30 research outputs found
The climatic and genetic heritage of Italian goat breeds with genomic SNP data
GENOTYPE DATABASE ITALIAN GOAT CONSORTIU
A genome scan for milk production traits in dairy goats reveals two new mutations in <i>Dgat1</i> reducing milk fat content
The quantity of milk and milk fat and proteins are particularly important traits in dairy livestock.
However, little is known about the regions of the genome that influence these traits in goats. We
conducted a genome wide association study in French goats and identified 109 regions associated
with dairy traits. For a major region on chromosome 14 closely associated with fat content, the
Diacylglycerol O-Acyltransferase 1 (DGAT1) gene turned out to be a functional and positional candidate
gene. The caprine reference sequence of this gene was completed and 29 polymorphisms were found in
the gene sequence, including two novel exonic mutations: R251L and R396W, leading to substitutions
in the protein sequence. The R251L mutation was found in the Saanen breed at a frequency of 3.5% and
the R396W mutation both in the Saanen and Alpine breeds at a frequencies of 13% and 7% respectively.
The R396W mutation explained 46% of the genetic variance of the trait, and the R251L mutation 6%.
Both mutations were associated with a notable decrease in milk fat content. Their causality was then
demonstrated by a functional test. These results provide new knowledge on the genetic basis of milk
synthesis and will help improve the management of the French dairy goat breeding program
A genome-wide association study for calving interval in holstein dairy cows using weighted single-step genomic BLUP approach
peer reviewe
Genome-wide association for milk production and lactation curve parameters in Holstein dairy cows
peer reviewe
Genetic parameters for milk urea and its relationship with milk yield and compositions in Holstein dairy cows
peer reviewe
The Accidental Archaeologist: The Unfortunate Case of Antonio Filippello and the Coin Hoard of Castiglione (Catania, Sicily, 1818)
Particelle del virus HIV-1 negli spermatozoi di pazienti affetti da AIDS e loro trasferimento nell'oocita
Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib.
To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher in patients with 140mg starting dose (50.0% vs 19.6%, p=0.001). Grade 3-4 pleuro-pericardial effusions occurred in 10 patients (8.0%). Dose reductions were more common in patients with 140mg (88.4% vs 26.7%, p<0.001). Of 122 evaluable patients, 72 (59.1%) had cytogenetic response [12 (9.8%) partial, 60 (49.3%) complete]. Overall, 38/60 patients in complete CyR also achieved a molecular response. Cumulative OS at 24 and 48 months were 93.1% (95% CI 88.4-97.8) and 84.2% (95% CI 74.6-93.7). Dasatinib, at the recommended dose of 100mg/day, is effective and safe also in unselected elderly subjects