lingual nerve are well-recognized complications of this procedure. The aim of these technical notes is to describe operative measures for reducing neurological complications during mandibular third molar surgery. The following procedure should be used to prevent damage to the inferior alveolar nerve: a well-designed mucoperiosteal flap, to obtain appropriate access to the surgical area; a conservative ostectomy on the distal and distal-lingual side; tooth sectioning, to facilitate its removal by decreasing the retention zones; tooth dislocation in the path of withdrawal imposed by the curvature of the root apex; and careful socket debridement, when the roots of the extracted tooth are in intimate contact with the mandibular canal. To prevent injury to the lingual nerve, it is important (I) to assess the integrity of the mandibular inner cortex and exclude the presence of fenestration, which could cause the dislocation of the tooth or its fragment into the sublingual or submandibular space; (II) to avoid inappropriate or excessive dislocation proceedings, in order to prevent lingual cortex fracture; (III) to perform horizontal mesial-distal crown sectioning of the lingually inclined tooth; (IV) to protect the lingual flap with a retractor showing the cortical ridge; and (V) to pass the suture not too apically and from the inner side in a buccal-lingual direction in the retromolar are

Performance of mesenchymal cell-scaffold constructs in human oral reconstructive surgery: a systematic review

Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few clinical trials involving humans. Aim: This study reviewed all of the English language literature published between January 1990 and December 2015 to assess the histological performance of different mesenchymal cell-scaffold constructs used for bone regeneration in human oral reconstructive procedures. Methods: An electronic search of the MEDLINE and Cochrane Central Register of Controlled Trials databases complemented by manual searching was conducted to identify studies involving histological evaluation of mesenchymal cell-scaffold constructs in human oral surgical procedures. The methodological quality of randomized controlled clinical trials and controlled clinical trials was assessed using the Cochrane Collaboration tool for assessing the risk of bias. Heterogeneity was assessed using Review Manager software. Considering the heterogeneity, the data collected were reported by descriptive methods and a meta-analysis was applied only to the articles that reported the same outcome measures. The articles were classified and described based on the material scaffolds used. Results: The search identified 1030 titles and 287 abstracts. Full-text analysis was performed for 32 articles, revealing 14 studies that fulfilled the inclusion criteria. Three randomized controlled clinical trials were identified as potentially eligible for inclusion in a meta-analysis. The studies were grouped according to the scaffold materials used: bone allograft (three studies), polyglycolic-polylactic scaffold (four studies), collagen sponge (two studies), and bovine bone matrix (five studies). The stem cells used in these studies had been sourced from the iliac crest, periosteum, dental pulp and intraoral sites. Conclusions: The very small amount of available data makes it impossible to draw any firm conclusions regarding the increase in bone formation in human oral reconstructive procedures when using graft materials engineered with autogenous stem cells

Comparative histological and histomorphometric results of six biomaterials used in two-stage maxillary sinus augmentation model after 6-month healing

To evaluate the performances of six different bone substitute materials used as graft in maxillary sinus augmentation by means of histological and histomorphometric analysis of bone biopsies retrieved from human subjects after a 6-month healing period. Materials and Methods. Six consecutive patients (3 males, 3 females, aged 50-72 years), healthy, nonsmokers, and with good oral hygiene, presenting edentulous posterior maxilla with a residual bone crest measuring ≤ 4 mm in vertical height and 3 to 5 mm in horizontal thickness at radiographic examination, were selected to receive sinus augmentation and delayed implant placement. Under randomized conditions, sinus augmentation procedures were carried out using mineralized solvent-dehydrated bone allograft (MCBA), freeze-dried mineralized bone allograft (FDBA), anorganic bovine bone (ABB), equine-derived bone (EB), synthetic micro-macroporous biphasic calcium-phosphate block consisting of 70% beta-tricalcium phosphate and 30% hydroxyapatite (HA-β-TCP 30/70), or bioapatite-collagen (BC). After 6 months, bone core biopsies were retrieved and 13 implants were placed. Bone samples were processed for histological and histomorphometric analysis. CT scans were taken before and after surgery. After 4 months of healing, patients were restored with a provisional fixed acrylic resin prosthesis, as well as after further 2-4 months with a definitive cemented zirconia or porcelain-fused-to-metal crowns. Results. There were no postoperative complications or implant failures. The histological examination showed that all biomaterials were in close contact with newly formed bone, surrounding the graft granules with a bridge-like network. No signs of acute inflammation were observed. The histomorphometry revealed 20.1% newly formed bone for MCBA, 32.1% for FDBA, 16.1% for ABB, 22.8% for EB, 20.3% for HA-β-TCP 30/70, and 21.4% for BC. Conclusions. Within the limitations of the present investigation, all the six tested biomaterials showed good biocompatibility and osteoconductive properties when used in sinus augmentation procedures, although the FDBA seemed to have a better histomorphometric result in terms of newly formed bone and residual graft material. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03496688

