Critical Issues for Psychiatric Medication Shared Decision Making With Youth and Families

This is the publisher's version, also found here: http://doi.org/10.1606/1044-3894.4135The primary aims of this article are to describe the current context for youth shared decision making (SDM) within the U.S. children’s mental health system and to identify important considerations for the development of this approach as a research and service domain. The notion is substantiated in the literature that participation in treatment decisions can prepare youth for making their own decisions as adults, can be therapeutic, and can have positive effects on their self-confidence and self-esteem. Still, the complex youth–family–provider dynamic raises important issues that need to be addressed before SDM can be successfully implemented

FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development

Developmental signalling pathways are implicated in the formation and maintenance of the adrenal gland, but their roles are currently not well defined. In recent years it has emerged that Sonic hedgehog (Shh) and Wnt/β catenin signalling are crucial for the growth and development of the adrenal cortex. Here we demonstrate that Fibroblast growth factor receptor (Fgfr) 2 isoforms IIIb and IIIc are expressed mainly in the adrenal subcapsule during embryogenesis and that specific deletion of the Fgfr2 IIIb isoform impairs adrenal development, causing reduced adrenal growth and impaired expression of SF1 and steroidogenic enzymes. The hypoplastic adrenals also have thicker, disorganised capsules which retain Gli1 expression but no longer express Dlk1. Fgfr2 ligands were detected in both the capsule and the cortex, suggesting the importance of signalling between the capsule and the cortex in adrenal development

Genomic aberrations in borderline ovarian tumors

<p>Abstract</p> <p>Background</p> <p>According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH.</p> <p>Methods</p> <p>We report a series of borderline ovarian tumors (n = 23) analyzed by G-banding and karyotyping as well as high resolution CGH; in addition, the tumors were analyzed for microsatellite stability status and by FISH for possible 6q deletion.</p> <p>Results</p> <p>All informative tumors were microsatellite stable and none had a deletion in 6q27. All cases with an abnormal karyotype had simple chromosomal aberrations with +7 and +12 as the most common. In three tumors with single structural rearrangements, a common breakpoint in 3q13 was detected. The major copy number changes detected in the borderline tumors were gains from chromosome arms 2q, 6q, 8q, 9p, and 13q and losses from 1p, 12q, 14q, 15q, 16p, 17p, 17q, 19p, 19q, and 22q. The series included five pairs of bilateral tumors and, in two of these pairs, informative data were obtained as to their clonal relationship. In both pairs, similarities were found between the tumors from the right and left side, strongly indicating that bilaterality had occurred via a metastatic process. The bilateral tumors as a group showed more aberrations than did the unilateral ones, consistent with the view that bilaterality is a sign of more advanced disease.</p> <p>Conclusion</p> <p>Because some of the imbalances found in borderline ovarian tumors seem to be similar to imbalances already known from the more extensively studied overt ovarian carcinomas, we speculate that the subset of borderline tumors with detectable imbalances or karyotypic aberrations may contain a smaller subset of tumors with a tendency to develop a more malignant phenotype. The group of borderline tumors with no imbalances would, in this line of thinking, have less or no propensity for clonal evolution and development to full-blown carcinomas.</p

Rad54 drives ATP–hydrolysis dependent DNA sequence alignment during homologous recombination

Raw data from single molecule experiments

Canada's ocean and maritime security a strategic forecast : A strategic forecast

Canada is a major maritime country with a wide range of interests and concerns in three oceans. The sea is a vital factor in the development of its economy. Canadian policy for the protection of its maritime vital interests has been implemented through a blend of law, force and diplomacy. The strategy has been one of surveillance, monitoring and enforcement, or in military terms, naval presence and sea control. Over the next two decades, the scale and complexity of increasing oceans use in the northwest Atlantic, the northeast Pacific, and in Canadian Arctic waters will have profound implications for Canadian security, broadly defined. Trends in the patterns of marine transportation and ocean use, especially the management of ocean resources, and the broad requirements to preserve the security of Canada's other maritime vital interests at home and overseas will increasingly have foreign policy implications. In this regard, oceans policy, like security policy, will need to become more closely integrated into the foreign policy process. Similarly, the fishery and living resources, offshore energy, marine transportation and navigation, the marine environment, maritime boundary delimitations, marine science and technology and recreation and community development will call for closer coordination between federal and provincial governments. Maritime security will require the meshing of policy and instruments of surveillance, monitoring and enforcement to meet the challenges of law enforcement and marine emergencies, and to protect maritime sovereignty. Multilateral, regional cooperation in the protection and management of Canada's three oceans is an imperative, dictated by interdependence for reasons of politics and costs. These factors call for a comprehensive national oceans policy, integrated marine strategies, and a naval and regulatory force posture capable of ensuring the harmonious and sustainable use of Canada's contiguous seas.