RESPONSE OF A WINTERING MOOSE POPULATION TO ACCESS MANAGEMENT AND NO HUNTING – A MANITOBA EXPERIMENT

We report on an experiment undertaken in eastern Manitoba beginning in 1996, in which a moose population wintering in 62 km2 (24.2 mi2) was protected from hunting until September 2003. At the time of closure, it is speculated that about 37 (0.6/km2 (1.5/mi2)) moose wintered in the area based on aerial surveys and considering visibility bias. The closure was supported by the Eastern Region Committee for Moose Management, which is comprised of Manitoba Conservation staff, First Nation representatives from local communities, local hunting organizations, and other interest groups such as Tembec Manitoba Incorporated and the Manitoba Model Forest. Road access to the area was curtailed by using locked gates, millstones, and V-plowing a portion of the road in 2002. The area was surveyed from a helicopter on March 4, 2003, and 107 moose were counted in the closed area and again, based on visibility bias, it is speculated that about 142 moose (2.3/km2 (5.8/mi2)) were present. This experiment clearly demonstrates that moose will respond positively to access management and no hunting, and that V-plowing roadbeds is a useful technique for controlling access. The cost associated with such plowing varies from about $500-$1,500/km depending on material contained in the roadbed

Opening Session: Welcome and Award Presentation

Welcoming remarks from UM Chancellor R. Gerald Turner and conference organizers Presentation of Eudora Welty Awards in Creative Writing by William Ferris and Frances Patterson Faulkner Write-Alike Contest: Background and Announcement of Winners by Doug Crichton, Willie Morris, George Plimpton, Dean Faulkner Wells, and Lawrence Well

Diagnostic Accuracy and economic value of a Tiered Assessment for Fetal Alcohol Spectrum Disorder (DATAforFASD): Protocol

Introduction Australian practices for diagnosing fetal alcohol spectrum disorder (FASD) are lengthy and require specialist expertise. Specialist teams are based in urban locations; they are expensive and have prolonged waitlists. Innovative, flexible solutions are needed to ensure First Nations children living in rural/remote communities have culturally appropriate and equitable access to timely diagnosis and support. This study compares the accuracy of rapid assessments (index tests) that can be administered by a range of primary healthcare practitioners to specialist standardised FASD assessments (reference tests). The cost-efficiency of index tests will be compared with reference tests.Methods and analysis At least 200 children aged 6–16 years at-risk of FASD will be recruited across at least seven study sites. Following standards for reporting diagnostic accuracy study (STARD) guidelines, all children will complete index and reference tests. Diagnostic accuracy statistics (including receiver operating curves, sensitivity, specificity, positive and negative predictive values and likelihood ratios) will identify whether rapid assessments can accurately identify: (1) the presence of an FASD diagnosis and (2) impairment in each neurodevelopmental domain, compared to comprehensive assessments. Direct and indirect healthcare costs for index tests compared to reference tests will be collected in primary healthcare and specialist settings.Ethics and dissemination of results Children’s Health Queensland Hospital and Health Service Human Research Ethics Committee (HREC/20/QCHQ/63173); Griffith University Human Research Ethics Committee (2020/743). Results will assist in validating the use of index tests as part of a tiered neurodevelopmental assessment process that was co-designed with First Nations community and primary healthcare practitioners. Outcomes will be summarised and provided to participating practitioners and sites, and disseminated to community health services and consumers. Findings will be presented at national and international conferences and published in peer-reviewed journals.Trial registration number ACTRN12622000498796

100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.

BACKGROUND: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care implementation in the U.K. National Health Service. Other parts of this project focus on patients with cancer and infection. METHODS: We conducted a pilot study involving 4660 participants from 2183 families, among whom 161 disorders covering a broad spectrum of rare diseases were present. We collected data on clinical features with the use of Human Phenotype Ontology terms, undertook genome sequencing, applied automated variant prioritization on the basis of applied virtual gene panels and phenotypes, and identified novel pathogenic variants through research analysis. RESULTS: Diagnostic yields varied among family structures and were highest in family trios (both parents and a proband) and families with larger pedigrees. Diagnostic yields were much higher for disorders likely to have a monogenic cause (35%) than for disorders likely to have a complex cause (11%). Diagnostic yields for intellectual disability, hearing disorders, and vision disorders ranged from 40 to 55%. We made genetic diagnoses in 25% of the probands. A total of 14% of the diagnoses were made by means of the combination of research and automated approaches, which was critical for cases in which we found etiologic noncoding, structural, and mitochondrial genome variants and coding variants poorly covered by exome sequencing. Cohortwide burden testing across 57,000 genomes enabled the discovery of three new disease genes and 19 new associations. Of the genetic diagnoses that we made, 25% had immediate ramifications for clinical decision making for the patients or their relatives. CONCLUSIONS: Our pilot study of genome sequencing in a national health care system showed an increase in diagnostic yield across a range of rare diseases. (Funded by the National Institute for Health Research and others.)