Histomorphometric evaluation of bone regeneration induced by biodegradable scaffolds as carriers for dental pulp stem cells in a rat model of calvarial "critical size" defect

Objective: The aim of this study was to test specific stem cells that could enhance bone formation in combination with specific scaffolds. Methods: Dental Pulp Stem Cells (DPSCs) were seeded with Granular Deproteinized Bovine Bone (GDPB) or Beta-Tricalcium Phosphate (ß-TCP) in a rat model of calvarial "critical size" defect. DPSCs were isolated from permanent human teeth, obtained and characterized using specific stem cells markers (Nanog and Oct-4) by real time-PCR and immunofluorescence. Cells were differentiated for 10-15 days towards the osteoblastic phenotype with 100μM L-ascorbic acid, added every day in culture medium and 20 vol. percentage of FBS in α-MEM medium. Osteogenic commitment was evaluated with real time-PCR by measuring the expression of specific markers (osteonectin and runx2). When a sufficient cell number was obtained, DPSCs were trypsinized, washed in culture medium and seeded onto the GDPB and ß-TCP scaffold sat a density of 0.5-1×106 cells/scaffold. Two bilateral critical-size circular defects (5 mm diameter; 1 mm thickness) were created from the parietal bone of the 8 athymic T-cell deficient nude rats. One cranial defect for each rat was filled with the scaffold alone and the other defect with the scaffold seeded with stem cells. After 12 weeks post-surgery animals were euthanized and histomorphometric analysis was performed. Differences between groups were analyzed by one-way analysis of variance (ANOVA) followed by Fisher's Protected Least Significant Difference (PLSD) post-hoc test. A p-value <0.05 was considered statistically significant. Results: GDPB group presented higher percentage of lamellar bone than that of GDPB/DPSC, ß-TCP alone had lower levels as compared to ß-TCP/DPSC. The addition of stem cells significantly increased woven bone formation in both scaffold-based implants, although still higher in GDPB based implants. Conclusion: Our findings indicate that GDPB and ß-TCP used as scaffold to induce bone regeneration may benefit from adding DPSC to tissue-engineered constructs

Prevention and early diagnosis of oral carcinoma in construction workers in Italy: a pilot project

Objectives: A research project on occupational exposure in relation to oral carcinoma was periodic compulsory check-ups, oral examinations were performed to detect pathologies and the prevalence of potentially neoplastic oral conditions and a selfassessment questionnaire was administered to all of the subjects. The questionnaire was structured to collect information regarding demographic and clinical characteristics, risk habits (tobacco and alcohol consumption) and oral health habits, and to allow an assessment of knowledge about oral cancer, related risk factors and early signs. Results: The study cohort included people with different ethnicities, and there were significant differences in clinical characteristics between Italians and other Europeans. The subjects showed a good knowledge about oral cancer and related risk factors (with correct answers provided to >50% of the questions) but insufficient knowledge about the early signs of oral carcinoma (correct-answer rates of 16–42%). There were high rates of habits that are potentially harmful to oral health, such as smoking (43.8%) and alcohol consumption (57%). The daily habit of brushing teeth was present in 92.6% of the subjects, but they had a low propensity to undergo regular dental examinations. The percentage of subjects with pathologies of the oral cavity was 18.6%. Conclusions: Despite the smallness of the sample, this pilot project could facilitate the acquisition of valid and cost-effective data for the primary prevention of oral cancer through information and educational campaigns on the related risk factors

Surgical management of extrafollicular variant of adenomatoid odontogenic tumor in the maxillary posterior region

Background. Adenomatoid odontogenic tumor (AOT) is a relatively uncommon benign neoplasm of odontogenic epithelial origin, accounting for less than 5% of odontogenic tumors. Case Report. The reported case describes morphological characteristics, clinical course, radiographic and histopathological features, and surgical therapy of an extrafollicular variant of AOT in the maxillary posterior region. An asymptomatic swelling on the left side in the posterior region of the maxilla, gradually increased since approximately 12 months, developed in a 16-year-old Caucasian female patient. Radiographic images revealed a well-defined, unilocular radiolucency, with some small foci of radiopacity inside, and root resorption of the first and second molars. On the base of the histological examination of the specimen retrieved by incisional biopsy, the diagnosis of AOT was made, and the conservative surgical enucleation of the lesion was performed. Discussion. The present case was reported in agreement with an extensive review, in which it was recommended to discontinue reporting classic follicular cases because their clinicopathological profile was well-known, but to continue reporting well-documented cases of the extrafollicular variant, with indication of the exact position. Conclusion. The present case was reported in order to expand the knowledge about the clinical behavior and surgical treatment of the extrafollicular variant of AOT